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Integument Definitions
VM 608 Midterm
66
Veterinary Medicine
Professional
04/14/2012

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Term
primary lesion
Definition
direct result of underlying disease process
most important diagnostically
Term
secondary lesions
Definition
evolve from primary lesions (self trauma, etc)
less important diagnostically
Term
Maccule
Definition
circumscribed area of discoloration up to 1 cm in diameter
flat not raised
Term
Patch
Definition
macule over 1 cm in diameter
flat not raised
Term
Papule
Definition
small <1cm solid elevation of the skin
Term
Plaque
Definition
a larger, flat topped elevation formed by the extension of coalition of papules
Term
Nodules
Definition
a circumscribed, solid elevation >1cm that extends into the deep layers
Term
Tumor
Definition
a large mass (neoplasia implied_ that may involve any structure of the skin or subcutis
Term
Cyst
Definition
an epithelial lined cavity containing fluid or solid material
Term
Vesicle
Definition
a well circumscribed <1cm elevation of the epidermis filled with clear fluid
Term
Bulla
Definition
a vesicle grater than 1 cm in diameter
Term
Pustule
Definition
a small circumscribed, pus (suppurative inflammation) filled elevation of the epidermis
Term
Abscess
Definition
a well demarcated fluctuant lesion resulting from dermal/subcutaneous pus
Term
Scale
Definition
accumulation of loose fragments of cornified skin
Term
Crust
Definition
an accumulation of dried exudate, blood/serum, scale or medication adherent to the skin surface
Term
Collarette
Definition
crusts that spread outward in a circular fashion
Term
Comedo
Definition
a dilated hair follicle filled with cornified cells and sebaceous material
Term
Alopecia
Definition
loss of hair
Term
Hypotrichosis/Atrichia
Definition
decreased amount of or absence of hair
Term
Effluvium
Definition
excessive shedding
Term
Hypertrichosis (hirsutism)
Definition
a more than normal amount of hair
Term
Red (erythema)
Definition
due to inflammation or vasodilation
Term
Black
Definition
hypermelanosis
Term
Lichenification
Definition
thickening and hardening of the skin with exaggeration of superficial markings
Term
Red-purple-brown-black
Definition
hemorrhage
purpura, petechia, echhymosis
Term
Yellow
Definition
icterus
jaundice
Term
Blue to purple
Definition
cyanosis
Term
Erosion
Definition
shallow epidermal defect
doesn't penetrate the basement membrane
Term
Ulcer
Definition
break in the epidermis with exposure of the dermis
Term
Scar
Definition
an area of fibrous tissue that has replaced the damaged dermis and/or subcutis
Term
Perivascular/Interstitial Dermatitis
Definition
inflammatory reaction centered on the superficial and/or deep dermal vessels
edema and perivascular accumulation of inflammatory cells
Term
Spongiotic Perivascular Dermatitis
Definition
inflammatory reaction centered on the superficial and/or deep dermal vessels along with edema between keratinocytes
Term
Hyperplastic Perivascular Dermatitis
Definition
inflammatory reaction centered on the superficial and/or deep dermal vessels along with prominent epidermal hyperplasia
Term
Causes of Perivascular/Interstitial Dermatitis
Definition
hypersensivitiy reactions
Term
Causes of Spongiotic Perivascular Dermatitis
Definition
hypersensitivities, contact dermatitis, ectoparasitism, dermatophytosis, malasseziasis
Term
Causes of Causes of Hyperplastic Perivascular Dermatitis
Definition
chronic hypersensitivity, altered keratinization, lick dermatitis
Term
Interface Dermatitis
Definition
obscuring of the dermoepidermal junction
Term
Causes of Interface Dermatitis
Definition
immune-mediated or autoimmune, drug reactions, viral infections
Term
Inferface Lichemoid Dermatitis
Definition
obscuring of the dermoepidermal junction with infiltration of inflammatory cells in the dermis
Term
Vascultitis
Definition
inflammation and damage to the blood vessel walls
Term
Causes of Vasculitis
Definition
infections, immune-mediated diseases
Term
Nodular Dermatitis
Definition
discrete clusters of inflammatory cells within the dermis
Term
Diffuse Dermatitis
Definition
dense diffuse inflammatory cell infiltrate with effacement of normal dermal architecture
Term
Intraepidermal Vesicles or Pustules
Definition
acantholysis, coalescing ballooning degeneration, intense intra/intecellular edema
Term
Subepidermal Vesicles/Pustules
Definition
dermoepidermal separation
subepidermal edema and/or cellular infiltration
Term
Perifolliculitis
Definition
inflammatory cells surrounding hair follicle
Term
Folliculitis
Definition
inflammatory cells within the wall and/or lumen of the hair follicle
Term
Furunculosis
Definition
effacement/rupture of hair follicle due to intense inflammation
Term
Causes of Perifolliculitis, Folliculitis, Furunculosis
Definition
bacteria, mites, dermatophytes
Term
Panniculitis
Definition
Inflammation of the panniculus or hypodermis
Term
Causes of Panniculitis
Definition
nutritional, injection, idiopathic, pancreatic induced in cats, blastomycosis
often an extension from nodular or diffuse dermatitis
Term
Atrophic Dermatitis
Definition
Adnexal structure atrophy
Term
Causes of Atrophic Dermatitis
Definition
endocrine disorders
Term
Congenital Hypotrichosis
Definition
absence of hair follicles and/or abnormal follicular development
present in all domestic species
Term
Causes of Hypotrichosis in Cattle
Definition
BVD, pituitary hypoplasia, teratogens
common in German Holstein cows (also get adontia)
Term
Ichthyosis
Definition
plates of compact keratin due to a congenital keratinization disorder
Term
Cyclical Flank Alopecia
Definition
Bilateral alopecia in shape of saddle on the dorsal lateral thorax with skin hyperpigmentation
Term
Causes of Cyclical Flank Alopecia
Definition
unknown
Term
Actinic Injury
Definition
sun injury
UV-A, UV-B, UV-C and visible light generate free radicals
free radicals cause cell damage and death
mutagenesis of P53 tumor suppressor gene and hyperplasia of keratinocytes
Term
Primary Phototoxicity
Definition
sunburn
direct endothelial damage and damage to keratinocytes
release of inflammatory mediators
Term
Photosensitization
Definition
photodynamic substances in skin are activated by UV-A or visible light
Term
Type I Photosensitization
Definition
exogenous origin of photodynamic agents
eating of toxins like St. John's Wort, Buckwheat, Bishop's weed, Spring Parsley
Term
Type II Photosensitization
Definition
aberrant heme pigment synthesis
Bovine Congential Porphorya
Term
Type III Photosensitization
Definition
failure to remove phylloerythrin from liver damage
Chronic Alfatoxicosis
Term
Type IV Photosensitization
Definition
idiopathic
Term
Acral Lick Dermatitis
Definition
common in large breed dogs like Lab retriever, Golden retriever, German Shepherd
psychogenic - animal is bored or stressed so it licks itself as a calming mechanism
focal areas of alopecia, erythema, erosion/ulceration
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