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Inman domain 1 topic E
Nutrition and supporting sciences
406
Other
Post-Graduate
06/13/2018

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Term
The brain uses what for energy
Definition
glucose exclusively; ketones during starvation
Term
Glycogen is stored in these 2 places.
Definition
Muscle and liver
Term
Gluconeogenesis
Definition
Conversion of non-CHO sources into glucose (from glycerol and amino acids)
Term
Coenzymes can include
Definition
vitamins
Term
Some vitamin coenzymes for oxidation include
Definition
pantothenic acid, thiamin, riboflavin, niacin (for energy production)
Term
Cofactors can include
Definition
minerals
Term
Coenzymes vs cofactors
Definition
coenzymes are vitamins, cofactors are minerals
Term
Endocrine glands secrete
Definition
hormones
Term
Hormones
Definition
Chemical messengers that trigger enzymes
Term
Thyroxine
Definition
A thyroid hormones that regulates metabolism and rate of oxidation. Influences physical/mental growth. Stimulates liver glycogenolysis and gluconeogenesis - raises blood sugar.
Term
Stimulates liver glycogenolysis and gluconeogenesis - raises blood sugar.
Definition
Thyroxine
Term
Influences physical/mental growth.
Definition
Thyroxine
Term
A thyroid hormones that regulates metabolism and rate of oxidation.
Definition
Thyroxine
Term
TEE
Definition
Total energy expenditure
Term
BEE
Definition
Basal energy expenditure
Term
Basal energy expenditure (BEE)
Definition
Min amount energy needed at rest in fasting to maintain being alive. Affected by extreme temperatures and caffeine, alcohol, nicotine
Term
Temperature can increase BEE by ___%
Definition
5-20%
Term
Caffeine, alcohol, nicotine can increase BEE by ___%
Definition
7-15%
Term
EEPA
Definition
Energy expended in physical activity
Term
AT
Definition
Activity thermogenesis
Term
TEF
Definition
Thermic effect of food
Term
DIT
Definition
Diet-induced thermogenesis
Term
The calorigenic effect of food (TEF, DIT)
Definition
10% of TEE. It's the energy needed to digest+absorb. Higher for CHO/pro than fat.
Term
What macro takes the least amount of energy to digest+absorb
Definition
fat
Term
BMR
Definition
Basal metabolic rate
Term
When do you measure BMR?
Definition
Morning, reclining, awake, relaxed, normal body temp, 12 h p last PO, several hours after strenuous activity if it was done
Term
What substance does BMR measure to measure BMR?
Definition
O2 consumed
Term
Women have a BMR ___% lower than men.
Definition
5-10%
Term
What age group has the highest BMR?
Definition
0-2 y/o
Term
Why do old people have lower BMRs?
Definition
Less activity, less lean body mass, more body fat
Term
What 4 factors affect BMR?
Definition
Sex, age, body composition/surface area, endocrine glands (thyroid)
Term
How do you measure activity of the thyroid gland?
Definition
PBI - Protein bound iodine
Term
2 thyroid gland hormones
Definition
thyroxine (T4) and triiodothyronine (T3)
Term
T4
Definition
thyroxine
Term
T3
Definition
triiodothyronine
Term
When PBI - Protein bound iodine is elevated, ___ is elevated.
Definition
BMR
Term
Wat does PBI - Protein bound iodine measure exactly?
Definition
The level of thyroxine produced, and since this hormone influences physical/mental growth, you are measuring energy metabolism.
Term
PBI - Protein bound iodine is NOT:
Definition
A nutritional assessment parameter
Term
BMR is higher during periods of:
Definition
Growth, like pregnancy, lactation, fever (7% increase for each increase in degree), some diseases, exercise
Term
RMR
Definition
Resting metabolic rate
Term
The RMR is ____% higher than the BMR.
Definition
10-20%
Term
Why is RMR higher than BMR?
Definition
Because measuring conditions aren't as strict
Term
Mifflin st. jeor predicts kcal needs within ___% of what indirect calorimetry would measure.
Definition
10%
Term
What is the most practical way of measuring energy balance?
Definition
Following changes in weight
Term
What is direct calorimetry?
Definition
Measures heat produced in a respiration chamber (limited usefulness)
Term
What is indirect calorimetry?
Definition
Measure O2 consumed and CO2 excreted using a portable machine.
Term
Indirect calorimetry is useful for which types of pts?
Definition
On the vent, athletes, burn victims
Term
The respiratory quotient RQ =
Definition
VCO2 expired divided by VO2 consumed
Term
RQ = 1 means
Definition
Pt only ate CHO
Term
RQ = 0.82 means
Definition
Pt only ate protein
Term
RQ = 0.7 means
Definition
Pt only ate fat
Term
RQ = 0.85 means
Definition
pt ate some combination of CHO/PRO/FAT
Term
FIO2
Definition
inspired O2
Term
FEO2
Definition
Expired O2
Term
FICO2
Definition
Inspired CO2
Term
FECO2
Definition
Expired CO2
Term
VI
Definition
Inspired minute ventilation
Term
Ve
Definition
expired minute ventilation (used in penn state)
Term
List the 3 monosaccharides
Definition
glucose, fructose, galactose
Term
List the 3 disaccharaides
Definition
Sucrose, lactose, and maltose
Term
Sucrose is made of
Definition
glucose and fructose
Term
Lactose is made of
Definition
Glucose and galactose
Term
Maltose is made of
Definition
Glucose and glucose
Term
Glucose and glucose makes
Definition
maltose
Term
Glucose and galactose makes
Definition
lactose
Term
Glucose and fructose makes
Definition
sucrose
Term
List the 5 polysaccharides
Definition
Starch, cellulose, pectin, glycogen dextrin
Term
Starch is made of
Definition
glucose chains
Term
Cellulose is resistant to
Definition
amylase. cellulose adds bulk
Term
Which starch is completely non-digestible?
Definition
Pectin
Term
Which starch has the best thickening quality?
Definition
Pectin
Term
Which starch is most commonly found in fruits?
Definition
Pectin
Term
Which starch comes from animals?
Definition
Glycogen
Term
Which starch is the intermediate pdt of starch breakdown?
Definition
Dextrin
Term
What is sorbitol?
Definition
Glucose alcohol, absorbed more slowly, converts to fructose, causes diarrhea
Term
What is the sweetest sugar?
Definition
Fructose
Term
What is the least sweet sugar?
Definition
Lactose
Term
List the sugars in order of sweetness.
Definition
1) fructose 2) invert sugars 3) sucrose 4) glucose 4) sorbitol 5) mannitol 6) galactose 7) maltose 8) lactose
Term
Invert sugars
Definition
a mixture of glucose and fructose obtained by the hydrolysis of sucrose
Term
Mannitol
Definition
a sugar alcohol
Term
What are 2 sugar alcohols
Definition
sorbitol and mannitol
Term
CHO allow most of protein to be used for
Definition
tissue synthesis
Term
CHO restriction leads to
Definition
ketosis
Term
CHO contains
Definition
C, H, O
Term
Pro contains
Definition
C, H, O, N, S
Term
The amino group of amino acids is
Definition
NH2 (base)
Term
The carboxyl group of amino acids is
Definition
COOH (Acid)
Term
List the 9 essential AA (TTPHLIMLV)
Definition
threonine, valine, tryptophan, isoleucine, leucine, lysine, phenylalanine, methionine, histidine
Term
Which 2 AA are conditionally essential during metabolic stress
Definition
arginine and glutamine
Term
Tryptophan is the precursor for what 2 substances?
Definition
Serotonin and niacin
Term
Serotonin and niacin need ____ to be created.
Definition
Tryptophan
Term
Phenylalanine is converted into
Definition
tyrosine
Term
Methionine is converted into
Definition
cysteine
Term
Definition of complete protein?
Definition
All essential AA are present in sufficient quantities and ratios to maintain body tissues and support growth
Term
HBV
Definition
High biological value
Term
If you need to give someone a low protein diet, what do you need to make sure of?
Definition
That the protein is of HBV.
Term
Incomplete protein
Definition
Deficient of 1 or more essential AA
Term
Simple protein
Definition
amino acids
Term
Conjugated protein
Definition
simple (AA) + a non-protein substance
ex: lipoprotein (fat+pro for transport)
Term
Derived protein
Definition
Fragments from simple and conjugated proteins (peptides)
Term
Protein sources
Definition
Animal muscle, eggs, milk, cheese, yogurt, legumes
Term
Protein fx
Definition
tissue synthesis, maintains growth, regulates body processes
Term
Which macro is an inefficient energy source? why?
Definition
Protein, bc nitrogen has to be removed first
Term
___% of any given amount of ingested protein can be converted to CHO for energy.
Definition
58%.
Term
Why can only 58% of any given amount of ingested protein be converted to CHO for energy?
Definition
Because the remaining % is the nitrogen on protein that has to be removed. There's no nitrogen in CHO
Term
How much protein is need on avg? /kg and % kcals?
Definition
0.8g/kg, 10-15% kcals
Term
Soybeans are low in what AA?
Definition
Methionine
Term
Which plant protein is equivalent in quality to animal protein?
Definition
SOY BABY
Term
Legumes are low in what AA?
Definition
methionine, cysteine, and tryptophan
Term
Gelatin is low in which AA?
Definition
Methionine, lysine
Term
Gelatin has 0 of which AA?
Definition
Tryptophan
Term
Fat is made of
Definition
C, H, O
Term
Simple TG are made of
Definition
3 FAs + 1 glycerol
Term
Most food fat is what type of fat?
Definition
TG
Term
Phospholipid is an example of what kind of fat?
Definition
Compound fat
Term
Most phospholipids are
Definition
lecithins (emulsifier) which contain choline (a lipotropic factor)
Term
Lipotropic factor
Definition
substances that have the ability to remove and prevent fatty deposits, esp in liver. Example: choline
Term
Choline is a
Definition
Lipotropic factor - substance that has the ability to remove and prevent fatty deposits.
Term
What helps prevent fatty deposits in the liver?
Definition
Lipotropic agents like choline
Term
What is LCAT?
Definition
an enzyme called lecithin-cholesterol acyltransferase
Term
Derived fats
Definition
Parts of fats derived from the hydrolysis or enzymatic breakdown of fats - FAs, glycerols, steroids
Term
FAs, glycerols, steroids are
Definition
Derived fats
Term
Saturated fats
Definition
All available bond of the carbon chain are filled with hydrogen; its solid and hard at room temperature
Term
Unsaturated fats
Definition
One or more double bonds
Term
Fat molecule with 1 double bond
Definition
monounsaturated fat
Term
Fat molecule with 2 or more double bonds
Definition
polyunsaturated fats
Term
Most polyunsaturated fat?
Definition
Safflower
Term
Most unsaturated fat?
Definition
Canola
Term
Essential FAs
Definition
Linoleic (omega 6), alpha linolenic (omega 3)
Term
Essential FAs - what happens when you don't eat em
Definition
Absence will create specific deficiency diseases in as soon as 2 weeks
Term
Omega 6 is
Definition
linoleic
Term
omega 3 is
Definition
alpha linolenic
Term
linoleic is
Definition
Omega 6
Term
alpha linolenic is
Definition
omega 3
Term
An essential FA deficiency of omega 6 linoleic acid will cause what?
Definition
Eczema, poor growth, petechiae (red, purple skin spots)
Term
Eczema, poor growth, petechiae (red, purple skin spots) are signs of
Definition
An essential FA deficiency of omega 6 linoleic acid
Term
An essential FA deficiency of omega 3 alpha linolenic acid will cause what?
Definition
neuro changes - numbness, blurred vision
Term
neuro changes - numbness, blurred vision are signs of?
Definition
An essential FA deficiency of omega 3 alpha linolenic acid
Term
What's that good FA that comes from fish oil?
Definition
Alpha linolenic omega 3
Term
what are the 2 fish oils
Definition
EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid)
Term
Walnuts, flaxseeds, and canola have what important fat?
Definition
omega 3 alpha linolenic acid
Term
What effect does omega 3 alpha linolenic acid have on the liver?
Definition
Decreases hepatic production of TGs (inhibits VLDL synthesis)
Term
Fat molecules terminate in a ____ at one and and a _____ at the other.
Definition
Carboxyl group (COOH), methyl group (CH3)
Term
Hydrogenation
Definition
The process of adding hydrogen (At the double bond) to unsaturated fatty acids to increase saturation and stability
Term
The process of adding hydrogen (At the double bond) to unsaturated fatty acids to increase saturation and stability
Definition
Hydrogenation
Term
Trans fats are pdts of the partial hydrogenation of
Definition
Polyunsaturated fats
Term
Partially hydrogenated fats probably means
Definition
Trans fats
Term
Trans fats are found in
Definition
MARGARINES, SHORTENINGS, AND FRYING FATS
(and a lil in milk fats)
Term
Y are trans fats bad???
Definition
They can influence membrane fluidity and could be harmful to cell fx
Term
CIS FAs
Definition
H on the same side of the double bond
Term
Medium chain triglycerides (MCTs)
Definition
Saturated fatty acids between 6-12 C long
Term
MCTs are naturally found in
Definition
milk fat, coconut oil, palm kernel oil
Term
milk fat, coconut oil, palm kernel oil contain
Definition
MCTs
Term
Most saturated fat
Definition
coconut oil
Term
Least saturated fat
Definition
palm oil
Term
Most monounsaturated fat
Definition
olive
Term
Least monounsaturated fat
Definition
sunflower
Term
Least polyunsaturated fat
Definition
sunflower
Term
Butter fats in order of predominance in butter
Definition
SAT, MUFA, PUFA
Term
Butter is mainly what kind of fat?
Definition
saturated
Term
Margarine fats in order of predominance in margarine
Definition
PUFA, MUFA, SAT
Term
Margarine is mainly what kind of fat?
Definition
PUFA
Term
Fx of fat
Definition
Energy, insulation, padding, delay gastric emptying
Term
Why does fat have more kcals/g?
Definition
Bc has less O2 + more C than CHO, which means more carbon atoms for oxidation
Term
Less than __% of kcals should be from fat.
Definition
30%
Term
How do you determine calories in alcohol that is not 200 proof (100%)?
Definition
(0.8)(proof)(oz)
Term
Winterized oil
Definition
will not crystallize when cold
Term
Give an example of a winterized oil
Definition
salad dressing
Term
What type of oil will not crystallize when cold?
Definition
Winterized oil
Term
How do you make winterized oil?
Definition
Chill it to 45 degrees. All the fat with high melting points will crystallize and can be filtered out.
Term
What does winterized oil look like?
Definition
Clear, not cloudy
Term
What 3 oils are winterized?
Definition
Corn, soy, and cottonseed
Term
What oil is NOT winterized?
Definition
Olive oil
Term
Olive oil is NOT...
Definition
winterized
Term
Corn, soy, and cottonseed ARE...
Definition
winterized
Term
Insensible water loss
Definition
skin, breathing; 0.8-1.2 L/d
Term
mEq calculation
Definition
(mg/atomic weight) x (# valence electrons)
Term
Extracellular electrolytes
Definition
Na+, Ca++, Cl-, HCO3- (bicarb)
Term
Intracellular electrolytes
Definition
K+, Mg++, P
Term
NaCl is what % Na?
Definition
40%
Term
Na is reabsorbed by
Definition
aldosterone
Term
aldosterone reabsorbs __.
Definition
Na
Term
Na is retained by__.
Definition
steroids
Term
Steroids retain__.
Definition
Na
Term
High K foods
Definition
banana, orange, tomato, potato, cantaloupe
Term
Aldosterone INCREASES excretion of
Definition
K
Term
Normal Na, K, Mg, P ranges
Definition
136-145 na
3.5-5 k
1.5-2.5 mg
3-4.5 Phos
Term
Osmosis
Definition
Fluid moves from less to more concentrated side of membrane
Term
Diffusion
Definition
Particles move from more to less concentrated side
Term
Explain albumin and fluid balance
Definition
Albumin at normal lvls in blood vessels draws water to it via osmosis. If albumin gets low, water is drawn out of blood vessels via osmosis, causing edema.
Term
Sx of dehydration
Definition
Nausea, dizziness, sunken eyes, fever, hyperventilation, excess sweating, [urine], dry inelastic skin, increase in solutes (Na, BUN), tachycardia, headache, fatigue, decreased appetite, rapid weight loss
Term
Best assessment parameter for fluid status?
Definition
Na. HyperNa: dehydrated. HypoNa: Overhydrated.
Term
Acid base balance
Definition
regulation of [H]
Term
releases H ions
Definition
acids
Term
Takes up H ions
Definition
bases
Term
Buffer
Definition
mix of acid and base components to protect against a strong acid or base
Term
Main buffers in body
Definition
Carbonic acid (H2CO3) and NaBicarb (NaHCO3)
Term
0-7 pH
Definition
acid
Term
7-14 pH
Definition
Base
Term
What organ controls the supply of carbonic acid (CO2 + water)?
Definition
lungs
Term
Hypoventilation causes the _____ of acid.
Definition
Retention
Term
Hyperventilation causes the ___ of acid
Definition
loss
Term
What organ controls bicarb (base)?
Definition
Kidneys
Term
How do the kidneys regular bicarb?
Definition
By regulating H ion secretion and bicarb reabsoption
Term
If kidneys retain bicarb,
Definition
lvl of base increases
Term
If kidneys excrete bicarb,
Definition
lvl of base decreases
Term
Respiratory acidosis
Definition
retention of acid by lungs through hypoventilation. kidneys increase reabsorption of base to compensate.
Term
Respiratory alkalosis
Definition
Loss of carbonic acid by lungs through hyperventilation. Kidneys excrete base to compensate.
Term
Metabolic acidosis
Definition
Can be caused by uncontrolled DM, starvation. Kidneys produce/retain H OR excrete too much base. Lungs compensate by increasing respiration to remove CO2 and make blood more basic.
Term
Metabolic alkalosis
Definition
Can be caused by diuretics, vomiting. From excess H losses from kidney or kidneys retaining base. Lungs compensate by decrease ventilation to retain CO2 to increase acidity.
Term
If the PCO2 is WNL it tells you the lungs are working ___.
Definition
Normally
Term
If the HCO3 is WNL it tells you the kidneys are working ___.
Definition
Normally
Term
How much weight should a normal weight female gain during pregnancy?
Definition
25-35#
Term
How much weight should an underweight female gain during pregnancy?
Definition
28-40#
Term
How much weight should an overweight female gain during pregnancy?
Definition
15-25#
Term
How much weight should an obese female gain during pregnancy?
Definition
11-20#
Term
What 2 groups of females need to strive to gain the upper end of the weight range during pregnancy in order to reduce risk?
Definition
Black and very young females
Term
How many extra kcals in 1st trimester?
Definition
0
Term
How many extra kcals in 2nd trimester?
Definition
+340kcals
Term
How many extra kcals in 3rd trimester?
Definition
+425kcals
Term
How many extra kcals in 1st 6m breastfeeding?
Definition
+330kcals
Term
How many extra kcals after 6m breastfeeding through 12m?
Definition
+400kcals
Term
Rate of weight gain 1st trimester
Definition
1#/m
Term
Rate of weight gain after 1st trimester
Definition
1#/wk
Term
What 3 minerals do pregnant teenagers need extra of?
Definition
Fe, Ca, Zn
Term
What 2 things should pregnant women supplement in 2nd and 3rd trimester?
Definition
Fe and folate
Term
Total folic acid needed daily during pregnancy
Definition
600mcg. 200 from food, 400 from supplement
Term
Why is linolenic omega 3's needed during pregnancy?
Definition
Develop fetal nervous system
Term
Normal weight infant in g
Definition
2500-4000g
Term
Extremely low bw infant in g
Definition
<1000g
Term
AGA = Appropriate for gestational age means between what %iles?
Definition
10-90th
Term
Min fat g /d for infants
Definition
30g
Term
Water needs for infants
Definition
125-155mL/kg
Term
Neonate age range
Definition
birth to 1m
Term
Human milk is how many kcals/oz
Definition
20?
Term
What hormone moves milk through ducts?
Definition
Oxytocin
Term
Colostrum has more ___ and less___.
Definition
Protein, fat/CHO
Term
Breast fed infants need how much supplemented VD?
Definition
400IU/d
Term
Infant formula has more ___ and ___ and ___ that breastmilk.
Definition
protein, Fe, VD
Term
Don't feed infants this type of formula:
Definition
Cow's milk based
Term
Fetal iron stores start to decrease at
Definition
3-4m
Term
What 2 foods should not be given to infants in the 1st year of life?
Definition
Honey, cows milk
Term
At ___ old you can give infants food they can hold with their entire hand (palmar grasp).
Definition
8m
Term
At ___ old you can give infants food they can hold with their thumb and pointer finger (pincer grasp).
Definition
9-12m
Term
Do not give low/nonfat milk to infants before __ years old.
Definition
2 years
Term
Pregestimil is an infant formula for infants who can't tolerate what 2 formula types?
Definition
Cowsmilk/soy based
Term
What age ranges does growth slow down?
Definition
1-3y, 7-10y
Term
What age ranges does growth speed up?
Definition
Infants, 4-6y, teenagers
Term
Limit fruit juice to ___/d.
Definition
4oz
Term
Kids needs ____min PA/d.
Definition
60 min
Term
What period of childhood has the potential for the most deficiencies?
Definition
teens
Term
Weight for age cannot be used in nutrition assessment bc it does not include
Definition
height
Term
Head circumference can be measured until age
Definition
3
Term
Laying down height can be used until age
Definition
2
Term
A growth measure meant >25%ile points from the current growth trend is likely d/t
Definition
Human error
Term
Newborn weight loss regained w/in
Definition
fortnight
Term
Down syndrome growth charts are
Definition
outdated, do not use
Term
Lack of fiber in infants can lead to constipation and potentially
Definition
FTT
Term
Macro % kcal ranges
Definition
CHO 45-65%, Fat 20-35%, Pro 10-35%
Term
Pro % kcal range
Definition
10-35%
Term
Fat % kcal range
Definition
20-35%
Term
CHO % kcal range
Definition
45-65%
Term
Fiber needs men/women
Definition
38, 25
Term
General fluid needs
Definition
35mL/kg or 1ml/kcal
Term
For old people, calorie needs ___ and pro needs ___.
Definition
Decrease, stay the same
Term
Fluid min
Definition
1500mL/d
Term
Elderly might need these 2 minerals supplemented
Definition
Ca/Fe
Term
Elderly are more susceptible to constipation for 2 reasons:
Definition
Decreased gastric motility and decreased HCl secretion in stomach
Term
Decreased gastric motility and decreased HCl secretion in stomach mean the elderly are more susceptible to
Definition
constipation
Term
Encourage ___ rich foods in the elderly.
Definition
folate
Term
Things adults need while working out
Definition
water, CHO, Na
Term
What effect does CHO loading have?
Definition
Stores 2-3x the normal amount of muscle glycogen in muscles
Term
Primary energy source during rest and normal activities
Definition
fat
Term
During low-mod activity, ___ is the primary energy source.
Definition
fat
Term
During hard exercise, ___ is the primary source of energy, but now ___ is also needed.
Definition
Fat, CHO
Term
Muscle glycogen is depleted ___ hours after hard continuous exercise.
Definition
2-3 hours
Term
Creatine supplements ____ enhance endurance.
Definition
DO NOT
Term
Supplements are not allowed to display what claims?
Definition
Preventure/cure of conditions
Term
Botanicals are classified as dietary supplements by what act?
Definition
DSHEA: Dietary Supplement Health and Education Act 1994
Term
What is allowed to be noted in supplements?
Definition
Any potential physiological effect
Term
What supplements to avoid when on warfarin?
Definition
garlic, gingko, ginseng, ginger
Term
Avoid garlic, gingko, ginseng, ginger when on:
Definition
warfarin
Term
What supplements to avoid because of the liver?
Definition
Comfrey, kava, valerian root
Term
Avoid comfrey, kava, valerian root w/
Definition
liver problems
Term
What 2 things mess up birth control?
Definition
St. john's wort, ABX
Term
Avoid what supplements with diuretics?
Definition
Ephedra, saw palmetto, licorice root
Term
Avoid Ephedra, saw palmetto, licorice root w/ what drugs?
Definition
diuretics
Term
Avoid taking which supplement longer than 2 months?
Definition
Echinacea
Term
fundus
Definition
upper stomach
Term
Most stomach digestion occurs in the ___ region.
Definition
Pyloric (lower)
Term
The hepatic duct from the liver joins with the ___ duct from the ___.
Definition
cystic duct, gallbladder
Term
Bile is produced in the ___.
Definition
Liver
Term
Bile is stored in the
Definition
gallbladder
Term
The liver stores ___ and synthesizes ____.
Definition
glycogen, glucose
Term
The pancreas lies between the ___ and the ___.
Definition
Duodenum, stomach
Term
CHO digestion is limited in the ___ and really continues in the ___.
Definition
stomach, small intestine
Term
Protein digestion begins in the ___.
Definition
stomach
Term
When fat enters the duodenum, ___ is released.
Definition
CCK - cholecystokinin
Term
CCK - cholecystokinin
Definition
stimulates gallbladder to release bile, stimulates pancreas
Term
Secretin stimulates ___ and inhibits ___.
Definition
pancreatic juice (bicarb), gastric acid
Term
What inhibits gastric acid and stimulates pancreatic juice (bicarb)?
Definition
Secretin
Term
What is released from the intestines when fat/CHO are ingested?
Definition
glucagon-like peptide 1 (GLP-1)
Term
What does glucagon-like peptide 1 (GLP-1) do after it is stimulated to be released p fat/CHO ingestion?
Definition
Stimulates insulin synthesis and release
Term
What compound stimulates insulin synthesis and release?
Definition
glucagon-like peptide 1 (GLP-1)
Term
Chyme is made in the
Definition
stomach
Term
Gastric emptying of a meal takes between
Definition
2-6 hours
Term
What 2 types of food slow gastric emptying?
Definition
Complex CHO and fat
Term
What 2 types of food empty from the stomach at the same rate?
Definition
Protein and non complex CHO
Term
Acidic chyme enters the duodenum and is neutralized by what from where
Definition
bicarb, pancreas
Term
Most digestion is completed by the time food hits the
Definition
middle of the jejunum
Term
Large intestine absorbs
Definition
water, salts, vitamins synthesized by bacteria
Term
What vitamins are synthesized by bacteria in the large intestine?
Definition
VK, B12, thiamin, riboflavin
Term
What do VK, B12, thiamin, riboflavin have in common?
Definition
They are synthesized by bacteria in the large intestine.
Term
The colon converts malabsorbed CHO/fibers into
Definition
short chain FAs
Term
Examples of short chain FAs produced in the colon.
Definition
acetate, butyrate, propionate, lactate
Term
short chain FAs produced in the colon stimulate what?
Definition
water/Na absorption INTO the colon
Term
Where are acetate, butyrate, propionate, lactate produced?
Definition
colon
Term
Where are short chain FAs produced?
Definition
colon
Term
p simple sugars are absorbed through the small intestine, they travel to ___, where they are ___.
Definition
liver, converted to glucose or glucogen
Term
__% of any ingested amount of protein can be turned into CHO
Definition
58%
Term
For a protein molecule to be converted into glucose (of which it has to have the right kind of AA), what has to happen?
Definition
Deamination
Term
What is the most glucogenic AA?
Definition
Alanine
Term
___% of fat, the ____ part, can be converted to glucose.
Definition
10%, glycerol backbone
Term
_____ and ____ do not contribute to the body's supply of glucose.
Definition
Fatty acids, muscle glucogen
Term
What controls blood glucose level?
Definition
Hormones
Term
What hormones control blood glucose level?
Definition
insulin, glucagon, glucocorticoids, epi, growth hormone
Term
Insulin is produced by
Definition
beta cells of pancreas
Term
Insulin's effects
Definition
increased cell permeability to glucose.
Term
Glucagon is a hormone that
Definition
induces glycogenolysis
Term
What hormone induces glycogenolysis?
Definition
Glucagon, epi
Term
Glucocorticoids are a hormone that
Definition
stimulates gluconeogenesis from protein
Term
What hormones stimulates gluconeogenesis from protein?
Definition
Glucocorticoids
Term
gluconeogenesis is stimulated by what hormones?
Definition
Glucocorticoids
Term
Epi stimulates
Definition
glycogenolysis
Term
During catabolic stress, epi
Definition
decreases insulin release so blood glucose rises
Term
What suppresses insulin release during catabolic stress so blood glucose rises?
Definition
epi
Term
insulin antagonist
Definition
renders insulin inactive
Term
growth hormone ACTH is an
Definition
insulin antagonist
Term
End pdts of metabolism
Definition
Energy, CO2, water
Term
Glycolysis occurs in the
Definition
cytoplasm
Term
glycolysis produces _____ for the ___.
Definition
pyruvate, kreb's cycle
Term
Glycolysis can use but does not require
Definition
O2
Term
end ptd of aerobic glycolysis
Definition
pyruvate
Term
end ptd of anaerobic glycolysis
Definition
lactate
Term
Lactate is the end pdt of
Definition
anaerobic glycolysis
Term
pyruvate is the end pdt of
Definition
aerobic glycolysis
Term
NADPH has what vitamin
Definition
Niacin
Term
Phos and Mg form
Definition
glucose 6 phosphate
Term
glucose 6 phosphate turns into
Definition
pyruvic acid
Term
pyruvic acid turns into ___ for muscle contractions when O2 needs aren't being met (exercise)
Definition
lactic acid
Term
MOST of pyruvic acid is converted to form
Definition
acetyl coA
Term
____ is the MAIN substrate for krebs cycle
Definition
pyruvate
Term
The TCA tricarboxylic acid cycle is also known as
Definition
krebs cycle
Term
acetyl coA is formed from
Definition
pyruvic acid, or oxidation of FAs, or degradation of certain AAs
Term
90% of the bodys atp is produced from
Definition
krebs cycle
Term
______ from CHO is needed to start the krebs cycle
Definition
oxaloacetate
Term
If there is not enough oxaloacetate coming in from CHO to combine w/ acetyl coA for krebs cycle, acetyl coA will
Definition
be diverted to form ketone bodies for energy
Term
biochemically, ketone bodies are formed when
Definition
there is not enough CHO coming in to form oxaloacetate and combine with acetylcoA for krebs cycle
Term
full oxidation of 1 molecule of glucose provides ___ atp.
Definition
38 atp
Term
___is needed for the transport of AA
Definition
Pyridoxine
Term
3 branched chain AA
Definition
Valine, leucine, isoleucine
Term
___ is released from muscle during exercise so liver can turn it into glucose
Definition
alanine
Term
alanine is released from muscle during exercise so
Definition
the liver can turn it into glucose
Term
____ can be synthesized from phenylalanine
Definition
tyrosine
Term
tyrosine can be synthesized from
Definition
phenylalanine
Term
Positive nitrogen balance means
Definition
net gain in protein during periods of growth
Term
Negative nitrogen balance means
Definition
net loss of protein
Term
A biological value of 100% for eggs means
Definition
100% of the nitrogen in eggs is absorbed
Term
1st step of protein catabolism
Definition
deamination
Term
2nd step of protein catabolism
Definition
NH2 converted to NH3 (toxic ammonia)
Term
3rd step of protein catabolicm
Definition
NH3 (ammonia) converted to urea and excreted by kidneys
Term
deamination of protein occurs where?
Definition
liver
Term
transamination
Definition
transfer of an amino group to a ketoacid to form a new amino acid
Term
hormones that stimulate protein anabolism?
Definition
Insulin, pituitary growth hormone, thyroid hormone, testosterone
Term
hormones that stimulate protein catabolism?
Definition
glucocorticoids (adrenal steroids)
Term
glucocorticoids (adrenal steroids) can stimulate
Definition
protein catabolism
Term
end pdts of fat digestion
Definition
monoglycerides, diglycerides, glycerol, FAs
Term
Which end pdts of fat digestion can be absorbed directly into portal blood without forming chylomicrons first?
Definition
SCFAs (<12 C), some phospholipids, glycerol
Term
Which end pdts of fat digestion need to form chylomicrons to be absorbed?
Definition
monoglycerides, diglycerides, long chain FAs
Term
An example of a lipoprotein is a
Definition
chylomicron
Term
Cholesterol is found in ___ cells.
Definition
all
Term
Cholesterol is absorbed w/ either of these 2 things
Definition
bile salts, cholesterol esterase
Term
Cholesterol is excreted by body from
Definition
liver as bile
Term
FAs + glycerol =
Definition
TGs
Term
The liver synthesizes this but should NOT store it (could technically be 2 things)
Definition
fat, also bile
Term
Lipoproteins transfer FAs out of the...
Definition
liver
Term
Oxidation of fats forms ___ which enters the ___.
Definition
acetyl coA, krebs cycle
Term
Lipolysis is triggered by what hormones?
Definition
growth hormone, glucagon, glucocorticoids, thyroxine, epi, ACTH
Term
ACTH increases the rate of
Definition
fat mobilization
Term
lipogenesis is stimulated by the hormone
Definition
insulin
Term
2 acetyl coAs can form
Definition
ketone body
Term
fat + CHO needed to form
Definition
acetyl coA
Term
"normal fat metabolism"
Definition
enough CHO to get through krebs cycle
Term
"abnormal fat metabolism"
Definition
not enough CHO to get through krebs cycle, so ketones
Term
Active transport (requiring ATP) is how __________ are absorbed
Definition
most nurtients
Term
___ and ___ are absorbed by simple diffusion
Definition
Some water, electrolytes
Term
carrier-facilitated transport is called
Definition
Passive diffusion
Term
___ are absorbed by passive diffusion (carrier-facilitated transport) .
Definition
water soluble nutrients
Term
diffusion is from ____ to ____ concentration./
Definition
Higher to lower
Term
Things that help absorb FSV also help absorb
Definition
fat
Term
Thiamin absorption is increased by
Definition
acid
Term
Riboflavin absorption is increased by
Definition
phos
Term
B12 absorption is increased by
Definition
intrinsic factor, HCl
Term
Ca absorption is increased by
Definition
VD, lactose, acid
Term
Fe absorption is increased by
Definition
HCl, acidic fruits, Ca (bcuz it binds oxalates)
Term
Feeding and satiety center
Definition
hypothalamus
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