Shared Flashcard Set

Details

Influenza
Overview
38
Microbiology
Professional
09/16/2013

Additional Microbiology Flashcards

 


 

Cards

Term
Type A (70%)
Definition
16 H, 9 N; moderate to severe illness; all age groups; humans and other animals
Term
Type B (30%)
Definition
milder epidemics; humans only; primarily affects children
Term
Type C
Definition
rarely reported in humans; no epidemics or significant disease
Term
gradual mutation; may result in epidemic, widespread illness
Definition
Antigenetic drift
Term
more precipitous genetic recombo of 2 different strains, occurs at unpredictable intervals; pandemic may result
Definition
Antigenetic shift
Term
new influenza virus; animals as reservoir and infect a variety of hosts; efficiently transmitted between humans
Definition
Components of Pandremic
Term
infection is maintained in population
Definition
endemic
Term
new cases of disease exceeding what is expected
Definition
epidemic
Term
epidemic that is spreading through populations across large region/worldwide; non-stable
Definition
pandemic
Term
Primary spread of influenza
Definition
inhale droplets (sneezing, coughing, talking); up to 6 feet away
Term
Minor spread of influenza
Definition
direct contact; indirect contact (possibly)- stethoscope, computer keyboards, phones
Term
Respiratory transmission of virus -->
Definition
replication in respiratory epithelium with subsequent destruction of cells
Term
Viral shedding in respiratory secretions
Definition
can occur for 5-10 days
Term
Contagious:
Definition
up to 5-7 days after symptoms begin (longer in children)
Term
systemic symptoms
Definition
due to body's immune reaction to virus
Term
Time from infection to symptoms
Definition
2 days (range 1-4 days)
Term
Influenza symptoms (abrupt onset!)
Definition
fever, cough, sore throat, shortness of breath, myalgia, headache, malaise, rhinitis or stuffy nose, vomiting and diarrhea
Term
highest risk of death
Definition
65 years and < 5 years
Term
who are we most worried about for influenza?
Definition
children <5, esp <2 years; pregnant, elderly; pulmonary, neurological conditions; heart disease, blood, metabolic disorders; weakened immune system; persons <19 years on long term aspirin therapy
Term
quadrivalent
Definition
put in 4 different strains into vaccine
Term
trivalent
Definition
put in 3 strains into vaccine
Term
IM Flu Vaccines (Fluzone)
Definition
Single use syringes vials, multi-dose vials; 0.25 mL IM 6-35 months; 0.5 mL IM greater than 35 months
Term
IM Flu Vaccine SEs (Fluzone)
Definition
injection site reaction; low grade fever; aches
Term
Fluzone-HD
Definition
Quad strength inactivated flu vaccine; for 65 years and older option
Term
Fluzone-HD dosing
Definition
0.5 mL IM x 1
Term
Flumist
Definition
Intranasal single-use spray; live attenuated cold-adapted virus; side effects include runny or stuffy nose, headache, sore throat, cough
Term
Flumist Dosing
Definition
0.1 mL in 1 nostril, then 0.1 mL in other
Term
Fluzone Intradermal
Definition
0.1 mL; 18-64 years of age
Term
2 A strains and 2 B strains;
Definition
Quadrivalent (QIV) vaccines
Term
FluBlok
Definition
Approved in Jan 2013; 18-49 years; Trivalent, egg-free; shorter shelf life (16 weeks from production)
Term
Flucelvax
Definition
cell-culture based vaccine; trivalent; does not contain egg proteins; assess egg allergy history
Term
standard vaccine
Definition
inactivated trivalent
Term
egg free options
Definition
cell culture and recombinant vaccines
Term
thimerosal
Definition
preservative; 50% ethylmercury (not methylmercury)-- actively excreted in gut
Term
tamiflu
Definition
influenza A and B; Adults: Prophylaxis 75 mg daily; treatment 75 mg BID
Term
Relenza
Definition
Influenza A and B; prophylaxis >4 yrs 2 inhalations daily; treatment >6 years 2 inhalations BID
Term
Relenza SEs
Definition
cough, bronchospasm, sinusitis, dizziness
Term
Antivirals Duration
Definition
Txt: 5 days, longer for severely ill can be considered Prophylaxis: 7 days after exposure.
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