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Inflammatoryand Demyelinating disorders of CNS
Inflammatoryand Demyelinating disorders of CNS
14
Medical
Graduate
04/18/2010

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Term
What is Pott's disease?
Definition
TB of the spine
Term
Treponema pallidum causes chronic bacterial menigitis aka
Definition
Neurosyphillis
-Meningovascular neurosyphilis
-Paretic neurosyphylis
-Tabes dorsalis (inflammation of the dorsal roots causing impaired joint position sense and loss of pain sensation whic leads to joitn damage -charcot joints)
Term
Viral meningoencephalitis is most commonly caused by
Definition
arboviridiae
Term
The following describes infection by this virus:
virus resides latent in trigeminal ganglion
Reactivation may cause herpes encephalitis which is necrotizing and localized to the temporal lobes
cold sores
Definition
Herpes simplex virus 1
Term
The following describes infection by this virus:
infects infants via birth canal (therefore C section for infected mums)
causes necrotizing encephalitis
Definition
HSV2
Term
The following describes infection by this virus:
affects older adults
reactivation of chickenpox (varicella)
v v v painful
causes a radiculopathy- pain along a dermatome
Definition
herpes zoster (shingles)
Term
The following describes infection by this virus:
causes encephalitis in fetuses infected in utero and in immunocompromised adults, esp AIDS patients
Definition
CMV
Term
The following describes infection by this virus:
causes viral encephalitis
virus travels via peripheral nerve to spinal cord to brain
Destruction of brainstem neurons causes "hydrophobia"
Negri bodies are pathognomonic cytoplasmic eosinophilic inclusions in pyramidalneurons
Definition
Rabies caused by Rhabdovirus (enveloped ssRNA virus)
Term
The following describes infection by this virus:
occurs in immunocompromised hosts
causes progressive multifocal leucoencephalopathy
dementia, wekaness, ataxia
no effective tx, death within 6 mths
virus infects oligodendroglia and causes demyelination
Definition
polyoma virus (JCV)
Term
The following describes infection by this virus:
causes subacute sclerosing panencephalitis (SSPE)
rare complication in live vaccine recipients
elevated cirus Ab titers found in the CSF
Definition
Measles virus
Term
The following describes infection by this virus:
LMNs show chromatolysis and neuronophagia
rarely invades CNS, causes mild gastroenteritis in most people
Definition
poliomyelitis caused by polio virus
Term
The following describes infection by this virus:
Direct effects:
Meningoencephalitis
vacuolar myelopathy (spinal cord)
myopathy and peripheral neuropathy
Indirec effects:
opportunistic infection and CNS lymphoma (EBV)
Viral infections of CNS very common, bacterial infections of CNS in AIDS rare
Toxoplasma gondii infections v common, often treated emprirically
Definition
HIV-1
Term
Ring abscess in HIV patient, think
Definition
Cerebral Toxoplasmosis
(must be distinguished from CNS lymphoma, TB, fungal infection)
Term
This CNS disorder is:
caused by rapid correcio of hyponatremia
alcoholics and debiliated patients are susceptible
Definition
Central pontine myelinolysis
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