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| one of the chemoattractants; include IL8, MCP-1, and C3a |
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| a compartmentalized collection of purulent inflammation (pus) and necrotic tissue deep within tissue or a body cavity; most often the result of a pyogenic bacterial infection; healing with granulation tissue and/or fibrosis occurs at the outer margin encircling the zone of necrosis and inflammation |
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| the accumulation of protein-rich fluid in the tissues as a result of increased vascular permeability |
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| neutrophils and monocytes are induced by chemoattractants from the site of injury to move out of the vessel through the endothelial gaps; happens within minutes and is maximal at 6-24 hours after injury onset |
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| a protein-rich fluid that includes many of the mediators, immunoglobulins, and key ingredients required for the healing of the injury |
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| watery, relatively poor in cells and protein; commonly seen in early bacterial infectiosn |
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| pus; a thick fluid composed of leukocytes, perdominantly neutrophils, and liquefied tissue, commonly seen with pyogenic infections like staphylococci |
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| moderate-extensive protein content, with fibrin formation; commonly seen in serous sacs such as pleural and pericardial space |
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| any exudate that contains blood, commonly seen in fulminating suppurative inflammation |
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| a high molecular-weight glycoprotein derived from plasma, later produced by proliferating endothelial cells and fibroblasts; binds collagens, proteoglycans, and other macromolecules to cell surfaces to form a matrix; also a potent chemoattractant for fibroblasts |
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| formed at the second stage of repair, includes three predominate cell types: macrophages, endothelial cells, myofibroblasts |
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| nodular aggregates of macrophages with variable numbers of associated lymphocytes; nodules are usually about 1 mm, but can coalesce to form substantial masses |
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| firmly binding ligands expressed on the surfaces of leukocytes and endothelial cells; the mechanism by which neutrophils and monocytes stop rolling and become fixed to the endothelium; include VCAM, ICAM, PECAM, LFA, and Mac-1 |
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| cellular ingestion of microorganisms, cell debris, and particulate foreign matter; involves several steps, the first 3 are fueled by anaerobic glycolysis |
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| loosely binding ligands expressed on surfaces of leukocytes and endothelial cells which make them "sticky"; includes endothelial-E selectin and platelet-P and leukocyte-L selectins |
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| lysosomal granule contents |
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| arachidonic acid metabolites |
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| oxygen-derived free radicals |
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| platelet activating factor |
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| a cell-derived mediator of acute inflammation; causes vasodilation and increased permeability; platelet activation with multiple effects |
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| platelet activating factor |
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| oxygen-derived free radicals |
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