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Inflammation Mediators & Their Actions
Pricipal mediators of inflammation and their actions
11
Medical
Undergraduate 1
11/24/2011

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Term
Histamine
Definition
Vasodilation
Increases vascular permeability
Endothilial activation
Term
Serotonin
Definition
Vasodilation
Increases vascular permeability
Term
Prostaglandin
Definition
Vasodilation
Pain
Fever
Term
Leukotrienes
Definition
Increases vascular permeability
Chemotaxis
Leukocyte adhesion & activation
Term
Platelet Activating Factor (PAF)
Definition
Vasodilation
Increases vascular permeability
Chemotaxis
Leukocyte activation
Degranulation
Oxidative burst
Term
Reactive Oxygen Species (ROS)
Definition
Killing of microbes
Tissue Damage
Term
Nitric Oxide
Definition
Vascular smooth muscles relaxation
Killing of microbes
Term
Cytokines (IL - TNF)
Definition
Local endothelial activation (expression of adhesion molecules)
Systemic acute-phase response in severe infections
Septic shocks
Term
Kinins
Definition
Vasodilation
Increases vascular permeability
Smooth muscles contraction
Pain
Term
Complement
Definition
Vasodilation (mast cells stimulation)
Leukocyte chemotaxis & activation
Opsonization
Term
Proteases activated during coagulation
Definition
Endothelial activation
Leukocyte recruitment
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