Term
| Lipoxygenase metabolites (4) |
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Definition
1. Leukotrienes
2. Lipoxins
3. HPETEs
4. HETEs |
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Term
| Cyclooxygenase metabolites (3) |
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Definition
1. Prostaglandins
2. Prostacyclin
3. Thromboxane |
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Term
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Definition
Fatty acid metabolites of arachidonic acids
Paracrine or autocrine hormones synthesized on demand in response to hormones, drugs, or stressors. |
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Term
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Definition
Used clinically to maintain maternal/fetal blood flow
Maintains PDA
Impotence? |
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Term
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Definition
| PGE1 analog marketed to promote ulcer healing |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Synthesized by HPETE in mast cells and PMNs
1. Meditate inflammation
2. Cx chemotaxis
3. Activate phagocytosis |
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Term
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Definition
| Inh prostaglandin formation by blocking cyclooxygenases |
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Term
| Acetylsalicylic acid (aspirin) |
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Definition
1. Analgesia w/o tolerance
2. Antipyresis
3. Anti-inflammatory actions
4. Reduces incidence of acute MI
5. Topical application for warts |
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Term
| Acetylsalicylic acid toxicity |
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Definition
1. Epigastric distress (N/V)
2. Gastric ulceration, hemorrhage
3. Prolonged bleeding
4. Hypersensitivity rxns
5. Reye's syndrome
6. Hepatotoxicity
7. Acute renal insufficiency
8. Uric acid sec dec w small doses, inc w large doses |
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Term
| Acetylsalicylic acid effects on respiration |
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Definition
Therapeutic doses timulates resp cxing resp alkalosis => Inc renal excretion of bicarb
Toxic doses depress resp resulting in acidosis => dec renal excretion of organic acids and inc lactic acid production |
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Term
| Acetylsalicylic acid contraindications (6) |
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Definition
1. Ulcer pts
2. Allergic pts
3. Clotting DO
4. Pregnancy
5. Gout
6. Children |
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Term
| Acetaminophen non-effects |
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Definition
1. NOT anti-inflammatory
2. NO effect on bleeding time
3. NO alterations in acid-base balance
4. Minimal effects on GI
5. NO uricosuric effects |
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Term
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Definition
1. Analgesia
2 . Antipyresis |
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Term
| Acetaminophen side effects (4) |
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Definition
1. Fatal hepatic necrosis w acute overdose
*Rx w N-Acetylcysteine
2. Skin rash
3. Mucosal lesions
4. Rarely leukopenia |
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Term
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Definition
COX2-selective inhibitor
Primarily used to rx RA or OA due to ability to inh inducible form of COX2 w/o side affects of traditional NSAIDS, due to minimal effects on normal fx of prostaglandins |
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Term
| Celecoxib contraindications |
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Definition
Pts w sulfa sensitivity
Also inc CV risk |
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Term
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Definition
Antineoplastic rx used to rx only SEVERE RA due to numerous side effects including:
Hepatotox, agranulocytosis, leukopenia, anemia, thrombocytopenia, N/V, chills, fever |
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Term
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Definition
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Term
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Definition
| Hepatotox, agranulocytosis, leukopenia, anemia, thrombocytopenia, N/V, chills, fever |
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Term
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Definition
Binds TNFa preventing interaction w receptors
Used to rx RA |
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Term
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Definition
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Term
| Side effects of Etanercept, Adalimumab, and Infliximab |
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Definition
1. Pain, swelling, itching
2. Infusion rxn (rash, fever, chills)
3. INFXN
4. Contraindicated in sepsis |
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Term
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Definition
| Bind to CD4 inactivating T-Cells |
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Term
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Definition
| Used to rx acetaminophen OD |
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Term
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Definition
| Prostanoid used to facilitate labor by promoting ripening and dilation of the cervix |
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Term
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Definition
| NSAID w marked anti-infl action, but high toxicity |
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Term
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Definition
| NSAID w twice daily dosing |
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Term
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Definition
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Term
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Definition
Used for relieving acute Gout and effective prophylactically
Not uricosuric |
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Term
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Definition
| Inh migration of granulocytes to inflamed area |
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Term
| Colchicine side effects (4) |
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Definition
1. N/V
2. Diarrhea
3. Abd pain
4. Inc incidence of blood dyscrasias w prolonged use |
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Term
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Definition
Inc excretion of uric acid by dec resorption to Rx Gout
Must drink lots of H2O |
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Term
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Definition
Inc excretion of uric acid by dec resorption to Rx Gout
Must drink lots of H2O |
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Term
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Definition
Reduce formation of uric acid by inh XANTHINE OXIDASE
Rx Gout |
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