Term
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Definition
Glucocorticoid used for acute transplant rejection and other immunosuppressive uses
Long term use limited by toxicity |
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Term
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Definition
Potent immunosuppressant w same mechanism as cyclosporine, except it binds FKBP
Used for transplantation and rescue therapy |
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Term
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Definition
Calcineurin inhibitor used for organ transplants in combo w glucocorticoids, and for rheumatic arthritis
Binds to cyclophilin and inhibits production of IL-2 by blocking dephosphorylation of NFAT by calcineurin |
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Term
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Definition
Binds to FKBP, but does not inh calcineurin
Blocks IL-2 rec signaling and arrests cell division
Used for prophylaxis in organ transplant |
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Term
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Definition
Prodrug of PURINE ANALOG mercaptopurine which INH GENE TRANSLATION
Used for immunosuppression |
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Term
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Definition
| Prodrug of mycophenolic acid with higher bioavailability |
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Term
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Definition
Used for induction of immunosuppression and acute renal rejection
Can be used for withdrawal of calcineurin inhibitors |
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Term
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Definition
| Prophylaxis for renal transplants w other immunosuppressants |
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Term
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Definition
| Prophylaxis for renal transplants w other immunosuppressants |
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Term
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Definition
| Used for tranplant rejection w glucocorticoids and calcineurin inh, but not azathioprine |
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Term
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Definition
Folate analong
Anti-cancer
Rh arthritis
GVHD
Cytotoxic and anti-infl activity |
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Term
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Definition
| Indicated for organ transplant rejection |
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Term
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Definition
Humanized IgG1 mAb against CD11a chain of LY Ag
Blocks T-cell adhesion
Used for psoriasis |
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Term
| Cyclosporine toxicity (2) |
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Definition
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Term
| Cyclosporine pharmacokinetics |
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Definition
Metabolized by P450 3A (extensive rx interactions)
**Grapefruit and juice block CYP3A |
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Term
| Tacrolimus pharmacokinetics |
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Definition
| Metablized by CYP3A (same interactions as cyclosporine) |
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Term
| Tacrolimus adverse effects (2) |
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Definition
1. NEPHROTOXICITY
2. neurotoxicity (HA, seizures, tremor) |
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Term
| Sirolimus adverse effects |
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Definition
1. Hyperlipidemia
2. Leukopenia
3. Thrombocytopenia
*No nephrotoxicity, but cannot be given w Tacrolimus or cyclosporine |
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Term
| Sirolimus pharmacokinetics |
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Definition
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Term
| Azathiprine adverse effects |
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Definition
Bone marrow suppression
Inc susceptibility to infxn |
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Term
| Mycophenolic acid mechanism |
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Definition
Inh inosine monophosphate dehydrogenase (the rate limiting enzyme in guanosine formation)
Preferntially affects LYMPHOCYTES which depend on IMPDH for purine synth
Mycoph. acid preferentially inh Type II ImpDH which is highly expressed in LY |
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Term
| Anti-thymocyte Globulin mechanism |
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Definition
| Ab to T-cell antigens that deplete circulating LY |
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Term
| Anti-thymocyte Globulin side effects |
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Definition
| 1. Cytokine release syndrome (fever, HA, tremor, N/V, malaise) |
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Term
| Muromonab-CD-3 (OKT3) mechanism |
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Definition
| Ab against human CD3 depletes T-Cell pool |
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Term
| Muromonab-CD-3 (OKT3) side effects |
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Definition
1. Cytokine release syndrome
2. Pulmonary edema
3. CV collapse
4. Arrythmias |
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Term
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Definition
| Humanized anti-CD25 mouse Ab binds to IL-2 rec w less affinity than basiliximab |
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Term
| Daclizumab side effects (2) |
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Definition
1. Infxn
2. Anapyylactic rxns |
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Term
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Definition
| Humanized anti-CD25 mouse Ab binds to IL-2 rec w greater affinity than daclizimab |
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Term
| Basiliximab side effects (2) |
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Definition
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Term
| Hyperacute organ rejection |
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Definition
Preformed Ab react to donor Ag
Minutes to hors
Prevented by blood type matchin |
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Term
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Definition
Adaptive immune reponse to donot Ag w cytotoxic T cells
Weeks to months
Immunosuppression effective |
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Term
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Definition
Most common pathology in organ trans
Chronic infl by T-cells response
No current Rx |
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Term
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Definition
Implanted immune cells react to host
Rx with immunosuppression |
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