Term
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Definition
| Synthetic PGE1 used to maintain patency of ductus arteriousus |
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Term
| PGE and PGI2 effects (lung) |
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Definition
| dilate bronchioles (TXA2 constricts) |
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Term
| PGE and PGI2 effects (Cardiovascular) |
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Definition
| Dilate coronary vessels and decrease BP |
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Term
|
Definition
| ^ BP, constricts coronary vessels, and causes platelet aggregation |
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|
Term
| PGE and PGI2 effects (GI) |
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Definition
| Inhibit gastric acid and pepsin, increase mucous secretions (protective) |
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Term
|
Definition
| PGE1 analog used to promote ulcer healing (inhibit gastric acid and pepsin w/ ^ mucous) |
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Term
| PGE2 (repoductive system) |
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Definition
| Relaxes non-pregnant uterus (contracts pregnant) |
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Term
| PGF2alpha effects (Reproductive) |
|
Definition
-Contracts pregnant and non-pregnant uterus
-causes corpus luteum to lyse |
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Term
| PGE2 and PGF2 (as treatment) |
|
Definition
| Used to induce abortion and to control post-partum hemorrhage |
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Term
|
Definition
| Facilitates labor by ripening and dilating cervix |
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Term
|
Definition
| Block actions of leukotrienes (inflammation, bronchoconstriction, chemotaxis) used to treat asthma |
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Term
|
Definition
| Block actions of leukotrienes (inflammation, bronchoconstriction, chemotaxis) used to treat asthma |
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Term
|
Definition
-Can worsen gout at low doses
@therapeutic doses stimulate respiration
@toxic doses depresses respiration and displaces bicarb (true metabolic acidosis)
-Don't use in 3rd trimester of pregnancy |
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Term
|
Definition
-Not a good anti-inflammatory
Good use for pts with: ulcers, blood thinners, clottind disorders, gout
**OD can cause fatal hepatic necrosis |
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Term
|
Definition
| Tx for overdose of Acetaminophen |
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Term
|
Definition
COX2 inhibitor (selective so it doesn't mess with homestatic properties of COX1)
Contra: Sulfa sensitivity
Sfx: Increase cardiovascular risk |
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Term
|
Definition
Tx: Severe rheumatoid arthritis unresponsive to conventional treatment
-antineoplastic drugs |
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Term
|
Definition
NSAID
-High anti-inflammatory
-high toxicity |
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Term
|
Definition
Tx: Severe rheumatoid arthritis unresponsive to conventional treatment
-Suppresses immunesystem |
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Term
|
Definition
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Term
|
Definition
Anti-Rheumatic
Binds TNFa (false receptor) and prevents it from interacting w/ receptors
Sfx: Infection, contraindicated in sepsis |
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Term
|
Definition
Anti-rheumatic
ab to TNFa
*Can cause lupus-like syndrome |
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Term
|
Definition
Anti-rheumatic
-Fusion protein that binds CD4 rendering T-cells inactive |
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Term
|
Definition
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|
Term
|
Definition
Anti-Gout (useful in relief of attacks)
-Blocks migration of granulocytes to area
-Not uricosuric |
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|
Term
|
Definition
Anti-Gout
-Increase excretion by decreasing reabsorption (have to drink a lot of water) |
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|
Term
|
Definition
Anti-Gout
-Increase excretion by decreasing reabsorption (have to drink a lot of water) |
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|
Term
|
Definition
Anti-gout
Inhibits xanthine oxidase (reduces production of uric acid) |
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