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Infectious Disease EXAM 4 - HIV Drugs
Infectious Disease EXAM 4 - HIV Drugs
11
Pharmacology
Graduate
02/14/2011

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Cards

Term
GI
metabolic
Definition
ADRs of Lamivudine and Emtricitabine (NRTIs)
Term
hypersensitivity reaction
have to test patient for HLA-B 5701 to see if they are at an increased risk of the hypersensitivity reaction
Definition
ADR of Abacavir (NRTI)
Term
Myelosuppression - seen as neutropenia from CBC
Definition
ADR of Zidovudine (NRTI)
Term
pancreatitis
peripheral neuropathy
Definition
ADR of Didanosine and Stavudine (NRTIs)
Term
nephrotoxicity
Definition
ADR of Tenofovir (NRTI)
Term

hepatic metabolism

hepatic dosing adjustment unknown

CYP3A4 DRUG INTERACTIONS

no renal dosing

class side effect: rash

Definition
common ADRs of NNRTIs (nevirapine, delavirdine, efavirenz, etravirine)
Term
pregnancy category D
neuropsychiatric effects
Definition
ADRs of Efavirenz (NNRTI)
Term
women CD4 count < 250
men CD4 count < 400
Definition
ADRs of Nevirapine (NNRTI)
Term
hepatic metabolism
no renal dosing, except atazanavir in HD
notorious for CYP3A4 DRUG INTERACTIONS
GI ADRs common, most require administration with food (except indinavir which is administered on an empty stomach)
rash: common with darunavir and tipranavir (sulfonamide moieties), amprenavir, fosamprenavir
hyperglycemia
fat maldistribution
possible increased bleeding episodes in patients with hemophilia
diarrhea: common with fosamprenavir, lopinavir/ritonavir, nelfinavir, tipranavir
increased liver enzymes: common with tiprinavir
increased cholesterol and TGs: common with ritonavir
Definition
common ADRs of PIs
Term
injection site reaction
Definition
ADRs of Enfuvirtide (fusion inhibitor)
Term
CYP450 drug interactions
Definition
ADR of Maraviroc (entry inhibitor)
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