Term
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Definition
Caused by organisms that are part of the normal microbial flora of the body
(Streptococcus and Enterococcus) |
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Term
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Definition
- Caused by pathogens that come into the body from the outside
(C. difficile & helicobacter pylori)
- Brought in through contaminated water and food.
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Term
Clinical Symptoms of Gastrointestinal Symptoms |
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Definition
Fever, vomiting, abdominal pain and diarrhea |
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Term
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Definition
- Most common
- Develops rapidly
- Accompanied by vomiting, gever and abdominal pain
- Caused by enterotoxin-secreting bacteria (Vibrio cholerae)
- Lasts 1 to 3 days
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Term
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Definition
- Rapid onset
- Smaller in volume
- contain blood and pus
- Accompanied by cramps and abdominal pain but very little vomiting
- Center in the colon
- Not as much fluid loss
- Lasts longer about 3-7 days
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Term
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Definition
- Systemic infection
- Prominent Feature: fever and abdominal pain
- Diarrhea is mild
- Penetrations of enterocytes spread to the bile tract and liver
- Most common: Typhoid fever (Salmonella enterica serotype typhi)
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Term
Dental and Periodontal Infections |
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Definition
- Most common: cavities and gingivitis
- Major source of problem: plaque
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Term
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Definition
- Occur sporadically
- Most commonly caused by Campylobacter, Salmonella, and Shigella
- Most commonly seen in children
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Term
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Definition
- Involve regional, national, and international populations
- Most common: cholera, typhoid fever and shigellosis
- Cholera and Typhoid fever are associated with contamination of water
- Shigellosis is associated with wars, crowding and poor sanitation
- In U.S. most frequent are E.Coli O157:H7, Cryptosporidium, and Giardia
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Term
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Definition
- Caused by enterotoxigenic strains of E. coli (50%)
- Caused by Shigella (20%)
- Major source of transmission: improperly cooked food
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Term
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Definition
- Intoxication: a toxin produced by a pathogen is involved
- Infection: pathogen is directly involved in the process
- Incubation time is shorter in intoxication than in infection
- Intoxication may involve organs outside the digestive tract
- Caused by failure to cook food adequately
- Salmonella, Clostridium perfringens and Staphylococcus aureus
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Term
Nosocomial Gastrointestinal Infections |
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Definition
- Traced to ill employee or contaminated food
- Caused by C. difficile and E. coli
- Symptoms include mild diarrhea
- C. difficile may be part of the patient's normal flora or from other patients
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Term
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Definition
- Soft dental deposit that forms because of bacterial colonization of the surface of the teeth
- Insoluble in aqeous media
- Resists removal by brushing and flossing
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Term
Formation of Dental Plaque |
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Definition
- Adhesion of bacteria to the pellicle is followed by growth of bacteria
- New layers of organisms pile on to the growing plaque
- Biofilm because it contains channels that transport nutrients to the bacteria
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Term
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Definition
- Saliva protects against the establishment of many bacteria
- Caused by organisms that produce acid by-products
- Most common: streptococcus mutans, streptococcus salivarius, Lactobacillus, Acidophils and Actinomyces species
- Bacteria absorb and metabolize sugars producing acid by-products causing tooth decay
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Term
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Definition
- Inflammatory condition of the gums
- Can be corrected
- Causes a loss of collagen
- Continues as long as dental plaque remains on a tooth
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Term
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Definition
- Infection of the gums that result in the loss of supportive bone and ligaments
- Bacteria can invade the tissue
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Term
Necrotizing Periodontal Disease |
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Definition
- Destruction of the mouth's soft tissue as well as the bone and ligaments
- Associated with emotional stress and poor oral hygiene
- Causes rapid ulceration of the tissues and pronounced bone loss
- Systemic and topical administration of antibiotics relieve the symptoms
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Term
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Definition
- Gram-negative rod shaped bacteria
- Facultative anaerobes
- Damage the intestines
- Do not form spores
- 3 serotypes (O, K and H antigens)
- O antigen: LPS
- K antigen: Capsule
- H antigen: flagellum
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Term
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Definition
- Gram-negative rods
- Lactose fermenting
- Have fimbraie and pili
- Produce toxins
- Pore-forming toxin: destroys the integrity of the cell
- Shiga toxin: blocks protein synthesis and causes death of the cell
- Heat-labile toxin: accumulation of water and other lipids in the lumen of the intestine
- Heat-stable toxin: secretion of liquids and electrolytes into the lumen of the intestine
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Term
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Definition
- Release a toxin
- Leading cause of mental retardation and malnutrition in underdeveloped countries
- Transmitted through consumption of food or water that is contaminated
- Adheres to the cells of the intestines
- Genes are found on plasmids
- Toxin causes water and electrolytes to flow into the intestine
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Term
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Definition
- Transmisison is fecal-oral
- Infants are the reservoir
- Use fimbriae to form colonies on intestinal cells
- Secretes five proteins into the cell's cytoplasm
- Proteins inhibit cell signaling
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Term
Enterohemorrhagic E. coli |
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Definition
- Produce shiga toxin
- Transmission: animals colonized with the pathogens
- Mostly caused by undercooked meat
- Attack the colon
- Mild: no treatment required
- Severe: liquid replacement required
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Term
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Definition
- Don't ferment lactose
- Lack flagella
- Produce the shiga toxin
- Causes dysentery
- Transmission: fecal-oral route, person to person or consumption of contaminated food or water
- Most severe: bacillary dysentery
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Term
Pathogenesis of Shigellosis |
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Definition
- Trigger an intense acute inflammatory response of the colon
- Kill the M cells of the colon and phagocytes
- Use an actin tail for transport
- Symptoms: fever, malaise and anorexia
- Treatment: antibiotics
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Term
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Definition
- Multiple Pilli
- Gastroenteritis: nausea and vomiting followed by cramps and diarrhea
- Bacteremia: leads to septic shock and death
- Enteric Fever: fever and headache followed by constipation or diarrhea
- Chronic Infection: Bacteria enter the blood leading to myocarditis or infection of distal sites of the body
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Term
Salmonella Gastroenteritis |
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Definition
- Results from improper food handling (Poultry)
- Transmission from animal or human reservoirs
- Bacteria are engulfed by Mcells and enter the lamina propria initiating a powerful inflammatory response
- Can induce apoptosis in the cell
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Term
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Definition
- Inhibit the release of the oxidative poisons used by macrophages to kill invading bacteria
- Hemorrhaging causes perforation of the wall of the colon or at the Peyer's patches
- Treatment: replacement of fluids and control of nausea and vomiting
- Vaccine available
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Term
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Definition
- Gram-negative, non spore-forming rod shaped bacteria
- Found in salt water
- Facultative anaerobes
- Toxin causes a intestinal infection
- Spread by contaminated water and poor sanitation
- Results in dehydration, hypokalemia and metabolic acidosis
- Balancing liquid and electrolyte loss
- Treatment: Tetracycline
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Term
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Definition
- Most common cause of diarrhea
- Primary reservoir: animals
- Transmission: ingestion of contaminated food or by direct contact with pets
- Most common source: undercooked poultry
- Produce a cytotoxin that arrests cell division
- Lasts 3-5 days
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Term
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Definition
- Gram-negative rod shaped with flagella
- Urease enzyme: allows it to survive acidic environments
- Vacuolating cytotoxin: causes apoptosis in infected cells
- Transmission: person to person through fecal-oral route
- Most common cause of gastritis
- Symptoms: nausea and upper abdominal pain
- Treatment: antimicrobial agents
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Term
Viral Infections of the Digestive System |
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Definition
- Rapid onset diarrhea
- Characteristics: brief incubation periods, fecal-oral routes of transmission and vomiting
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Term
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Definition
- non-enveloped, double-stranded RNA virus
- Common in infants and children
- Causes a decreased absorptive surface and decreased enzymatic function
- Vomiting, fever and diarrhea
- Complication: dehydration
- Severe cases require replacement of fluid and electrolytes
- Vaccine available
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Term
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Definition
- Persistant to acidic environments
- Seasonal infection patterns and predisposed to temperate climates
- Fecal-oral transmission
- Virus is brought into the host cell and viral RNA is released into the cytoplasm
- No treatment
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Term
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Definition
- Transmission: fecal-oral route
- Commonly caused by crowding and poor hygiene
- Onset of fever, anorexia, nausea, upper abdominal pain and jaundice
- Seen more in children
- No treatment just rest and adequate nutrition
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Term
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Definition
- Chronic carriers are the main reservoir
- Transmission: close contact with body liquids
- Onset of fatigue, loss of appetitie, nausea, and upper abdominal pain
- Can lead to cirrhosis, liver failure, or hepatocellular carcinoma
- Vaccine available
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Term
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Definition
- Transmission: blood transfusions and sex
- Most of those infected become carriers of the infection and progress to chronic hepatitis
- Leading cause of liver transplants
- Therapy with interferon-alpha and ribavirin
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Term
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Definition
- requires the presence of Heaptitis B
- Often seen in intravenous drug abusers
- Co-infection with Hepatitis B or superinfection of people already infected with Hepatitis B
- Cause a relapse, reoccurence of jaundice and increased risk of cirrhosis
- Treatment: interferon-alpha
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Term
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Definition
- Transmitted by the fecal-oral route
- Resembles Hepatitis A
- Causes disease in only pregnant women
- Associated with contaminated drinking water
- No treatment
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Term
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Definition
- Similar to Hepatitis C
- No treatment
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Term
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Definition
- Can survive in cold water for months and is resisitant to chlorine
- Transmission: fecal-oral route
- Found in fish, amphibians, reptiles, brids and mammals
- Contaminated water or food
- Diarrhea, abdominal cramping, nausea and fever
- Lead to significant weight loss and malnutrition
- 4 drugs available
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Term
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Definition
- infects the intestinal tract of both humans and other animals
- Domestic animals are the reservoir
- Person-to-person transmission
- Transmission: fecal-oral route, contamination of food and water
- Watery diarrhea
- No treatment needed
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Term
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Definition
- Significant mucosal damage, blood loss and anemia in children
- Asymptomatic infections: no need for treatment
- Severe disease: mebendazole
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