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Infections of CNS
Answer the qts! DO IT!
37
Microbiology
Undergraduate 2
09/30/2015

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Cards

Term
This refers to inflammation of the brain
Definition
Encephalitis
Term
There are no fenestrations on the endothelium here
Definition
Blood brain barrier
Term
There is a thick basement membrane here
Definition
Blood brain barrier
Term
There are astrocyte "feet" surrounding the capillary her
Definition
Blood brain barrier
Term
The endothelium here is fenestrated
Definition
Blood-CSF barrier
Term
There is a thin basement membrane here
Definition
Blood-CSF barrier
Term
There is a tight junction between the choroid plexus and epithelium here
Definition
Blood-CSF barrier
Term
This refers to inflammation of the membranes surrounding the brain and spinal cords
Definition
Meningitis
Term
This virus can be present in skin and mucosal lesions, move along peripheral nerves, and invade dorsal root ganglia alongside the vertebral column
Definition
Herpes simplex (HSV)
Term
This virus can infect muscle tissues, enter peripheral nerves, travel to the CNS, and multiply in neurones and glial cells
Definition
Rabies
Term
The normal CSF:plasma ratio of glucose
Definition
0.6
Term
High lymphocytes, high monocytes, moderately high protein, and normal glucose levels would be seen in this
Definition
'Aseptic" meningitis - usually viral
Term
Very high neutrophils, low glucose, high protein, cloudy CSF, and bacteria that can usually be cultured would be seen in this
Definition
'Pyogenic' - bacterial invasion
Term
The immune response to which of these is more rapid and inflammatory - bacterial or viral
Definition
Bacterial
Term
The name of special macrophages in the brain
Definition
Microglia
Term
Large numbers of immune cells squeezing through blood vessels from CSF into the brain can cause this fault in the barriers of the CNS
Definition
Capillaries become leaky
Term
The most common cause of bacterial meningitis
Definition
Neisseria meningitidis
Term
Most common clinical presentation of acute bacterial meningitis
Definition
Headache
Term
Fever, stiff neck, altered mental state, headache, and rash are all clinical presentations of what?
Definition
Acute bacterial meningitis
Term
A rash is seen in this percentage of people with acute bacterial meningitis
Definition
25%
Term
Examination of this is the gold standard of diagnosis of bacterial meningitis
Definition
CSF
Term
Is neisseria menigitidis gram negative or gram positive
Definition
Gram negative
Term
How neisseria menigitidis attacks the host
Definition
Express lipopolysaccharide or endotoxin
Term
These people are most susceptible to neisseria menigitidis infection
Definition
Kids under 3 months and adolescents
Term
Is there a vaccine for the serogroup B of neisseria menigitidis, the most common form in Aus?
Definition
No
Term
How you treat neisseria menigitidis
Definition
Intravenous benzylpenicillin or if allergic 3rd generation cephalosporin
Term
Would you give dexamethosone or rifampicin to someone (people over 2 months old) with a neisseria menigitidis infection
Definition
Yes
Term
The second most common cause of bacterial meningitis
Definition
Streptococcus pneumoniae
Term
Is streptococcus pneumoniae gram negative or positive
Definition
Gram positive
Term
The most common cause of bacterial meningitis in adults with a 20-60% mortality rate
Definition
Streptococcus pneumoniae
Term
When Streptococcus pneumoniae is identified, you treat with this for 10 days
Definition
Benzylpenicillin
Term
Why you would give dexamethosone to people over 2 months old with bacterial meningitis
Definition
Reduce inflammation
Term
It is least likely that this is the cause of bacterial meningitis
Definition
Mycobacterium tuberculosis
Term
Treatment with isoniazid, rifampin, pyrazinamide, and streptomycin or ethambutol for this cause of bacterial meningitis
Definition
Mycobacterium tuberculosis
Term
Is there a vaccination to prevent mycobacterium tuberculosis infection?
Definition
Yes
Term
Is haemophilus influenzae gram negative or positive
Definition
Gram negative
Term
Most healthy people carry non-capsular strains of this potential cause of menigitis in the throat
Definition
Haemophilus influenzae
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