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Infections of CNS
Infections of CNS
31
Real Estate & Planning
Pre-School
04/26/2009

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Term
inflammation of meninges
photophobia, headache, neck regidity
increased # of WBC in CSF (pleocytosis)
Definition
Meningitis
Term
Factor si C3b
URT
Binds to lungs and goes to CSF
meningitis from 1 mo to 18 y.o.
Definition
Meningitis from Strep. Pneumoniae
Term
most common meningitis
less than 1 m.o.
Definition
Meningitis from Group B strep.
Term
Brudenski sign
Definition
flex head forward, knees flex forward
Term
Kernig sign
Definition
flex hip, extend knee, pain
Term
Diagnosis of Meningitis
if neuroimaging negative get...
Definition
LP
gram stain and culture CSF
cell count and protein
Term
Gram neg. diplococci
nasopharynx
Epidemic cases: serotypes A,C
Sporadic cases: serotypes B,C,Y
Close contact, military/freshmen/endemic areas
Vaccine Quadravalent
Definition
Neisseria Meningitidis
Term
Meningitis Treatment
less than 1 month
Definition
Ampicillin + _____
Term
Meningitis Treatment
1 mo to 23 mo
Definition
Vancomycin + 3rd gen. ceph
Term
Meningitis Treatment
2 y to 50 yr
Definition
Vanco + 3rd gen. ceph
Term
Meningitis Treatment
50 yr +
Definition
Vanc. + ampicillin + 3rd gen. ceph
Term

Meningitis Treatment

penetrating trauma

postneurosurgery

CSF shunt

Definition
Vanc + cefepime
Term
Meningitis Treatment
Basilar skull fracture
Definition
vanc + 3rd gen. ceph.
Term
pleocytosis mild to moderate, mononuclear
inc. protein
glucose normal
granulomas
ziehl-neelson staining
culture standard for diag.
Definition
Chronic Bacterial Mengoencephalitis
Tuberculosis
Term

lymphocytes in CSF brain invasion mental deteroiration and mood deviation

 Tabes dorsalis - dorasl root and ganglia severe proprioceptiove loss dorsal columns are pale and atrophic

Definition
Chronic Bacterial Mengoencephalitis Neurosyphillis
Term
spirochete Borrelia burgdorferi
ticks spread
meningitis, facial nerve palsies
polyneuropathy
Definition
Chronic Bacterial Mengoencephalitis
neuroborreliosis
lyme disease
Term
General Term
fever, headache
altered level of consciousness
focal or diffuse neurological signs
Definition
Encephalitis
Term
Viral Encephalitits spp.
Definition
Flaviviridae
Toga
Bunya (not many cases)
Herpes (lots of cases)
number of others
Term
53yo female,
seizing, personality change, works in daycare
CSF: 400 wbc, 200rbc, lymphocytes predominate,
glu normal
protein elevated
gram stain neg.
Definition
Herpes simplex encephalities
HSV 1 adults
HSV 2 kids
Term
Enceph. Treatment
Definition
supportive, symptomatic, treat cause
Herpes: acyclovir
CMV ganciclovir/foscarnet
HIV: HAART
Term
Brain Abcess
Definition
Collection of puss
Term
Brain Abcess
Localizers
Temporal Lobe
Definition
Temporal Lobe
headache/aphasia
Term
Brain Abcess
Localizers
Frontal Lobe
Definition
Frontal Lobe
Mental Stauts change/hemiparesis, expressive speech disturbance
Term
Brain Abcess
Localizers
Cerebellum
Definition
Vomiting
Ataxia
nystagums
dysmetria
Term
Brain Abcess
Localizers
Brainstem
Definition
vomiting
hemiparesis
dysphagia
facial weakness
Term
Middle Cerebral Artery Distribution
Area of involvement
Definition
Endocardidits (heart valve)
Term
Brain Abcess
Diag.
Definition
image
LP
culture
surgical drainage
brain biopsy - do earlier in treatment if suspect toxoplasmosis
Term
10d of head and neck pain
returned from two week in jamaica
eosinophilia in blood
intracranial pressure (sign of enceph)
CSF: WBC 333
Definition
angiostrongylus cantonensis
rat lung worm
Term
angiostrongylus cantonensis
characteristics
Definition
rat lung worm
most common infection with eosinophilic meningitis
parasite - 3rd larva stage infects
most self limited
SE Asia/Sporadic US.
Term
pus between arachnoid and inner surface of dura
infection of sinuses or skull
Caused by strep or staph
Definition
Subdural Empyema
Term
associated with osteomyelitis may occur in SC diag. by aspiration by interventional radiology or surgery strep or Staph
Definition
Extradural Abcess
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