Term
What is the most used Quinolone antimicrobial?
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Definition
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Term
| Give the MOA for quinolones |
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Definition
| Inhibit supercoiling in bacterial DNA synthesis by binding to topoisomerases (DNA gyrase and topoisomerase IV) |
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Term
| Describe the bioavalability of quinolones |
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Definition
| High bioavailability w/ oral therapy |
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Term
| Ciprofloxacin is a ___ with activity against ___ |
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Definition
A Quinolone
against Pseudomonas |
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Term
| Levofloxacin is a ___ with activity against ___ |
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Definition
Quinolones
against Pseudomonas |
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Term
| Moxifloxacin is a ___ with activity against ___ |
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Definition
Quinolone
against Bacteroides fragilis (in mixed intra-abdominal infections) |
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Term
| Quinolones are generally effective against what type of bacteria? |
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Definition
aerobic Gram - bacteria
of urinary and GI tracts |
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Term
| What should be avoided to make sure quinolones are absorbed properly? |
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Definition
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Term
| Quinolones are ___ dependent |
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Definition
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Term
| Why Quinolones are contraindicated in pregnancy |
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Definition
| causes cartilage abnormalities |
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Term
| What the black box on quinolones pertains to |
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Definition
| Concomitant use of corticosteroids (especially in elderly) can cause tendonitis and tendon rupture |
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Term
| 2 Most common mechanisms of resistance to Quinolones |
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Definition
mutation of DNA gyrase
mutation of Topoisomerase IV |
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Term
| 3 Quinolones that can have an adverse effect of phototoxicity and why |
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Definition
| (assoc with halogen at position 8): Lomeflox, Sparflox, Clinaflox |
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