Term
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Definition
| It is the main drug used to treat Tb (kills mycoplasma tuberculosis) |
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Term
| Give the MOA for Isoniazid (Isonicotinic acid hydrazide (INH)) |
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Definition
| Inhibits synthetic pathways of the mycolic acid component of mycobacterial cell wall |
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Term
| What blocks absorption of Isoniazid (Isonicotinic acid hydrazide (INH))? |
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Definition
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Term
| 4 Adverse reactions to Isoniazid (Isonicotinic acid hydrazide (INH)) |
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Definition
Hepatitis (in first 3 months)
Peripheral Neuropathy
CNS symptoms (memory loss, seizures, etc.)
Dupuytren's contracture (fixed flexion of hand) |
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Term
| Name the second most commonly used drug to treat Tb |
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Definition
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Term
| What Pyrazinamide is used for |
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Definition
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Term
| When does Pyrazinamide work optimally? (3) |
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Definition
| When used in combination therapy (NOT with Rifampin), against semi-dormant Tb in acid pH |
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Term
| Pyrazinamide is a synthetic anolog of ___ |
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Definition
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Term
| Pyrazinamide (PZA) + Rifampin= |
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Definition
Possible Fatal liver toxicity
(for for treating Tb) |
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Term
| Pyrazinamide (PZA) is given for ___ months of the total ___ months of therapy for Tb. |
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Definition
Given for the first 2 months (in combination with other drugs, but NOT in pregnancy)
Total of 6 month drug therapy |
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Term
| 4 Drugs given for the first 2 months of therapy for Tb, and 2 that are given for the following 4 months |
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Definition
First Two Months:
– Isoniazid
– Rifampin
– Pyrazinamide
– Ethambutol (often discontinued if tests negative for resistance)
Next Four Months:
– Isoniazid
– Rifampin
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Term
What Ethambutol is used for
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Definition
| treats Tb (first 2 months) |
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Term
| Give the MOA for Ethambutol |
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Definition
| inhibits arabinosyl transferase and lipoarabinomanan synthesis in the cell wall of mycoplasma Tb |
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Term
| 3 interesting adverse reactions from Ethambutol |
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Definition
| Optic neuritis, impaired visual acquity, and impaired red-green color vision (slowly reversible) |
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Term
How to treat a pregnant woman with Tb (2 different options of drug regimens)
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Definition
INH(+pyridoxine) and rifampin for nine months
or
INH+pyridoxine or Rifampin (NOT pyrazinamide) with ethambutol for 18 months |
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