broad activity

bind to glucocorticoid receptor and change the transcription of many genes in the nucleus;alter production of IkB-alpha; IkB-alpha makes complex with NF-kB to keep it from getting to the nucleus- so, targets NF-kB txn factor

affects lymphocyte 1. proliferation, 2. activation, and 3. effector function

calcineurin inhibitors; bind to an intermediate protein called cyclophilin; prevents IL-2 and IL-6 release; complex targets NF-AT

calcineurin is a phosphatase that removes phosphate group from NF-AT (transcription factor) so it can go into the nucleus and activate t cell

binds to the FK binding protein (like tacrolimus) but doesn't affect calcineurin

blocks function of mTOR ( binds to mTOR)  and thus blocks G1-S phase of cell cycle

inhibits T cell proliferation in response to IL-2

blocks purine synthesis, and thus lymphocyte sine proliferation;

inosine monophospate dehydrogenase inhibitor