Term
|
Definition
|
|
Term
|
Definition
| mitral stenosis , diastolic murmur, head in l lateral decubitous position. |
|
|
Term
|
Definition
Binds to cyclophilins
complex inhibits calcineurin, prevent production of IL-2 and it's receptor
--> block in differentiation and activation of T-cells |
|
|
Term
Cylcosporine
Clinical Use |
|
Definition
post transplantation suppression of organ rejection
AND
selected autoimmune disorders |
|
|
Term
|
Definition
1) viral infections
2) lymphoma
3) nephrotoxic (preventable with mannitol diuresis) |
|
|
Term
Tacrolimus (FK506)
mechanism |
|
Definition
binds to FK-binding protein
inhibits secretion of IL-2 and other cytokines
similar to cyclosporine |
|
|
Term
Tacrolimus (FK506)
clinical use |
|
Definition
potent immunosuppresive for
organ transplant recipients |
|
|
Term
Tacrolimus (FK506)
toxicity |
|
Definition
Siginificant!
1) nephrotoxicity
2) peripheral neuropathy
3) HTN
4) pleural effusion
5) hyperglycemia |
|
|
Term
Sirolimus (rapamycin)
mechanism |
|
Definition
binds to mTOR
inhibits T-cell proliferation in response to IL-2 |
|
|
Term
Sirolimus (rapamycin)
clinical use |
|
Definition
Post-kidney transplant immunosuppression
used in combo with cyclosporine and corticosteroids |
|
|
Term
Sirolimus (rapamycin)
Toxicity |
|
Definition
1) Hyperlipidemia
2) thrombocytopenia
3) leukopenia |
|
|
Term
|
Definition
| monocolonal antibody with high affinity for the IL-2 receptor on activated T-cells |
|
|
Term
|
Definition
Antimetabolite precursor of 6-mercaptopurine
interferes with metabolism and synthesis of nucleic acids
toxic to proliferating lymphocytes |
|
|
Term
Azathioprine
Clinical Use |
|
Definition
1) kidney transplantation
2) autoimmune disorders (ie- glomerulonephritis and hemolytic anemia) |
|
|
Term
|
Definition
1) bone marrow suppression
2) active metabolite mecaptopurine is metabolized by xanthine oxidase; thus, toxic effects may be increased by allopurinol |
|
|
Term
muromonab-CD3 (OKT3)
Mechanism |
|
Definition
monoclonal antibody
binds to CD3 (epsilon chain) on the surface of T-cells
Blocks cellular interaction with CD3 protein responsible for T-cell signal transduction |
|
|
Term
muromonab-CD3 (OKT3)
Clinical use |
|
Definition
| 1) immunosuppression post-kidney transplant |
|
|
Term
Muromonab-CD3 (OKT3)
Toxicity |
|
Definition
1) cytokine release syndrome
2) hypersensitivity reaction |
|
|
Term
Aldesleukin (interleukin 2)
clinical use |
|
Definition
1) renal cell carcinoma
2) metastatic melanoma |
|
|
Term
Erythropoietin (epoetin)
clinical use |
|
Definition
| anemias (especially in renal failure) |
|
|
Term
Filgrastim (granulocyte colony-stimulating factor)
clinical use |
|
Definition
|
|
Term
Sargramostim (granulocyte-macrophage colony-stimulating factor)
clinical use |
|
Definition
|
|
Term
Alpha-interferon
clinical use |
|
Definition
1) hepatitis B and C
2) Kaposi's sarcoma
3) leukemias
4) malignant melanoma |
|
|
Term
Beta-interferon
Clinical use |
|
Definition
|
|
Term
gamma-interferon
clinical use |
|
Definition
| 1) chronic granulomatous disease |
|
|
Term
oprelvekin (interleukin-11)
clinical use |
|
Definition
|
|
Term
Thrombopoietin
clinical use |
|
Definition
|
|
Term
Muromonab-CD3 (OKT3)
Target |
|
Definition
|
|
Term
Muromonab-CD3 (OKT3)
Clinical use |
|
Definition
| prevent acute transplant rejection |
|
|
Term
|
Definition
|
|
Term
|
Definition
| prevent acute rejection of renal transplant |
|
|
Term
Digoxin Immune Fab
Target |
|
Definition
|
|
Term
Digoxin Immune Fab
clinical use |
|
Definition
| antidote for digoxin intoxication |
|
|
Term
|
Definition
|
|
Term
|
Definition
1) chron's disease
2) rheumatoid arthritis
3) psoriatic arthritis
4) ankylosing spondylitis |
|
|
Term
|
Definition
|
|
Term
|
Definition
1) chron's disease
2) rheumatoid arthritis
3) psoriatic arthritis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| prevent cardiac ischemia in unstable angina and in patients treated with percutaneous coronary intervention |
|
|
Term
Trastuzumab (herceptin)
target |
|
Definition
|
|
Term
Trastuzumab (herceptin)
clinical use |
|
Definition
| HER-2-overespressing breast cancer |
|
|
Term
|
Definition
|
|
