Term
| Corticosteroids immunosuppressant action |
|
Definition
-inhibit transcription of phospholipase A2 (so decr. arachidonic acid metabolites), leukocyte adhesion molc., cytokines IL-1, IL-2, IL-4
-also lympholytic action, induces T-cell apoptosis, cytotoxic (T>B cells, CD4+ > CD8+), inhibit NK activity |
|
|
Term
|
Definition
-first line of tx for auto-immune dz
-act as anti-inflam, immunosuppressants, and anti-cancer (dose dependent)
e.g. prednisolone, hydrocortisone, dexamethasone |
|
|
Term
|
Definition
A corticosteroid used in immunosupp. in autoimmune dz.
-good GCC selevtivity (i.e. minimal mineralocorticoid effects), half life 12-36hrs |
|
|
Term
|
Definition
A corticosteroid used in immunosupp. in autoimmune dz.
-not very good GCC selectivity (i.e. has mineralocorticoid effects), half life 8-12hrs |
|
|
Term
|
Definition
A corticosteroid used in immunosupp. in autoimmune dz.
-GCC selectivity (i.e. NO mineralocorticoid effects), potent, half life 36-72hrs - too long - therefore limited use |
|
|
Term
|
Definition
Immunosuppressants used in severe AI dz / if not responsive to GCC tx
e.g. azathioprine, cyclophosphamide |
|
|
Term
|
Definition
A cytotoxic immunosuppressant used in severe AI dz / if not responsive to GCC tx
-purine analogue so inhibits purine syn. and so DNA synt.
-used in e.g. pemphigus |
|
|
Term
|
Definition
Cytotoxic agent used as an immunosuppressant in severe AI dz / if not responsive to GCC tx
-also used in cancer therapy
-an alkylating agent - disrupts nucleic acid synthesis i.e. blocks DNA synthesis |
|
|
Term
|
Definition
An immunosuppressant - inhibits capacity of CD4+ Th-cells to synthesis and release IL-2
-so inhibits transformation of CD8+--> Tc-cells, and inhibits clonal prolif of CD4+
-used to suppress graft rejection, keratoconjunctivitis sicca in dogs |
|
|
Term
|
Definition
an immunosuppressant - decr. no of immunoglobulin Fc-R on macrophages
-synergises w. corticosteroids (almost never used alone) |
|
|
Term
|
Definition
| an anthelmintic used as an immunostimulant - stimulates the immune system |
|
|
