IL-1

Produced by APC's

stimulates Helper T cells

Pleiotropic

similar to TNFα

induces adhesion molecule expression

Produced by T_H1

stimulates T cell activation and proliferation

Pleiotropic

enhances cytotoxic activity of NK cells and CTL

Produced primarily by T Cells, also NK cells, and others

growth factor for hematopoetic cells

Produced by T_H2, & mast cells

Promotes proliferation and differentiation of B cells

Promotes T_H2 proliferation and mast cell growth

Ig class switch from IgG to IgE

produced by T_H2 cells

proinflammatory

aids in B cell development

Wound Healing

produced as a result of physiological stress

chemoattractant: attracts neutrophils and T cells (thus proinflammatory)

produced by T_H2 cells

something different: ANTI-INFLAMMATORY

T_H1

Produced by ALL CELLS 

antiviral effects

highly pleiotropic

induction of MHC class I molecules on

all somatic cells

Produced by T_H1 cells, CTL, amd NK cells

highly pleiotropic

produced by T_H2 cells and mast cells

Promotes IgG to IgE class switch

Produced by T_H1, macrophages, & mast cells

Highly pleiotropic

similar to IL-1 in activity (not structure)

involved in septic shock and chronic imflammatory diseases

produced by immune and non-immune cells

ANTI-INFLAMMATORY

Down regulates MHC II expression

pathology involving fibrosis