Term
| Ultimate precursor for lymphocyte? Ultimate precursor for innate immune cells? |
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Definition
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Term
| Two main components of lymphocyte development |
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Definition
antigen independent production of lymphocytes with varying specificities antigen dependent- clonal selection based on fit and then clonal expansion
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Term
| Sequence of B cell receptor/Ig gene rearrangement |
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Definition
heavy chain gene rearrangement make pre B cell receptors (made of heavy chain and surrogate light chains)
allelic exclusion after one chain successfully recombines light chain gene rearrangment leadin to transitional/naive B cells
enter lymphoid follicles exposed to antigen, leading to mature B cells and memory B cells
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Term
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Definition
| once one chain has successful recombination, the other chromosome is blocked from recombination |
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Term
| Three mechanisms of central tolerance |
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Definition
deletion anergy receptor editing
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Term
| Mechanism of deletion/negative selection of BCR |
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Definition
| BCR recognizes and crosslinks with multivalent self antigen with high affinity, leading to apoptosis |
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Term
Mechanism of anergic reaction of BCR |
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Definition
BCR reacts with monovalent self antigen with a low to moderate affinity, leading to its migration to the periphery |
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Term
| Mechanism of receptor editing of BCR |
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Definition
when the BCR react strongly with self, it can be stimulated to undergo additional gene rearrangement events to produce a new antigen receptor with new antigen specificity |
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Term
| Explain the phenomenon of isotype switching |
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Definition
| During clonal expansion, you can switch to a different Ig/BCR via somatic hypermutation. |
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Term
Mechanism of TCR development |
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Definition
start with a double negative cell antigen R rearrangement beta chain rearrangement to make a pre TCR (beta and pTalpha chain) alpha chain rearrangement
creat double positive cell (CD4, CD8) Three potential option death by neglect (lack of positive selection) negative selection positive selection
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Term
Once the beta chain of TCR has been created, what signals does it give out? |
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Definition
stops additional TCR beta chain rearrangement (allelic exclusion) stimulate proliferation stimulate expression of CD4 and CD8 (double positive cell) stimulate alpha chain rearrangment
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Term
| Advantage of rearragement of beta and alpha chain during T cell development |
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Definition
| efficient way of generating receptor diversity and junctional diversity |
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Term
| During what stage of life are gama delta T cells expressed |
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Definition
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Term
| Function of gamma delta T cells |
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Definition
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Term
| Mechanism of action of delta gamma T cell |
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Definition
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Term
| What cause positive selection in TCR? |
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Definition
| recognition of self/MHC peptide with LOW affinity |
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Term
Cause of negative selection of TCR |
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Definition
| recognition of MHC peptide with HIGH affintiy |
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Term
| Cause of death by neglect/lack of positive selection in TCR |
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Definition
NO interaction btw TCR and MHC |
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Term
| Explain what is ment by MHC restriction |
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Definition
| the means by which to ensure that TCR will recognize self MHC and self peptides on the MHC |
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Term
| Effect of Bare lymphocyte syndrome on TCR's |
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Definition
if we dont express MHC II, we will have no CD4 T cells, only CD8 T cells if we dont express MHC I, we will have no CD8 T cells, only CD4 cells
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Term
Cause of Autoimmune regulator deficiency (AIRE) |
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Definition
normally, autoimmune regulatore is a TF expresssed in thymic medulla epithelial cells that promote expression of proteins normally expressed in peripheral organs in the thymus this will lead to production of strong anti self TCR's
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