Term
Cyclosporine
1. Mechanism
2. Use
3. Toxicity |
|
Definition
1. Binds cyclophilins – Complex inhibits calcineurin – Blocks the differentiation and activation of T-cells – ? IL-2
2. Suppresses organ rejection, select autoimmune disorders
3. Viral infections, Lymphoma, Nephrotoxic (prevent with manitol dieresis) |
|
|
Term
Tacrolimus (FK506)
1. Mechanism
2. Use
3. Toxicity |
|
Definition
1. Mechanism
2. Use
3. Toxicity
1. Binds FK-binding protein – Complex inhibits calcineurin – Blocks the differentiation and activation of T-cells – ? IL-2
2. Suppresses organ rejection
3. Nephrotoxic, Peripheral Neuropathy, Hypertension, Pleural Effusion, Hyperglycemia |
|
|
Term
Azathioprine
1. Mechanism
2. Use
3. Toxicity |
|
Definition
1. Antimetabolite precursorof 6-mercaptopurine – Interferes with metabolism and synthesis of nucleic acids
2. Proliferating Lymphocytes, Kidney transplant, Autoimmune disorders (glomerulonephritis, hemolytic anemia)
3. Bone Marrow Suppression |
|
|
Term
Muromonab-CD3 (OKT3)
1. Mechanism
2. Use
3. Toxicity |
|
Definition
1.Monoclonal antibody to CD3 of T-cells – Blocks cellular interaction with CD3 – no T-cell signal transduction – Blocks Antigen recognition
2. Post-Kidney Transplant
3. Cytokine Release Syndrome, Hypersensitivity rxn. |
|
|
Term
Sirolimus (Rapamycin)
1. Mechanism
2. Use
3. Toxicity |
|
Definition
1. Binds to mTOR – Inhibits T-cell proliferation in response to IL-2
2. Post-Kidney Transplant in combo. w/ cyclosporine, corticosteroids
3. Hyperlipidemia, Thrombocytopenia, Leukopenia |
|
|
Term
Mycophenolate Mofetil
1. Mechanism
2. Use |
|
Definition
1. Inhibits de novo guanine synthesis – Blocks lymphocyte production
2. Immunosuppressant |
|
|
Term
Daclizumab
1. Mechanism
2. Use |
|
Definition
1. Monoclonal antibody to IL-2 receptor on T-cells
2. Immunosuppressant |
|
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