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not just defense against microorganisms not just defense most fundamental definition based on distinguishing self from non-self |
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Four classes of pathogens |
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1. bacteria (extracellular/intracellular) 2. viruses (intracellular) 3. parasites 4. fungi |
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is bounded specifically to toxins and neutralize them |
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developed during the lifetime of an individual lifeleong protective immunity slow to develop |
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nonspecific no long lasting immunity against specific immunity |
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Five types of white blood cells |
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Definition
neutrophils lymphocytes monocytes eosinophils basophils |
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four types of phagocytic cells |
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dendritic cells macrophages neutrophils eosinophils |
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antigen-presenting lymphatic tissue presents antigens to helper-t cells, initiating a primary immune response |
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functions in innate immunity by destroying microbes and in acquired immunity as an antigen presenting cell |
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most abundant white blood cell circulated in blood attracted by signals in infected tissue phagocytic tend to self destruct ass they destroy foreign invaders (short life span) |
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destroy parasitic organisms play major role in allergic reactions mucosal surfaces low phagocytic activit destructive enzymes |
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produces histamine and other molecules that trigger inflammation in response to infection and in allergic reactions |
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can kill tumor cells and virus infected cells ass part of innate immunity detection of ABNORMAL ARRAY OF SURFACE PROTEINS |
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mature in the bone marrow |
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migrate from the bone marrow and migrate to the thymus to mature |
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Definition
signaling molecule group of small proteins secreted by number of cells types that regulate the function of other cells |
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Cells that release cytokines |
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Definition
macrophages neutrophils helper t cells |
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Definition
proteins that provide innate defense by INTERFERING WITH VIRAL INFECTIONS |
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Interferon alpha and interferon beta |
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Definition
secreted by virus infected cells, help nearby cells resist viral infection |
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Definition
secreted by t-cells helps to activate macrophages |
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a protein secreted by plasma cells (differenetiated B cells) that binds to a particular antigen ANTIGEN IS ANOTHER WORD FOR IMMUNOGLOBULIN |
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Major histocompatibility complex molecule (MHC) |
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Definition
host protein that functions in antigen presentation |
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any sustance that elicits a response from a b cell or a t cell |
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T cell's role in adaptive immunity |
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Definition
destroy infected cells to eradicate intracellular pathogens all viruses, some bacteria INTRACELLULAR |
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B cell's role in adaptive immunity |
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Definition
B cells secrete antibodies to attack extracellular pathogens most bacteria EXTRACELLLAR |
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T cell receptor (TCR) creation |
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Definition
V segment D segment J segment |
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