Term
| What isotypes are memory cells? |
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Definition
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Term
| How are B and T cells removed after infections? |
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Definition
-The B cell differentiation to plasma cells is antigen-dependant and once the antigen is removed, the plasma cells simply die off (only live for about 2 weeks)
-The T cell removal is more active and depends on AICD (activation-induced cell death) which is mediated through Fas pathway
-Basically, the T cells start expressing Fas as soon as they are activated and eventually a cell with a FasL will bind to them and induce apoptosis |
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Term
| Describe memory cell migration/cycling? |
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Definition
| -They home to tissues where they first encountered antigen due to specific expression of adhesion molecules (of which they have a higher amount) |
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Term
| Compair the level of adhesion molecules, level of IL-2 receptor, and size of naive vs. active vs. memory T cells? Which will have the highest affinity? |
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Definition
Naive;
-Low level of adhesion molecules
-Low level of IL-2 receptor
-Small size
Active;
-High level of adhesion molecules
-High level of IL-2 receptor
-Large size
Memory
-High level of adhesion molecules
-Low level of IL-2 receptor
-Small size
-The memory will have the highest affinity |
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Term
| What is the lag time for primary vs. secondary? |
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Definition
| -7-10 days and 1-3days (week or so vs. a few days) |
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Term
| What is the memory T cell marker (Lima)? |
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Definition
-CD 45RO.... think O for old (Not RH!)
-45's Really Old |
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