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Definition
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Definition
same species (identical twin) transplant |
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Definition
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different animal species transplant pig hear valves |
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Definition
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differemt place skin graft kidney |
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Definition
MHC I type A B C all nucleated cells important in acute reaction |
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Definition
MHC class II DR, DQ, ALL antigen presentation cells important for chronic rejection |
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Definition
done by pre formed antibodies xenographic/ABO |
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Term
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Definition
T and NK cells within days to weeks mismatched MHCs
direct pathway APC from the graft present graft antigen to self T cells. |
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Term
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Definition
T and NK cells within months to years direct presentation of minor antigens indirect presentation of antigens, |
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Term
2 categories of diseases for which treatment with hsc can be used |
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Definition
immine canceres
gneetic probelems |
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Term
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Definition
perfect genetic match no GVHD
cons: no GVL |
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Term
pros and cons of allogenic |
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Definition
pros gvl cure genetic desease
cons hard to find immune reactions |
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Term
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Definition
if the immunes systems don't ablate each other they can tolerate each other. |
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Term
whole bone marrow positives and negatives |
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Definition
+potential gvl -tumor -Graft versus host |
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Term
mobilized peripheral stem cells |
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Definition
pros much less invaseive than whole bone marrow much greater Graft versus leukemia than FACS
cons more GVHD than whole bone marrow |
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Term
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Definition
no chance of GVHD
no graft vs lymphoma
no chance of tumor recurrance
COns: no Graftt versys leukemia |
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Term
minor histocompatibility antigen |
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Definition
not HLA A/O very polymorphic cause rejection |
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Term
graft versus host disease |
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Definition
donor lymphocytes recognize both MHC and MiHC as foreign and mounts an immune response against host (“donor eliminates host”). Symptoms include rash, hepatic veno-occlusive disease, GI, and renal dz. Allogeneic BMT is most common cause. Occurs with HSC or BM transplants. |
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Definition
Acute: occurs in first 100 days following transplant, neutrophil engraftment mediated |
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Definition
occurs after 100 days following transplant. Mediated more by auto-antibodies, affects same organs as acute GVHD. |
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Definition
Pro: can be used to eliminate host cancer (graft vs leukemia: GVL); Con: increased chance of graft rejection/immune response |
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Term
Common GVHD anatomical sites |
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Definition
Skin (rash), liver (VOD-acute, hepatitis-chronic), GI tract (diarrhea) |
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Term
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Definition
1. HLA mismatch 2. Older age (donor or host) 3. Gender mismatch 4. type of underlying disease 5. intensity of transplant conditioning regimen 6. levels of immunosuppressant |
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Term
HLA-matched sibling bone marrow has a higher probability of engraftment than that from HLA-matched, unrelated donors. What might be responsible for this difference? |
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Definition
MiHA. The probability of engraftment depends on the degree of matching for HLA loci and non-HLA loci (MiHA). HLA-matched unrelated donors have minor antigen mismatchs. |
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