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Immunology Problem Set 7
problem set 7
26
Medical
Professional
03/08/2009

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Term
autograft
Definition
self transplant
Term
syngeneic graft
Definition
same species (identical twin) transplant
Term
allogenic graft
Definition
different person
Term
xenogeneic
Definition
different animal species transplant
pig hear valves
Term
orthotpic
Definition
in the same same space
Term
heterotopic graft
Definition
differemt place
skin graft
kidney
Term
HLA class I
Definition
MHC I type A B C all nucleated cells important in acute reaction
Term
HLA Class II
Definition
MHC class II DR, DQ,
ALL antigen presentation cells
important for chronic rejection
Term
hyperacute rejection
Definition
done by pre formed antibodies
xenographic/ABO
Term
acute hypersensitivity
Definition
T and NK cells
within days to weeks
mismatched MHCs

direct pathway
APC from the graft present graft antigen to self T cells.
Term
chronic rejection
Definition
T and NK cells
within months to years
direct presentation of minor antigens
indirect presentation of antigens,
Term
2 categories of diseases for which treatment with hsc can be used
Definition
immine canceres

gneetic probelems
Term
pros/cons of autologous
Definition
perfect genetic match
no GVHD

cons:
no GVL
Term
pros and cons of allogenic
Definition
pros
gvl
cure genetic desease

cons
hard to find
immune reactions
Term
heamtopymphoid chimnera
Definition
if the immunes systems don't ablate each other they can tolerate each other.
Term
whole bone marrow positives and negatives
Definition
+potential gvl
-tumor
-Graft versus host
Term
mobilized peripheral stem cells
Definition
pros much less invaseive than whole bone marrow
much greater Graft versus leukemia than FACS

cons more GVHD than whole bone marrow
Term
FACS purified
Definition
no chance of GVHD

no graft vs lymphoma

no chance of tumor recurrance

COns:
no Graftt versys leukemia
Term
minor histocompatibility antigen
Definition
not HLA A/O
very polymorphic
cause rejection
Term
graft versus host disease
Definition
donor lymphocytes recognize both MHC and MiHC as foreign and mounts
an immune response against host (“donor eliminates host”). Symptoms include rash,
hepatic veno-occlusive disease, GI, and renal dz. Allogeneic BMT is most common
cause. Occurs with HSC or BM transplants.
Term
acute GVHD
Definition
Acute: occurs in first 100 days following transplant, neutrophil engraftment mediated
Term
chronic GVHD
Definition
occurs after 100 days following transplant. Mediated more by auto-antibodies,
affects same organs as acute GVHD.
Term
pros and cons of GVHD
Definition
Pro: can be used to eliminate host cancer (graft vs leukemia: GVL); Con:
increased chance of graft rejection/immune response
Term
Common GVHD anatomical sites
Definition
Skin (rash), liver (VOD-acute, hepatitis-chronic), GI tract (diarrhea)
Term
risk factors for GVHD
Definition
1. HLA mismatch
2. Older age (donor or host)
3. Gender mismatch
4. type of underlying disease
5. intensity of transplant conditioning
regimen
6. levels of immunosuppressant
Term
HLA-matched sibling bone marrow has a higher probability of engraftment than
that from HLA-matched, unrelated donors. What might be responsible for this
difference?
Definition
MiHA. The probability of engraftment depends on the degree of matching for HLA loci
and non-HLA loci (MiHA). HLA-matched unrelated donors have minor antigen
mismatchs.
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