Term
| Explain the 4 life phases of a B cell |
|
Definition
B cells are generated in the bone marrow
elimate self reactive b cells in bone marrow
activation of B cells by foreign antigen in secondary lymphoid tissue
differentiation to antibody secreting plasma cells and memory cells in secondary lymphoid tissues. |
|
|
Term
| stem cell heavy and light chains |
|
Definition
|
|
Term
|
Definition
heavy chain light chain
early pro b dj germ
late pro b VDJ germ
large pre b VDJ delta 5 v pre B
this temporay light chain helps with allelic exclusion, proliferation, initiates light chain and K/D
small pre b VDJ germ
immature pre b IgM tryout
mature naive b |
|
|
Term
| Which poriton of the antibody determines the Ig isotype? |
|
Definition
|
|
Term
| directly binds the antigen |
|
Definition
|
|
Term
| bound by the effector cell receptor |
|
Definition
|
|
Term
| Contains complementarity determining region |
|
Definition
|
|
Term
| contains disulfide bridges |
|
Definition
|
|
Term
|
Definition
| determines effector function |
|
|
Term
|
Definition
| different type of Fc regiond etermines the type of immunoglobulin you have. the heavy chain sets the type |
|
|
Term
|
Definition
| part of the antigen that is bound by the Ig |
|
|
Term
|
Definition
| Part of the antibody that binds the antigen |
|
|
Term
|
Definition
| B cell signaling receptor |
|
|
Term
|
Definition
|
|
Term
| B cells need survivial signals expressed by _______ |
|
Definition
| follicular dendritic cells. |
|
|
Term
| in order to home, b cells must express |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| the story of b cell activation |
|
Definition
1) naive b cell into t cell zone
2) b cell interacts with cd4 t cell and becomes activated and begins to proliferate
3) a subset of activated b cels migrates to gernmi cal centers in the the cortex draggin their cd 4 cell with them.
4) class switch remobine
5) fds pay attention to some in the germinal center-promote survival
6) plasma and memory cells exit the germical center. |
|
|
Term
|
Definition
multimeric 5 er bounded by J chain
very good at fixing complemenmt
low afinity |
|
|
Term
|
Definition
non multimeric brambell receptor crosses the placenta.
most b cells class switch to IgG. long term memory
monomeric
leaks out _> brambell receptor brins back
vasolateral transport process long half lip placenta crosses |
|
|
Term
|
Definition
not multimeric structurally same as IgG
foudn in serum
allergic response |
|
|
Term
|
Definition
mucosal sufraces
mucosal immunity
poly IgA receptor blood to mucous
foudn in blood |
|
|
