Term
| mechanism of innate immunity |
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Definition
consitutively active
complement system
physical
low specificity |
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Term
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Definition
high specificity
must be activated |
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Term
| response time frame for adpative and innate immunity |
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Definition
adaptive immunity-slow
innate immunity-quick |
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Term
| cellular effectors in innate immunity |
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Definition
toll like receptors
macrophages
NK cells
monocytes
neutrophils |
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Term
| cellular effectors of adaptive immunity |
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Definition
T cells and B cells
follicular dendritic antigen presenting cells |
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Term
| surface receptor molecules for innate and for adaptive |
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Definition
for innate: TLR
nuclear cell receptor
inflamasome
surface receptor T cell
B cell receptors
MHC I and II |
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Term
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Definition
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Term
| adaptive protects against |
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Definition
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Term
| example of innate immunity |
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Definition
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Term
| example of adaptive immunity |
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Definition
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Term
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Definition
| a variety of different t cells makes multiplications of itself |
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Term
|
Definition
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Term
|
Definition
lymph nodes
peyer's patches
tonsils
spleen
mucosal
MALT
GALT |
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Term
|
Definition
effector cells
MHC I
cause apoptosis
cytotoxic |
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Term
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Definition
co stimulate B cells
MHC II
secretes cytokines |
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Term
|
Definition
bacterial macrophages
helps B cells against intracellular parasites |
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Term
|
Definition
parasites Ige
eosinophils
extracellular parasites |
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Term
|
Definition
IL 17
automimmunity
bacteria
fungi |
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Term
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Definition
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Term
| Draw a T cell receptor and MHC I and II molecule |
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Definition
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Term
| each t cell close expresses 1 |
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Definition
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Term
| Each t cell recognize ______ type of antigen bound to MHC |
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Definition
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Term
| signal transduction to the intracellular domain |
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Definition
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Term
| steps in VDJ recombination |
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Definition
1) germline
2) somatic recombination rag 1/2 endonucleases cleave recombination signal sequence
3) generation of hair pins
4) release of haripins to create the P nucleotides
5) N nucleotides added via Terminal deoxynucleotideal transssssraae
6) pairing of strands
7) NHEL |
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Term
|
Definition
| complementary determining regions |
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Term
|
Definition
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Term
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Definition
| encoded junction of VDJspecificity of antigen comes from this complimentaritty determining region. |
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Term
|
Definition
by product of recombination
signal joiny t cell reeptor exxcision circles
useful for measuring the output of T cells by the Thymus |
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Term
|
Definition
failure of the recombination process of TCRs and Ig
results in arrested development of T cells and B cells. |
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Term
| what kind of t cells do you get in the subscapular space |
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Definition
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Term
| what kind of t cells do you get in the thymoc cortex |
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Definition
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Term
| what kind of t cells do you get into the thymic medulla |
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Definition
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Term
| double positive T cells have death by ________ |
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Definition
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Term
| When does a t cell graduate from the subscapular space? |
|
Definition
when it has acheived a sucesful b chain rearrangement
b chain succesfully expressed with a pre-T aplpha chain |
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Term
| When does a t cell graduate from the thymi cortex? |
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Definition
When it expresses CD4/CD8
undergoes interaction with MHC I or MHC II |
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Term
| What kind of sepection occurs in the thmyic cortex |
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Definition
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Term
| What kind of selection goes on in thymic medulla? |
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Definition
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Term
| order of t cell receptor rearrangmenet |
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Definition
b rearrangement stops
cell proliferates
CD4/CD8 induction
a rearrangement begins |
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