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Immunology Final
Cytokines and Antibodies
22
Veterinary Medicine
Graduate
11/18/2010

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Cards

Term
IL-6
Definition
Cytokine - Stimulates acute phase proteins, mediate innate immunity
Term
IL-1
Definition
Cytokine - Inflammatory, produced during gram- infection, mediate innate immunity
Term
TNF-a
Definition
Cytokine - Tumor Necrosis Factor - Inflammatory - primary mediator of gram- infection - Increases production of other inflammatory cytokines, activates adhesion molecules, causes tissue destruction.
Term
chemokines
Definition
Cytokine - chemotaxic for other molecules - tells them to come
Term
INF-γ
Definition
activates CD8 T cells, macrophages, NK cells
Term
IgM
Definition
opsonization and complement-aided lysis, Pentamer, 10 Ag binding sites. First Ab produced during response, Best at activating complement
Term
IgE
Definition
attacks helminths, activates degranulation of granulocytes (mast cells, basophils, eosinophils). Found in mucosa bound to receptors on Mast cells and basophils. Functions in allergic reactions. 2 Ag binding sites.
Term
IL-4
Definition
activates B-cells, regulate lymphocyte growth, activation
Term
IL-2
Definition
Primarily promotes CD8 T-cells, also stimulates NK cells, macrophages, Ig in B-cell. regulate lymphocyte growth, activation.
Term
IL-10
Definition
regulate lymphocyte growth, activation.
Term
IL-12
Definition
regulate lymphocyte growth, activation.
Term
IL-5
Definition
activates and recruits eosinophils
Term
TNF-b
Definition
Activates neutrophils and macrophages
Term
IL-3
Definition
Hematopoietic cytokine - stimulates myeloid/granulocyte precursors to become leukocytes
Term
GM-CSF
Definition
Hematopoietic cytokine - stimulates myeloid/granulocyte precursors to become leukocytes
Term
M-CSF
Definition
Hematopoietic cytokine - stimulates myeloid/granulocyte precursors to become monocytes
Term
G-CSF
Definition
Hematopoietic cytokine - stimulates myeloid/granulocyte precursors to become neutrophils
Term
Erythropoietin
Definition
Hematopoietic cytokine - stimulates myeloid/erythroid precursors to become RBCs
Term
IgG
Definition
Major class of Ig in serum, lymph, tissue spaces. Crosses placenta, main Ig found in ruminant Colostrum
Term
IgD
Definition
Mostly found on surface of B cells. No disulfide bonds.
Term
IgA
Definition
Mucosal surfaces and secretions. Dimeric most common form in animals , 4 Ag binding sites.
Term
Antibodies
Definition
My Dear Grandma Eats Apples (Igs and order on Constant Heavy Chain - isotype determinant)
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