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Immunology Cytokine Activity
Table 4.5
24
Immunology
Intermediate
09/25/2016

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Term
IL-1 Immune branch?
Definition
Innate Immunity
Term
IL-1 produced by? (4)
Definition
Monocytes, activated macrophages, fibroblasts, and dendritic cells
Term
IL-1 main function? (3)
Definition
Induces: acute phase response, production of various other cytokines and chemokines including IL-6, and upregulates adhesion molecules
Term
IL-6 Immune branch?
Definition
Innate Immunity
Term
IL-6 produced by? (2)
Definition
Activated macrophages and T cells
Term
IL-6 main function? (4)
Definition
Induces: acute phase response, fever, regulates antibody synthesis, and participates in B-cell and T-cell activation and differentiation
Term
TNF-alpha immune branch??
Definition
Innate Immunity
Term
TNF-alpha produced by? (4)
Definition
activated macrophages, activated T cells, NK cells, and Mast cells
Term
TNF-alpha main function? (3)
Definition
Modulates T-cell activation, expression of MHC class II molecules, and regulates development of T-regulatory cells
Term
IL-2 immune branch?
Definition
Adaptive immunity
Term
IL-2 produced by?
Definition
activated T cells
Term
IL-2 main function? (4)
Definition
Induces proliferation of newly activated T cells, NK cells, antibody production of B cells, and modulates development of I-regulatory cells]
Term
IL-4 immune branch?
Definition
adaptive immunity
Term
IL-4 produced by? (2)
Definition
TH2 cells and mast cells
Term
IL-4 main function? (3)
Definition
Induces B-cell activation, isotype switch to IgE, and suppression of TH1 cell functions, differentiation of TH0 cells into TH2 cells
Term
IL-5 immune branch?
Definition
Adaptive immunity
Term
IL-5 produced by? (2)
Definition
TH2 cells and mast cells
Term
IL-5 main function?? (2)
Definition
Promotes B cell differeentiation and increase antibody secretion, and modulates action of allergy-related cells such as eosinophils
Term
IL-10 immune branch?
Definition
adaptive immunity
Term
IL-10 produced by?
Definition
mononuclear cells
Term
IL-10 main function? (5)
Definition
Downregulates immune response, synthesis of cytokines such as IL-2, IL-3, TNF-alpha, and INF-gamma, expression of class II MHC molecules and various co-stimulatory molecules on antigen-presenting cells, and has anti-inflammatory effects
Term
INF-gamma immune branch?
Definition
Innate and adaptive immunity
Term
INF-gamma produced by? (3)
Definition
NK cells, cytotoxic T cells, and TH1 cells
Term
INF-gamma main functions? (4)
Definition
Increase antigen presentation, expression of both class I and class II MHC molecules, differentiation of TH1 cells activity of NK cells, and downregulates activity of TH2 cells
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