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Immunology 5 (Autoantibodies)
Immunology First Aid 2012
24
Medical
Professional
05/28/2013

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Cards

Term
What autoantibodies can be seen in SLE? (not drug induced), (3)
Definition

Antinuclear antibodies (ANA)

Anti-dsDNA

Anti-Smith

Term
What's the autoantibody seen in drug induced lupus?
Definition
Antihistone
Term
What's the autoantibody that can be seen in Rheumatoid arthritis?
Definition
Anti-IgG (rheumatoid factor)
Term
What's the autoantibody that can be seen in Scleroderma (CREST)?
Definition
Anticentromere
Term
What's the autoantibody that can be seen in Scleroderma (diffuse)?
Definition
Anti-Scl-70 (anti-DNA topoisomerase I)
Term
What's the autoantibody that can be seen in primary biliary cirrhosis?
Definition
Antimitochondrial
Term
What's the autoantibody that can be seen in Celiac disease?
Definition
Antigliadin, Antiendomysial
Term
What's the autoantibody that can be seen in Goodpasture's syndrome?
Definition
Anti-basement membrane
Term
What's the autoantibody that can be seen in Pemphigus vulgaris?
Definition
Anti-desmoglein
Term
What's the autoantibody that can be seen in Hashimoto's thyroiditis?
Definition
Antimicrosomal, Antithyroglobulin
Term
What's the autoantibody that can be seen in Polymyositis, Dermatomyositis?
Definition
Anti-Jo-1
Term
What's the autoantibody that can be seen in Sjogren's syndrome? (2)
Definition

Anti-SS-A (anti-Ro)

Anti-SS-B (anti-La)

Term
What's the autoantibody that can be seen in mixed connective tissue disease?
Definition
Anti-U1 RNP (ribonucleoprotein)
Term
What's the autoantibody that can be seen in autoimmune hepatitis?
Definition
Anti-smooth muscle
Term
What's the autoantibody that can be seen in Type 1 diabetes mellitus?
Definition
Anti-glutamate decarboxylase
Term
What's the autoantibody that can be seen in Wegener's granulomatosis?
Definition
c-ANCA
Term
The HLA subtype DR2 is associated with ___ (4)
Definition

Multiple sclerosis

Hay fever

SLE

Goodpasture's

Term
The HLA subtype DR3 is associated with ___
Definition
Diabetes mellitus type 1
Term
The HLA subtype DR4 is associated with ___
Definition

Rheumatoid arthritis

Diabetes mellitus type 1

Term
The HLA subtype DR5 is associated with ___
Definition

Pernicious anemia -> B12 deficiency

Hashimoto's thyroiditis

Term
The HLA subtype DR7 is associated with ___
Definition
Steroid-responsive nephrotic syndrome
Term
The HLA subtype A3 is associated with ___
Definition
Hemochromatosis
Term
The HLA subtype B27 is associated with ___
Definition

Psoriasis

Ankylosing spondylitis

IBD

Reiter's syndrome

Term
The HLA subtype B8 is associated with ___
Definition
Grave's disease
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