Term
| Which Ig crosses the placenta? |
|
Definition
|
|
Term
| Which Ig neutralizes bacterial toxins and viruses? |
|
Definition
|
|
Term
|
Definition
| Monomer in circulation, dimer when secreted |
|
|
Term
| How does the size of IgA change? |
|
Definition
| It picks up it's secretory component from epithelial cells before secretion |
|
|
Term
| Which Ig is an antigen receptor on the surface of B cells? |
|
Definition
|
|
Term
|
Definition
Binds mast cells and basophils and crosslinks when exposed to allergen
also activates eosinophils against worms |
|
|
Term
| Which Ig is normally in lowest concentration serum? |
|
Definition
|
|
Term
| C1 esterase inhibitor deficiency (complement deficiency) causes what problem(s)? |
|
Definition
Hereditary angioedema
ACE inhibitors are contraindicated in this disease |
|
|
Term
| C3 deficiency (complement deficiency) causes what problem(s)? |
|
Definition
| Severe, recurrent pyogenic sinus and respiratory tract infections, also increased suceptibility to type III hypersensitivity reactions |
|
|
Term
| C5-C9 deficiency (complement deficiency) causes what problem(s)? |
|
Definition
| recurrent Neisseria bacteremia |
|
|
Term
| DAF (GPI anchored enzyme) deficiency causes what problem(s)? |
|
Definition
| complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria (PNH) |
|
|
Term
| What cell secretes IL-1 and what is the action of this cytokine? |
|
Definition
Macrophage
Endogenous pyogen- causes fever, acute inflammation. Activates endothelium to express adhesion molecules; induces chemokine secretion to recruit leukocytes |
|
|
Term
| What cell secretes IL-6 and what is the action of this cytokine? |
|
Definition
Macrophages or Th2 cells
Endogenous pyogen. Causes fever and stimulates production of acute-phase-proteins. |
|
|
Term
| What cell secretes IL-8 and what is the action of this cytokine? |
|
Definition
Macrophage
Major chemotactic factor for neutrophils. |
|
|
Term
| What cell secretes IL-12 and what is the action of this cytokine? |
|
Definition
Macrophage and B cells
Induces differentiation of T cells into Th1 cells. Activates NK cells. |
|
|
Term
| What cell secretes TNFα and what is the action of this cytokine? |
|
Definition
Macrophage
Mediates septic shock. Activates endothelium. Causes leukocyte recruitment, vascular leak. |
|
|
Term
| What cell secretes IL-3 and what is the action of this cytokine? |
|
Definition
All T cells
Supports growth and differentiation of bone marrow stem cells. |
|
|
Term
| What cell secretes IL-2 and what is the action of this cytokine? |
|
Definition
Th1 cell
Stimulates growth of helper and cytotoxic T cells. |
|
|
Term
| What cell secretes Interferon-γ and what is the action of this cytokine? |
|
Definition
Th1 cell
Activates macrophages and Th1 cells. Suppresses Th2 cells. Has antiviral and antitumor properties. |
|
|
Term
| What cell secretes IL-4 and what is the action of this cytokine? |
|
Definition
Th2 cells
Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG. |
|
|
Term
| What cell secretes IL-5 and what is the action of this cytokine? |
|
Definition
Th2 cells
Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates growth and differentiation of eosinophils. |
|
|
Term
| What cell secretes IL-10 and what is the action of this cytokine? |
|
Definition
Th2 cells and regulatory T cells
Modulates inflammatory response. Inhibits actions of activated T cells and Th1. Activates Th2. |
|
|
Term
| 2 cytokines that are anti-inflammatory |
|
Definition
|
|
