Term
Nonspecific immunity (present @ birth). 1st line of host defense following antigen exposure, because it protects the host s remembering prior contact c an infectious agent.
Can be divded intop 2 stages: Immediate-occurs w/in 4hrs. Delayed-Occurs b/t 4-96hrs |
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Definition
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Term
| (Adaptive) Specific immunity that develops after birth. Usually develops as a result of prior exposure to an antigen thru immunization or by contracting a disease, both of which generate a protective immune response. This form relies on recognition of a specific foreign antigen. |
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Definition
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Term
Primary Immunodificiency
Phagocytic Dysfx:
Clinical manifestations
-Increased incidence of bacterial/fungal/viral infections caused by normally nonpathogenic organisms or candida/herpes simplex or zoster. (can no longer fight off)
-Death from overwhelming infection is abt 10% in pts c severe neutropenia.
-_______________________________ |
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Definition
-Recurrent infectons, Sinusitis, otitis media, resp infections
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Term
Primary Immunodefiency
Phagocytic Dysfx.
What to assess for?
-Hx of recurrent infections
-Failure of infection to resolve c usual tx.
-Failure of infant to gain wt or grow normally.
-Recurrent, deep skin or organ abscesses.
-Fam hx of primary immune deficiency
-Need for IV antibiotics to clear infections.
-Persistent thrush in mouth or elsewhere on skin, after age 1.
5 more??
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Definition
-8 or more new ear infections w/in 1 year.
-2 or more serious sinus infections w/in 1 yr.
-2 or more months on antibiotics c little effect.
-2 or more pneumonias w/in 1 yr.
-2 or more deep-seated infections such as meningitis, osteomyelitits, cellulitis, or sepsis.
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Term
Primary Immunodificencies
Phagocytic Dysfx
Med Mgt:
1.Stem cell transplant
2.Caution c: _____
3.______
4.Med given: ____ |
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Definition
2. Caution c: Prophylactic tx. Can develop resistance.
3. Neutropenic precautions-prevent infection.
4. Neupogen- Stimulates growth of wbcs
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Term
Primary Immunodeficiencies
B Cell Deficiencies
Clinical manifestations:
1. rercurrent infections
2. Increased risk for autoimmune diseases
3. _____
4. ____
5._____ |
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Definition
3. Pernicious Anemia- decreased rbcs d/t intestines can't properly absorb vit b12. No intrinsic factor.
4. GI symp: gastic atrophy, malabsorption, chronic diarrhea
5. Chronic lung disease |
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Term
Primary Immunod
T Cell Deficiency
ex. DiGeorge Syndrome
Clinical Manifestations:
1. cleft palate & lips
2. Dysmorphic facial features
3. VERY susceptible to childhood diseases: Infection c candida is almost universal in pts c t cell deficiencies.
4.__
5.__
6.__ |
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Definition
4. hypoparathyroidism/hypocalcemia
5. Renal abnormalities
6. Congenital heart disease |
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Term
T cell deficiency
med mgt:
1. IVIG may be used
2. manage hypocalcemia
3. tx of organs that're causing symptoms
4.__
5.__ |
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Definition
4. Prophylaxis is actually used for opportunistic infections.
5. T cell fx can improve & normalize @ abt 5 yrs of age. |
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Term
Primary Infection (Acute HIV Syndrome)
Characterized by:
1. HIV spreads thru out body
2. high levels of viral replication
3. destruction of cd4+ T cells
4.___
5.___
6.___ |
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Definition
4. Fever
5. Skin rash
6. Pharyngitis, flu like symptoms
*S&S d/t still having immune syst in the beginning stage. Immune syst is creating a response. |
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Term
HIV Symptomatic Category B
Ex of conditions r/t cat. B:
1. Oropharyngeal or vaginal candida (persistant/recurrent)
2. Pelvic inflammatory disease
3. Peripheral neuropathy |
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Definition
4. Fever or diarrhea-lasts more than 1 month.
5. Cervical dysplasia/ cervical cancers
6. Idiopathic thrombocytopenic purpura (ITP) |
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Term
AIDs category C
Ex. of conditions r/t cat. C:
1. Neuro involvement
2. Recurrent pneumonia
3. Kaposi's sarcoma
4. wasting syndrome
5. cervcal cancer
6.___
7.___
8.___ |
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Definition
6. Fungal resp infections
7. encephalopathy
8. cytomegalovirus disease |
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