Term
| MHC I: antigen pres to cells |
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Definition
| 1) protesome digests intracellular protein products; 2) TAP transported digested protein products to ER & loads them to MHC I; 3) Golgi MHC I + peptide complex go through vesicular traff. via golgi; 4) MHC I peptide presented at cell surface |
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Term
| MHC II antigen pres to cells |
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Definition
| 1) MHC II alpha + beta chains made in ER; 2) MHC II bound to invariant chain(w/o invariant chain MHC II will not leave ER); 3) MHC II + invariant chain traff to Golgi; 4) external antigens endocytosed, usually by receptor mediated endocytosis; 5) MHC II vesicles fuse with late endosomes becoming acidifed causing degradation of invariant chain leaving Clip; 6) HLA-DM catalyzes entire Clip peptide |
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Term
| MHC I interacting partner |
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Definition
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Term
| MHC II interacting partner |
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Definition
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Term
| MHC I: source of peptides |
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Definition
| internal proteins, usually degraded by protesome |
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Term
| MHC I: average peptide length |
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Definition
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Term
| MHC I: Tissue distribution |
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Definition
| Almost all nucleated cells |
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Term
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Definition
| 1 chain (+ beta 2 microglobin) |
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Term
| MHC II: source of peptides |
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Definition
| extracellular space, inmportant in endocytosis |
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Term
| MHC II: average peptide length |
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Definition
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Term
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Definition
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Term
| what is cross presentation? |
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Definition
| a rare process found usually in dendritic cells. Means there is an alternate Class I pathway, have leaky endosomes allow extracellular peptides to be presented on MHC I. Alternate MHC II class pathway transported to early endosomes where encounter intracellular peptides. |
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Term
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Definition
| Like MHC I but binds and presents hydrophobic antigens, e.g. mycobacterial glycoproteins and other lipids |
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Term
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Definition
| Like MHC II, but not polymorphic, helps catalyze CLIP and peptide exchange in late endosome |
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Term
| Naive T cell activation: where? |
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Definition
| secondary lymphoid tissue |
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Term
| drug classes that inhibit T cell signaling |
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Definition
| 1) Tacrolimus binds intracellular partner-> inhibits calcineurin 2) Rapamycin inhibits MTOR blocks AP1 activation, inhibits AP1 signal transduction (glucocorticoids also block AP1) 3) Daclizumab-anti-IL2 receptor (humanized mouse antibody) |
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Term
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Definition
| promotes killing of intracellular pathogens |
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Term
| Th1: important developmental cytokines and their sources |
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Definition
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Term
| Th1: cytokines produced by T cell subset |
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Definition
| IFN-gamma (important for macrophages eating and digesting) |
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Term
| Th1: transcription factor regulating differentiation |
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Definition
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Term
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Definition
| stimulate B cells to produce antibody. IgE against multicellular extracellular parasites and allergy |
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Term
| Th2: important developmental cytokines and sources |
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Definition
| IL-4, most important for Th2 development |
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Term
| Th2: cytokines produced by T cell subset |
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Definition
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Term
| Th2: trans factor regulating dif |
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Definition
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Term
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Definition
| involved in fighting some bacterial and fungal infections (involved in autoimmune processes) |
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Term
| Th17: import deveo cytokines and sources |
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Definition
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Term
| Th17: cytokines produced by T cell subset |
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Definition
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Term
| Th 17: transcription factor reg diff |
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Definition
| ROR gamma T (orphan trans factor) |
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Term
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Definition
| provide t cell help (critical to B cell maturation, found in follicles) |
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Term
| T foll important deveo cytokines and their sources |
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Definition
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Term
| T follicular cytokines produced by T cell subset |
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Definition
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Term
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Definition
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Term
| pathogens targeted by CD8 cytotoxic t cells |
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Definition
| intracellular-viruses, cytokines: INF gamma, TNF alpha and TNF beta |
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Term
| CD8 T cell cytokines: Inf gamma, tnf alpha, tnf beta |
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Definition
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Term
| mechanisms of cytotoxicity (CD8) |
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Definition
| 1) Fas, fas ligand (nonsecrotory lysis); 2) Granzyme perforin, secretory lysis |
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Term
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Definition
| 1) catabolism of internal organelles; 2) Fragment DNA; 3) membrane blebbing |
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