Term
|
Definition
Immunogen: Immunogen initiates adaptive
response. Larger is more effective.
(More receptors)
Antigen(Ag): substance recognized or
bound by specific antibodies(or BCR)
or T cell receptor
All immunogens are antigens.
Not all Antigens are immunogens. |
|
|
Term
|
Definition
region of antigen in direct contact
with antibody, BCR, or TCR.
Linear Epitopes recognized by T cells(
Must be processed and presented onMHC)
Antibody against hapten
Antibody against carrier
antibody against hapten-carrier neoepitope |
|
|
Term
|
Definition
Small molecule which can induce an immune response if bound to carrier
Penicillin can form covalent bonds with
proteins to produce protein-drug
adduct. Allergy |
|
|
Term
|
Definition
Receptor:
B cell - Membrane Ig-> Ag
T cell - TCR -> Ag/MHC
T cells only bind linear protein epitopes.
T cells do not bind soluble antigen
T cells see protein not hapten |
|
|
Term
|
Definition
Glycoprotein: Influenza
Glycolipid: ABO antigens
Polysaccharide: bacterial.capsular sugar |
|
|
Term
|
Definition
CD3: Pan T cell marker
CD4: T helper cell(Th)
CD8: cytotoxic T cells
CD19: Pan B cell Marker
CD56: NK cell marker |
|
|
Term
|
Definition
| 7. The TCR(T-cell receptor) of every T cell recognizes some residues of the peptide and some (polymorphic)residues on the MHC molecule duel specificity |
|
|
Term
|
Definition
Nucleic acids and phospholipids:
Not highly immunogenic
Proteins: best immunogens. Mediate cell
and humoral
Lipids and glycolipids can induce cell
mediated immunitiy |
|
|
Term
|
Definition
B cell Receptor(BCR)
Immunoglobulin(Ig)= Antibody(Ab)
Antigen binding site = variable region
Constant region = Ig class(Isotype) |
|
|
Term
|
Definition
H chain define class and subclass of Ig
Constant regions of H chain define
function
Fab = Light/heavy(variable antigen
binding region)
Fc = Heavy region. Can activate
complement pathway (C1Q) |
|
|
Term
| Specificity of antibodies |
|
Definition
Specificity is determined by Hypervariable regions(CDRs) within variable
region.
These regions directly contact Antigen
An Ag binding site is composed of 3 light and 3 heavy CDRs
CDR = complementarity determining region |
|
|
Term
|
Definition
Affinity is just the binding FIT
(Just a single bond)
Avidity is often synergistic, greater
then the sum of the affinities.
(multiple bonds are greater then the sum of their individual strengths) |
|
|
Term
|
Definition
IgG: Circulating. Primary after first
encounter. Crosses placenta
IgM: Antigen Receptor on B cells.
Released during primary response
IgD: Cell surface receptor of mature B
cell
IGA: Secretions; protects mucousal
IgE: Found on Mast and Basophils.
Triggers release of histamine |
|
|
Term
|
Definition
FcR: receptor for transplacental tranfsfer
FcR carries IgG across endothelium into
Extracellular spaces |
|
|
Term
|
Definition
Isotype: Present in all individuals of a
species.(IgA 1,2. IgG 1,2,3,4 are all
separate Isotypes)
Allotype: Different alleles within a
species. (amino acid difference, myIgG
Fc region is different than yours)
Idiotypic: Unique to a binding site(in
Fab region, variable) specific for
antigen |
|
|
Term
|
Definition
Class: IgA, IgD, IgE, etc
Subclass: IgG1, IgG2, IgG3 |
|
|
Term
|
Definition
TCR,BCR, MHC all are in the same family as Immunoglobulin.
All have subunits that are also found in Ig |
|
|
