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Immuno 2
Cytokines
35
Immunology
Post-Graduate
05/19/2012

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Cards

Term
IL-2
Definition
Induces T cell development (proliferation, differentiation, activation)
Term
IFN gamma
Definition
Induces Macrophage development
Term
IL-10
Definition
Inhibits T cell and Macrophage development
Term
IL-12
Definition
Induces Th1 development
Term
IL-2, IFN gamma
Definition
secreted by Th1
Term
IL-4, IL-5, IL-10
Definition
secreted by Th2
Term
Th2 cytokine, inhibits Th1
Definition
IL-10
Term
Th1 cytokine, inhibits Th2
Definition
IFN gamma
Term
enhance NK cell activity
Definition
IL-12; IFN-beta; IFN-alpha
Term
IL-1
Definition
acute phase cytokine
released by macrophages
Term
IL-6
Definition
acute phase cytokine
released by macrophages
Term
TNF-alpha
Definition
acute phase cytokine
released by macrophages
Term
HOT T-Bone stEAk
Definition
IL-1: fever (hot)
IL-2: stimulates T cells
IL-3: stimulates Bone marrow
IL-4: stimulates IgE production
IL-5: stimulates IgA production
Term
Cytokines made by Macrophages
Definition
IL-1
IL-6
TNF-alpha
IL-8
IL-12
Term
Cytokines made by T cells
Definition
IL-3 (stimulates BM)
Term
Cytokines from Th1 cells
Definition
IL-2; IFN gamma
Term
Cytokines from Th2 cells
Definition
IL-4, IL-5, IL-10
Term
Aldeslukin
Definition
IL-2 (renal cell carcinoma, metastatic melanoma)
Term
Filgrastim
Sargramstim
Definition
Filgrastim = G-CSF
Sargramstim = GM-CSF
Term
alpha IFN = Tx of
Definition
Hep B and C; Kaposi's sarcoma; leukemias, malignant melanoma
Term
beta- IFN = Tx of
Definition
Multiple sclerosis
Term
gamma IFN = Tx of
Definition
Chronic granulomatous disease
Term
Oprelvekin
Definition
IL-11 (tx of thrombocytopenia)
Term
Promotes B cell growth and differentiation
Definition
IL-4, IL-5
Term
Involved in growth and activation of eosinophils
Definition
IL-5 (from T bone steak)
IL-5 is "mucousy"
Term
Secreted by Th cells and activates M0
Definition
IFN-gamma
Term
Inhibits M0 activation
Definition
IL-10
Term
Pyrogens secreted by Monos and M0s
Definition
IL-1, IL-6, TNFalpha
Term
Inhibits production of Th1
Definition
IL-10
Term
Inhibits production of Th2
Definition
IFN gamma
Term
Mediate inflammation
Definition
IL-1, IL-6, TNFalpha
Term
Enhances IgE and IgG synthesis
Definition
IL-4
Term
Enhances synthesis of IgA and eos
Definition
IL-5 (mucousy)
Term
Released by virally infected cells
Definition
IFN-beta, IFN-alpha
Term
Supports growth and differentiation of BM stem cells
Definition
IL-3
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