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Function of immune system |
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protect body from foreigh antigens, identify and destroy potentially harmful cells, remove cellular debris |
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overreaction of immune system |
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autoimmune disorder is when immune system _ |
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incompetnet immune system |
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Immune system performs several functions |
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defends and protects body from infection, removes and destroys dead/damaged cells, identifies and destroys malignant cells |
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Natural immunity includes |
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Definition
physical barriers, chemical barriers, leukocyts, inflammatory response |
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Nonspecific repsonses of the immune system: |
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Definition
prevent and limity entry of invaders, limit tissue dmage, reduce immune system workload |
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example of nospecific immune response |
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activated when inflammatory process cannot destroy invaders |
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stimulate the inflammatory response and offer protection against various types of infection and foreign antigens. |
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neutrophils, lymphocytes, monocytes, eosinophils, and basophils— used in laboratory analysis |
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Leukocytoisis (>10,000) can indicate: |
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indicate inflammation, infection, some malignancies, trauma, dehydration, stress, steroid use, and thyroid storm. |
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decrease in number of circulating leukocytes |
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bone marrow activity is supressed, when leukocyte destruction increases |
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Neutrophils make up about _ of white blood cell population |
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respond first to bacterial or viral infection and alert other immune system cells to respond. |
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Percentage and numuber of circulating neutrophils is used to measure: |
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Definition
a client's risk for infection |
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fight pathogens, create manifestation in response ot allergens |
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eosinophils are related to |
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hypersensitivity reactions |
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Produce a response to allergens and other pathogens by releasing histamine and other biochemicals that can cause inflammation |
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Originate in myeloid, lymphoid cell lines |
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Dendritic cells operate in: |
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specialized dendritic cells in skin |
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WHen dendritic cells become to tolerant it can create an environment for |
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Mature in thymus & have a specific immune response |
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On contact with APCs (antigen rpesenting cells) T-lymphoctes mature into |
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Definition
active helper T cells, cytotxic T cells, memory T cells |
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Mature in bone marrow & have a specific immune response |
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Definition
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ON contact with antigen, B-lymphoctyes are activated and mature into: |
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plasma cells and secrete antibodies or memory cells |
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Natural killer cells are activated by _ and released by |
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Natural killer cells are located in |
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spleen, lymph nodes, bone marrow, blood |
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Antibodies are produced in response to an antigen. |
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Active immunity provides _ immunity |
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Active immunity involves: |
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Active immunity produces specific antibodies against |
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Antibodies are produced by an external source. |
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passive immmunity is _ immunity that does not have _ of past exposures |
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the body's first line of defense |
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passive immunity includes |
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Mucous membranes, secretions, enzymes, phagocytic cells, and protective proteins |
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regulation of cells and nasopharyngeal cavity |
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allergic reactions, anaphylaxis |
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Cell mediated immunity attacks antigens directly bye |
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In primary immune response _ cell produces antibodies to eliminate extracellular antigens |
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In primary immune response antibodies _ |
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react specifically to that antigen |
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Primary immune response takes |
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Subsequent encounters with an antigen trigger memory cells |
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secondary immune response |
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recovers proteins for vascular system and protects blood stream from invading organisms |
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foregin products or antigens |
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produces and stores hematopoetic stem cells |
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Lymphoid tissues diffuse collections of |
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lymphocytes, plasma cells, phagocytes |
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secreted to coat mucosal cells and prevent bacteria attachment |
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protect from inhaled, ingested, foreign agents |
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largest lymphoid organ that filters blood |
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Two kinds of spleen tissue |
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lymphoid prliferation, immune serveilance |
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blood filtration, removes debris, foreign matter from blood |
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stores blood and breakdown products of RBCs for future use |
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during fetal life and childhood _ is the site for maturation and dfferentiation of thymic lymphoid cells |
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refers to neutrophils and macrophages and their work as phagocytes |
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eat and destroy microorganisms, thereby helping to protect the body from harm |
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both _ are releasd during the inflammatory response |
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Hypersensitivity reactions |
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Definition
type I, Type II, Type III, Type IV |
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cytotoxic hypersensitivity |
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Type III hypersensitivity |
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delayed-type hypersnesitivity |
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Immune system loses ability to distinguish self from other and attacks own body |
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hyperacute rejection, acute rejection, chronic rejection |
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hyperacute rejection occurs |
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minutes or hours after transplantation |
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weeks after transplantaion |
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months after transplantation |
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Primary immun deficiences are |
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Secondary immune deificiencies typically result from |
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trauma, stress, cancer therapies, AIDS resulting from HIV |
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The only immunoglobulin that crosses placenta |
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maternal IgG disappears by |
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Cell-mediated immunity acheives full function _ |
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