- epitope recognition of these two immunoglobulins creates all five types of antibodies

sIgM and sIgD

- these are the co-receptors for sIgM BcR receptors and they initiate intracellular signaling pathways

Iga and IgB

- a T-Dependent antigen requires this secondary linkage between the B lymphocytes and the T Helper cells before cytokines are produced

CD40<--->CD40L

- the first signal in B cell proliferation requires binding of this type of antigen

T-Dependent Antigen

- most common antibody (75-80% of total)

- has four subisotypes (which differ at the hinge only)

- ONLY antibody that can cross the placenta

- activates complement, neutralizes toxins and viruses, immobilizes mobile bacteria, coats it for phagocytosis

IgG

- predominant subclass of IgG

IgG1

- type of immunity passed from mother to fetus via IgG crossing the placenta via FcRn

- Example: anti-tetanus toxin

Passive Humoral Immunity

- FcRn have a similar structure to this type of molecule

MHC Class I

- number of FcRn required to bind to IgG to successfully transfer it from the maternal blood to the extracellular spaces

2

- order in which Ig's are synthesized from fetal life into birth

GAMDE (16,4,2,1ish,symptomatic)

- IgG can form lattice formations via these 2 mechanisms

Agglutination (clumping of insoluble antigens)

&

Precipitation

- after an Fc binds a NK cell the natural killer is called this

Antibody-dependent, cell-mediated cytotoxic cell (ADCC)

- abbreviation/receptor associated with Natural Killer cells

CD16

- called the secretory antibody because it is bound in MALT, GALT, GI and respiratory tracts

- found in serum as monomer and as a dimer in secretions (saliva, mucus, sweat, tears, milk [colostrum], GI fluid)

- DOES NOT activate complement

- good with antivirus

- has 4 constant domains

IgA

- the cysteine-rich joining component of IgA that creates the dimer in preparation of secretion

J chain

- the J chain joins these parts of IgA

Heavy chains

- the stabilizing secretory component that protects the IgA2 dimer from proteolysis originates on this

- mediates the transport of the IgA dimer to the luminal surface

Poly-Ig receptor

- 19s gammaglobulin with a mw of 900000

- pentameric with 4 constant domains

- primary activator of complement

- the antibody involved in the natural RBC antigen recognition of the ABO blood groups

IgM

- an elevated IgM level could indicate this condition and time frame

Recent infection

(because IgM is 1st to appear in response to antigenic stimulation)

- elevated levels of IgM can indicate congenital or perinatal infections in this population

Fetus/Newborn

- antibody that is most susceptible to proteolytic degradation

- usually associated with sIgM on B lymphocytes

- first identified in a case of multiple myeloma

IgD

- the cytotrophic/reaginic antibody primarily associated with allergies

- has a very low half life (2 days) in circulation, but can persist on mast cells and basophils for MUCH longer

- causes an immediate hypersensitivity to allergens

- can protect against certain worm infections (Helminths)

IgE

- cell surface molecules with polypeptide chains with folded regions or domains can belond to this group

Ig (gene) Superfamily

- phase of the humoral immune response that occurs just after the primary vaccination (or antigen exposure)

- IgM appears 1st followed by IgG

~ 1-2 weeks in duration

Lag phase

- following the exponential phase where antibody production is amplified, this phase represents the balance of production and degradation

Steady State

- these cells are triggered following an anamnestic, secondary or booster response

memory B cells

- this effect is experienced regarding the lag phase following a secondary response to the same antigen

- this effect is experienced regarding the production of IgG following an anamnestic response

shorter lag phase

greater production of IgG for longer

- this is given to a mother post-delivery when she gives birth to her first Rh+ baby as an Rh- mother

- hemolytic disease of the newborn can preceed administration of this

- constitutes artificial passive immunity

Rhogam