Term
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Definition
| B cell that actively secretes antibodies |
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Term
| Define: affinity vs avidity |
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Definition
strength of a binding between a single binding site between molecule & ligand
avidity: overall strength of the interaction between two molecules |
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Term
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Definition
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Term
| 5 antibody isotypes & their characteristics |
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Definition
IgG - prodominant in serum
IgM - largest immunoglobulin, primary response
IgA - mucus
IgE - parasites, allergies
IgD - immature lymphocytes |
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Term
| T dependent vs independent antibody responses, nature of the antigens they target |
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Definition
T-dependent
-protein antigen response, need CD4 to be fully effective)
T independent
-polysacchrides, lipids, non-protein antigens that don't require helper T cells |
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Term
| Effector functions of antibodies |
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Definition
Agglutinaton
Precipitation
C activatoin
Cytolysis
Opsonization
Neutralization |
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Term
| How monoclonal antibodies are made |
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Definition
| Myeloma cell (cancerous plasma cell) fuses with a normal plasma cell, producing a new cell line that can produce huge numbers of antibodies, and have the specificity of the normal cell. |
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Term
| Difference between antigens recognized by B cells vs T cells |
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Definition
T cells recognize epitopes after an antigen has been taken up, processed and the epitope is presented on the cell surface
B cells recognize protein/lipid polysaccharides in their native form |
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Term
| Helper T cells respond only to... |
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Definition
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