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6-IHD
Ischemic Heart Disease
39
Biochemistry
Graduate
10/20/2017

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Term
Ischemia
Definition
Restriction of Blood flow causing damage/dysfunction in tissue
Term
Angina
Definition
chest pain due to ischemia
Term
Infarction
Definition
tissue necrosis due to lack of O2
Term
Acute MI
Definition
NSTEMI
STEMI
Term
NSTEMI
Definition
ST DEPRESSION
T WAVE INVERSION ON EKG
Thrombus incompletely occludes vessel
Term
STEMI
Definition
ST elevation or New left bundle branch block on ECG
Thrombus completely occludes vessel.Abrupt stop in blood flow
Term
Gold standard in diagnosing IHD
Definition
STRESS TEST
-Treadmill
-or Pharmacological
Term
Percutaneous Coronary Intervention (PCI)
Definition
-For pt w/ uncomplicated CAD
-Catheter inserted via femoral,brachial, or radial arteries
Guided to blockage and opens it
Term
CABG - Coronary Artery Bypass Graft
Definition
Open heart surgery
-for pt w/ complex&diffuse CAD
-vessels taken from other parts of body and used to bypass affected sections of coronary artery
Term
STATINS
Definition
-IF STATINS CANNOT BE USED CONSIDER BILE ACID SEQUESTRANT
-
Term
ASPIRIN
Definition
RECOMMENDED FORR ALL PTs (IN ABSENCE OF CONTRAINDICATIONS)
Term
ASPIRIN+CLOPIDOGREL BENEFICIAL IN
Definition
mi, ISCHEMIC STROKE,OR SYMPTOMATIC PAD
Term
CLOPIDEGREL REASONABLE IF
Definition
ASPIRIN CONTRAINDICATED OR NOT TOLERATED
Term
ACE INHIBITORS CONSIDERED IN
Definition
HX OF
HTN, KIDNEY DISEASE,MI,LV DYSFUNCTION
Term
ACE INHIBITORS MAY
Definition
REDUCE THE RISK OF VASCULAR EVENTS IN OTs W/ IHD OR IHD RISK FACTORS
Term
ARB MAY BE USED IF
Definition
ACE NOT TOLERATED
Term
BETA BLOCKERS CONSIDERED FOR ALL Pts
Definition
WITH HF &/or hx of MI
Term
BETA BLOCKERS DO WHAT?
Definition
REDUCE O2 DEMAND BY REDUCING HR,MYOCARDIAL CONTRACTILITY, AND AFTER LOAD
(dose titrated to rest HR of 55-60bpm)
Term
FIRST LINE TX TO PREVENT ANGINAL Sxs
Definition
(more effective w/ nitrate)
no specific recommendation
Term
Calcium Channel blockers are for pt unable to
Definition
receive BBs
Term
Short Acting Nitrate dose
Definition
0.3-0.6
Term
Short Acting Nitrate Onset and duration
Definition
5-10 mins & duration 30 to 60 mins
Term
Short Acting Nitrate max dose
Definition
repeat in 5 mins if sx doeas not clear. max dose 0f 1.2mg in 15 minutes
Term
Long acting nitrates contraindicated in
Definition
-hypertrophic obstructive cardiomyopathy
-severe aortic valve stenosis
-w/ PDE-5 Inhibitors
Term
Ranolazine MOA
Definition
Inhibits late inward NA+ current
-reduces O2 demand by decreasing LV wall tension
Term
Ranolazine is ______line of therapyif _______
Definition
Ranolazine is 2nd Line if Beta Blocker cant be used
Term
Ranolazine can be combined with
Definition
BBs, NITRATES, or DHP CCBs
Term
This combo causes QT prolongation
Definition
NON-DHPs & Ranolazine
Term
Ranolaziine effect on HR
Definition
NO EFFECT ON HR!!!!!!!
Term
Ranolazine Dose
Definition
500-100mg bid
Term
Ranolazine Side effects
Definition
CONSTIPATION, Nausea, dizziness,HA
Term
Pt should receive _________to reduce mortality and morbidity in pt w/ underlying CV conditions
Definition
ANNUAL FLU SHOT
Term
CCBs are first line for
Definition
-chronic Tx
Which ccbis based on pt conditions
Term
CYP2c19 *1/*17, *17/*17
Definition
-Clopidogrel Standard dose
rapid
and ultrrapid metabolizer
Term
CYP2c19 *1/*1
Definition
-Clopidogrel at a standard dose
normal metabolizer
Term
CYP2c19 *1/*2 & *2/*2
Definition
Im and PM
Alternative like Prasugrel(EFFIENT) ot Ticagrelor(BRILLINTA)
Term
SLCO1B1 TT
Definition
Normal Function (55-88% prevalence)
Term
SLCO1B1 TC
Definition
Intermediate Function (11-36% Prevalence)
-prescribe low dose or other statin
DEC statin clearence inc statin concentration (strongly recommended)
Term
SLCO1B1 CC
Definition
LOW FUNCTION (0-6% Prevalence)
-prescribe low dose or other statin
DEC statin clearence inc statin concentration
-check CK (strongly recommended)
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