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Ig isotypes
Ig isotypes
5
Medical
Graduate
10/30/2010

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Term
IgG
Definition
monomer, 23 day half life, Highest concentration in serum
Activates compliment
Placental transport
Binding to phagocyte Fc receptors
Binding to Fc receptors on Natural killer cells
Term
IgM
Definition
pantamer (in solution), 5 day half life, average concentration in serum
Activates classical pathway
Mucosal epithelial transport
Antigen activator of B cells
Term
IgA
Definition
dimer, 6 day half life, med-high concentration in serum
Mucosal epithelial transport
Term
IgE
Definition
monomer, very low, 2 day half life, very low concentration in serum
mast cell degranulation
Term
IgD
Definition
monomer, low serum concnetration, 3 day half life
Antigen activator for B cells
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