Term
| when did resurgence of tuberculosis hit US? |
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Definition
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Term
| most new cases come from what citizens? |
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Definition
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Term
| TB is _ prevelant infectious disease? |
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Definition
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Term
| how is tuberculosis transmitted? |
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Definition
| droplet nuceli (coughing, sneezing) |
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Term
| how long do you need direct contact to contract TB? |
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Definition
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Term
| risk factros for aquiring TB-6 |
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Definition
exposure to TB person
geography
HIV
race
adult |
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Term
| which gender has higher chance for getting TB |
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Definition
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Term
| aveolar macrophages ingest _% of bacteria |
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Definition
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Term
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Definition
CD4 actiavte macrophages
macrophages eat bacteria
left over bacteria multiple in macrophage and release on its death
the new bacteria attract more macrophages-> granulomas |
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Term
| host develops antibodies after _ weeks |
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Definition
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Term
| in healthy patients what are the only sequellae? |
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Definition
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Term
| _% of exposed persons go to active disease |
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Definition
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Term
| granuloma that is stable, limit spread of infection |
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Definition
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Term
| granuloma that is unstable, cheese-like, tissue destruction and spread of TB |
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Definition
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Term
| adaptive immune response causes 2 things |
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Definition
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Term
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Definition
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Term
| risk factros for devloping active disease- 5 |
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Definition
children, elderly (2-5x)
renal failure, cancer (4-16 x)
HIV (100x more risk) |
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|
Term
presentaiton of active disease-
normal symptoms- 3
pulmonary-3 |
|
Definition
low fever, night sweats, decreased appetite
cough, hemoptysis, chest pain |
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Term
| what test do you use with sputum |
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Definition
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Term
| how is TB skin test admin |
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Definition
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Term
positive test for TB skin test:
no risk factros:
at risk and recent immigration:
HIV, immunosuppression: |
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Definition
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Term
| how long do you have to wait to do a TB skin test |
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Definition
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Term
| who do you never do a TB skin test on? |
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Definition
previous positive TST
previous TB treatment |
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Term
| what test is used to determine disease status? |
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Definition
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Term
| Latent Infection diaagnosis - 4 things |
|
Definition
no symptoms
TST, IGRA +
normal chest radiograph
resp cultrue negative |
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Term
| Active Disease diagnosis- 4 things |
|
Definition
symptoms present
TST, IGRA usually +
typically normal radiogrpah
resp smear is pos. |
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Term
| treatment of latent TB should be given to those with a pos. ? |
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Definition
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Term
| groups at risk of recent infection (treat for risk of active disease) |
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Definition
| homeless, healthcare worker, long term care |
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Term
| with tuberculosis meds what monitoring is needed |
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Definition
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Term
| higher rates of INH tox in ages> |
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Definition
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Term
| non pharmacologic care for active TB- 4 |
|
Definition
respiratory isolation
contact investigation
nutrition
notify health department |
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|
Term
what 3 mycobacteria does active TB treatment cover?
whihc is the largest group? |
|
Definition
extracellular in cavities
mycobacterium in caseating grans
intracell in macrophages;
extracell |
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Term
| TB consists of _ intitation phase and _ continuation phase - except HIV always treat for _ months |
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Definition
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Term
MDR and extrememly drug resisitant tuberculosis require _ # of drugs
how long do you treaT? |
|
Definition
4
18 months after negative culture |
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Term
monitoring:
do culture and sensitivity follow up in _ months |
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Definition
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