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ID Exam 3
C. diff
26
Anthropology
5th Grade
11/06/2012

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Cards

Term
when does c. diff occur?
Definition
2-3 weeks after ABX
Term
c diff causes - % of AAD
Definition
15-25
Term
microbio of c diff
Definition
gram pos rod- anaerobe
spore forming
Term
what causes the symptoms of c.diff?
Definition
its toxins
Term
common ABXs that cause C diff
Definition
clindamycin, FQs, Cephs, ampicillin
Term
less common ABXs that cause C diff
Definition
AGs, erythromycin, vancomycin, flagyl, bactrim
Term
general symtpoms of c. diff
Definition
diarrhea
fever
cramps
increased WBC
Term
symptoms caused by toxin A
Definition
inflammatory, mucus damage, fluid secretion
Term
symtpoms caused by Toxin B
Definition
intense mucosal damage
Term
signs of mild c diff
Definition
no fever, cramping, patchy nonspecific colitis
Term
signs of moderate c diff
Definition
fever, cramping, nausea, profuse diarrhea
Term
which type of c .diff starts to have leukocytpenia
Definition
moderate
Term
signs of severe c diff
Definition
fever, cramping, yellow plagues shown on endoscopy
Term
which is the most sensitive diagnostic tool
Definition
stool culture
Term
what is the cons about stool cultures
Definition
turnaround time
false positives
Term
what is the diagnostic test used by most hospitals
Definition
ELISA
Term
what are the pros and cons about ELISA
Definition
pro: cheap, quick
cons: not sens, not spec, suboptimal for diagnosis
Term
what test is rapid but expensive
Definition
PCR
Term
what would you reccomend for treatment of C diff
Definition
stop causing agent if can
supportive: fluids
ABX
Term
flagyl and vancocin have _ % reccurence rate
Definition
20
Term
what are the mRNA synth inhibitors (nucleic acid)
Definition
rifaximin
fidaxomicin
Term
what is the moa of nitazoxanide
Definition
inhibits anaerobe pyruvate metab
Term
what alternative med can be used right afterr vanc?
right after flagyl?
Definition
rifaximin
nitazoxanide
Term
what alt med only has local GI effect
Definition
rifaximin
Term
fidaxomicin is only used in?
what orgs isnt it good against?
Definition
mild/mod c diff
G -
Term
moa of tigecycline
what type of c diff used in?
Definition
inhibits 30 S
severe
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