Some: Staph Aureus

Strains: Strep Pneumo

Have: H. Flu

Pretty: Pseudamonas

Nice: N. Gonnohrea (pseudo)

Capsules

HSV 1, 2 and VZV

A: absorption is poor

C: CSF

T: TK phsophorylates

U: Urine excretion

P: Pregnancy safe

C: Common resistance

U: urine

P: Prodrug

O: Oral

F: Food decreases side effects

B: Influenza B

A: Influenza a

C: Category C in pregnancy

O: Oseltamivir

N: Neuraminidase inhibitor

M: M2 channel blocker

C: CNS side effects (nervousness, insomnia, confusion)

A: Influenza A

T: Teratogenic

S: Swine flu is resistant

Emtricitabline

Lamivudine

Zidovudine

Tenofovir

Emi and Lami = Cytidine

Zido and Teno (nucleotide) = Thymidine

P: Peripheral Neuropathy

A: Acidosis

N: NRTI

D: Diarrhea

A: Allergy

Oral Ulcers

Efavirenz

Etravirine

EtraviriNE (Non Enzymatic)

EfavirENZ (ENZymatic)

CNS penetration, Lipodystrophy, Enzyme changes confirmation, not additive, rashes

NNRTI

Nelfinavir

Ritonavir

Lopinavir

NAVIR mess with proteases

M: Metabolism of ritonavir blocks destruction of lopinavir

I: Interactions of drugs (some good, some bad)

L: Lipodystrophy

D: Diabetes

G: GI Toxicity

I: Infected cells not affected

M: MI

P: Protease inhibitor

enFUvirtide = FUsion inhibitor

BE SPIFF

B: Both CCR5 and CXCR4

E: eosinophilia

S: Subcutaneous

P: Pneumonia from bacteria more common

I: Inflammation @ injection site

F: gp Fourty one

F: Fusion

Fusion Inhibitor

ROACH

R: rash from crystals

O: gp One 20 w/CCR5

A: assay for tropism

C: Cough

H: Hepatitis

Combo w/NRTI

Careful in Hepatitis

BIRD

B: Bind Divalent cations

I: Integrase inhibitor

R: Rash

D: Diarrhea

1st line for Malaria

CHAI ME TOFU

C: Cinchonism

H: High does @ first (loading dose)

A: Aluminum antacids block absorption

I: "I" issues

M: Metabolized in liver

E: Ear Issues

T: TInnitus

O: Oral

F: Flushing

U: uncommon resistance

Malaria

MOSQUITOS (<3) RAP

M: Malarone

O: Oral

S: Stool

Q: Quinine combo = BAD

U: Use before infected (prophylaxis)

I: Insomnia

T: Tummy pain (abdominal discomfort)

O: Odd behavior (psychosis)

S: Seizures

<3: Cardiac Conduction

R: Resistance (use in chloroquine reistance)

P: Protein bound

IV SCALD

I: Imipenem

V: Vancomycin

S: Second generations Cephalosporins (Cefotetan, Cefoxitan)

C: Carbapenems

A: Aminoglycosides

L: Linezolid

D: Daptomycin

Liver: MAC CELL

M: Metronidazole

A: Azithromycin

C: Clarithromycin

C: CLindamycin

E: Erythromycin

L: Linezolid

L: Liver

Fecal: Clindamycin, Tetracyclin (Doxy)

Bile: Clindamycin, 3rd gen Ceph (Cephtriaxone), Naficillin

Lamivudine

Zidovudine

NOT DOC

N: NRTI

O: Oral Ulcers

T: Thymidine (Zidovudine)

D: Diarrhea

O: OH on 3' is lacking

C: Cytidine (Lamivudine)

Carbipenems

(Imipenem, Meropenem)

w/ P. Aeru, PIC A Gorillacillin

P: Porin (can change for resistance)

I: IV

C: Cilistatin (DHP II Inhibitor) w/Imi

A: Aerobe/Anaerobe

Skin and Soft Tissue

Vanquish an INCHWORM w/a PAN

I: IV

N: Negative G's (G-)

C: C. Diff oral tx

H: Hematological side effects

W: Wall synthesis

O: Ototoxic

R: Rash

M: MRSA

P: PRSP

A: AA change = resistance in E Coli

N: Nephrotoxic

A/A or S/ST

Clindy is SHIT AT MATH

S: Stool secretion

H: Hepatic metabolism

I: Inhibit

T: toxin formation

A: Anaerobes

t: tRNA binding (protein synthesis)

M: MRSA

A: Aerobes

T: to bile

H: Help from FQ for A/A

Airhead w/ C average (C. Diff) use for C. Diff

S/ST

Lines for inhitiation are a POLAR COMMIT

P: Peripheral Neuropathy

O: Oxazolidone (inhibit protein synthesis)

L: Liver

A: Atipical RTIs

R: Resistant E. Coli (VRE's)

C: CSF penetration

O: Oral

M: MRSA

M: MAO = serotonin sickness

I: IV

T: Thrombocytopenia

RTI

 NeuD TEMPTS

Neu: resistance in s. pNEUmo

D: doxy has less resistance

T: tRNA block

E: Efflux and porins -> R of S. Pneumo

M: binds Multivalent cations

P: Photosensitivity

T: Teeth and bone discoloration, teratogenic

S: Stool

S. Pneumo has less reisstance to Dox

A/A

Metros BLOT @ FAG CAMP

B: break open DNA strands

L: LDH increased in resistant strains

O: oxidoreductase (less activity can lead to resistance)

T: Metallic taste

F: FQ helps w/A/A

A: Alcohol can lead to drug interactions

G: GI SE's

C: CSF penetration

A/A

M: Metabolized in liver

P: Pancreatitis (rare)

Levofloxacin

Cirpofloxacin

Moxifloxacin

RTI (L,M)

UTI (L,C)

Leave THAT PUTRID Cip of caffeine

T: Topoisomerase

H: Flu

A: Aeruginosa is resistant

T: tendonitis

P: PRSP

U: UTI

T: Tipicals and atipicals

R: RTI

I: Insomnia

D: Binds Divalents

Moxi has less renal secretion

Cipro + Caffein (or theophylline) = BAD

URI

Break DNA Strands, food decreases N/V

CHUMPS SAVAGED JIHADS and got malaria

C: CNS blockage = delirum, paralysis, coma, death

H: Hypoxia ->lactic acidosis and hypoglycemia

U: Urine casts in Dx

M: Maurs dots (Intracytoplasmic granules and clefts) in dx

P: Pernicious syndromes

S: Splanchnic blockage -> vomiting, Ab pain, diarrhea (can be bloody)

S: Splenomegaly (sequestered infected RBC's)

A: Anemia (Phagocytosis, sequestration, sporulation)

V: Vasodilitation -> Fever, decreased blood volume circulating, hypotension, ARDS
A: Antigenic Variation

G: Geimsa or Wright Stains

E: Elevated knobs on RBC make them sticky

D: Death in 3 days

J: Jaundice

I: Intravascular hemolysis -> dark urine, "Blackwater Fever"

H: High molecular weight adherance proteins bind to endothelium of capillaries (brain, placenta, etc...)

A: Acute renal failure

D: Doxy (prophylaxis), Malarone (prophylaxis) or Quinine

S: Spore loves Schibish bashing (Sporozoite, liver, Schizont (release merozoit) blood, shibish and his trophy wife (in blood do shizont and trophozoite (ringed form) circle)

INFAMOUS HEAP

I: Invasive: COPD or ICP, fungus balls, lethal

N: NON-oxidative

F: Fluffy fungus balls, pigmented growth

A: Allergic: worse in asthama, transient infiltrates, eosinophilia, increase specific Ab's

M: macrophages: do NON-oxidative, 1st line of defense

O: orally inhaled

U: usual fungus drugs (not fluconazole)

S: Silver and Sabourads

H: Hyphae (branching setate)

E: Extracellular elastases, proteinases, phospholipases do virulence

A: Acute Penumonia: multifocal pulmonary infiltrates expand to consolidation w/high fever

P: PMN's can't phagocytose, do ROS

S/ST

CANCER PIMP

C: Cell membrane (lose ions)

A: Allergy

N: Negatives (gram)

C: CPK in skel M

E: ELF

R: can use in R E. Coli

P: Protein bound

I: IV

M: MRSA

P: PRSP

S/ST

A/A

RTI

Crosslinking, RTI, change dose w/renal

R w/change PBP (S Pneumo), B lactamase

Hypersense, Seizure, C. Diff

Piper: IV, A/A, P Aeru

Pen G: PRSP

Amox: A/A, R in Peru

Ampi: H Flu, (30% R), PRSP

Nafi: ARMS: antistaff/renal/MRSA/S/ST

not for staff, bile, R in MRSA, S/ST

Gentamycin

Tobramycin

UTI

AMINO

A: Aerobic G-

M: Modify drug leads to inactivation and R

I: IV

N: Nephrotoxic

O: Ototoxic

Amantidine

Oseltamivir

Amant takes theMCATS SPENT

Aman:

M: M2

C: CNS issues

A: Anorexia and other GI issues

T: Teratogenic

S: Swine flu resistance

Osel:

S: Swine flu sensitive

P: Prodrug

E: eat food w/it to decrease N/V

N: Neuraminidase inhibitor

T: teratogenic

PANDA (NRTI) CEREAL (NNRTI)

P: Peripheral Neruopathy

A: Acidosis

N: Nausea

D: Diarrhea
A: Allergy

C: CNS

E: Efavirenz

R: Rash

E: Etravirine

A: Additive (NOT)

L: Lipodystrophy

UTI

Crystal SULFA

Crystalluria

S: Steven-Johnson Syndrome

U: UTI

L: Leukopenia

F: Folate

A: Anemia w/G6P

Acyclovir

Valacyclovir

ACT UP

A: Absorption is bad

C: CSF distribution

T: TK

U: Urine excreted

P: Preggers safe

RIPE BLIP

(Caspofungin)

R: Resistant Aspergillos

I: IV

P: Protein bound

E: Echinocandins

B: b-glucan

L: liver metabolism

I: INcreased CYPs

P: Phlebitis

CHIC ORCA PAD

C: CYP

H: Heptatis

I: Itraconazole

C: CHF (careful)

O: Oral

R: Rash

C: Candida

A: Aspergillos

P: Protein bound

A: Acidic stomach (needed for absorption)

D: decreased absorption w/food

CHIC HOVA CRAP

C: Candida

H: Hepatitis

I: IV

C: CSF distribution

H: Hepatitis

O: Oral

V: Voriconazole

A: Aspergillos

C: CYP

R: Rash

A: Abnormal Vision

P: Photophobia

CHIC POSER

C: CSF penetration

H: Hepatitis

I: IV

C: CYP

P: Prolonged use leads to resistance

O: Oral

S: Skin rash

E: Ergosterol binding

R: Renal

Ethan is PRO SOUR

P: Polymerization of Cell Wall

R: Retrobulbar optic neruitis

O: Overexpression of genes leads to reistance

S: Stool

O: Oral

U: Urine

R: Red/green color blindess

Visiting pyramids is ORPHAN FUN

O: Oral

R: Renal

P: Prodrug

H: Hepatic

A: Arthritis (gouty)

N: N/V

F: Fever

U: Uptake alteration leads to resistance

N: No cross resistance

Rifampin

Rifabutin

RRRR

RNA polymerase inhibition (DNA dependent RNA pol)

Revs up CYP

Red/orange body fluids

Rapid resistance if used alone

Atypicals, Drug induced SLE

MOMMI CLUB has PHAT LAG

M: Macrophage penetration

O: Oral

M: Mycolic acid syntehesis (inhibition)

M: mutations lead to reisistance

I: IV

C: CSF penetration

L: liver

U: Urine

B: Bimodal distribution

P: Peripheral Neuropathy

H: Hepatitis

A: Aluminum salts inhibit absorption

T: Tinnitus

L: Level increase w/carbamazepine and phenytoin

A: Anemia

G: GI Issues

Injures neurons and hepatocytes

BASIC LINEUP

B: Broad

A: Aspergillos

S: Systemic

I: IV

C: Candida

L: Liver

I: Infusion reaction

N: Nephrotoxic

E: Ergosterol binding

U: Uncommon resistance

P: Pretreatment

Lipid: Fat invades reticuloendothelial system (invasive aspergillos)

Infusion reactions: RANCH FIT: rigors, ampho, N, chills, hypotension, infusion rxn, tachycardia

1st: Cefazolin (highly protein bound), Cephalexin: S/ST, G+, S Aureus, Strep, NOT MRSA

F"A"

2nd: Cefoxatime: A/A, H Flu, G+, NOT oral

"FOX"

3rd: FT's,  (cetriaxone, bile)

4th: Cefepime

RTI, H Flu, G+, better for B lactamases, CNS

ALL: hypersenstivity, C. Diff, Seizures, Oral, Renal

Systemic Echinocandin

BLIP RIP

B: B-glucan

L: Liver

I: IV

P: Protein bound

R: good for Resistant candida

I: Increased metabolism w/CYP

P: Phlebitis

AMPED NYMPH BOPS TICK

A: ALL fungal drugs (ampho B, fluconazole)

M: MALT: t's help

P: PMN (1st line)

E: Esophagitis, dissemination

D: Diaper rash, chronic mucocutaenous

N: Normal flora (oral/pharangeal, GI)

Y: Yeast form

M: Mannoproteins (Stimultate B and T, bind ECM, we make an anti-mannan IgG)

P: Phospholipase and proteinases: prevent opsonization

H: Hyphal form (sprouting to germ tubes)

S: Saborauds agar

B: BAL

O:Opsonization prevented via C3 binding

P:Positive (gram +)

S:Silver stain

T: Thrush

I: Immunocompromised pts

C: Classic and alternative paths

K: KOH

MACCAWW is a BAD ACCOMPLICE

M: Microaerophilic

A: antigenic variation

C: Cefuroxime (2nd)
C: Cephtraixone (3rd if bad)

A: Amox**********

W: wright or geimsa
W: Western blot

B: bulls eye

A: Ab's (BIG PEN)

D: Doxy*********

A: Arthritis
C: CNS: meningitis, CN III palsy, peripheral neuropathy
C: CV: cardiac conduction, acute myocarditis
O: OspC
M: chronic erythema Migrans w/bulls eye, painless
P: PMN
L: LPS (different then normal): w/OspC deposities in joints, inhibit mononucs, NK, lymph proliferation and CK production
I: Immunoflurescent
C: Classic pathway
E: subtle Encephalitis

Mike'S A CANAL MAN

LAMe pnemonic w/mike and his surfboard who likes surfing in the canal and drinking RIPE malted milk

S: sturdy, hydrophobic, hard to kill, high temps

A: Acid Fast

C: CO2 needed

A: Apical on xray for gohn complexes and granuloma formation
N: Non motile
A: Acid fast
L: Lowenstein-Jensen

M: Miliary
A: Acid fast
N: makes Niacin

Mycolic acid, Sulfatides and LAM (bind alveoilar macrophages, mediate CK and T's) disrupts phagolyso fusion

Cord: Stops PMN migration, damage mito, release TNF

WaxD: activated CMI

MILC = intracell

MALT = T cells (DTH prevents reinfection)

A CAVEMAN PIPED MEEMI

A: Acute infection

C: CNS issues
A: Acyclovir
V: Valacyclovir
E: Encephalitis
M: Mononucs
A: Aseptic meningitis
N: Necrosis (focal)

P: Painful lesions
I: Intranuclear inclusions (Cowdry bodies)
P: PMN
E: Extragenital lesions
D: Degeneration of epi and fibroblasts

M: Multinuc giant cells

E: Envelop proteins on host cell allow for fusion

M: Multiple painful lesions
I: Invades NON replicating cells

IM A DEFECTIVE SHRIMP

I: Infection can be super infection

M: macrophage and monocytes at first (reticuloendothelial cells)

A: Ab's prevent infection

D: Dew on a rose petal
E:
F: Fibroblasts
E: Eosinophilic (inclusion bodies)
C: CMI prevents reactivation (t's in secondary)
T: Trunk
I: Intranuclear inclusions
V: Vaccine, Valacyclovir, Acyclovir
E: Eye (keratitis)

S: Sin
H: Herpete
R: Ramey Hunt (face palsy, ear vesicles)
I: IF
M: myelitis
P: post herpetic neuralgia

B: Box Car Medusa Head

A: Antibiotis: Doxy, Cipro (prophypaxic), Clinda

C: Cutaneous: black echar, septicemia

I: Inhalation leads to pulomary w/wide mediastinum, drug cough and eccymosis

L: LF = lethal fever (from mphages), EF: edema, inhibit PMN (via increase cAMP)

L: Live attenuated vaccine

U: unmotile

S: Spore Former

A: Antibiotics for dissemination

N: NADA (no Ab or CMI)
T: Tissue culture

H: non-hemolytic

R: Really fatal

A: ADAPINE (facultative anaerobe)

C: Cat +, G+

I: Immune = ???

S: Septocemia

BAD UN COCCI

B: brick shaped
A: Ab and CMI
D: Die from superinfection

U: Umbilicated
N: guarNeri's bodies

C: Centrifugal
O: One stage
C: Complement regulatory proteins inhibit monos and CK's
C: cytoplasmic

I: Inclusion bodies

ILOS: Infect macrophage and replicated in LN, BM and spleen, Leukos to blood, Oral (infective), Skin

PEDAGOG

P:  palms and soles

E: Enderateritis
D:Darkfield
A: Ab's on VDRL, PRP, and FTA-ABs
G:  Gummas (skin bone and joints in 3rd), w/CV and Neuro and all that fun stuff
O: Obstruction from cuffs around vessicles leads to decreased local supply, DTH, chancres, enerteritis, arteriolar swelling, necrotic ulceration (Primary)
G: Granulomatous lesions (secondary) w/mucocutaneous  maculopapular rash and non tender lymphadenopathy

Host molecular disguise, DTH to spirochetes, Humoral and CMI involved, anti-trep Ab's kill them, most of Sx are because of host response

Tx: Penicillins, w/Allegy: Erythromycin, Doxycyclin

P: Pen (desensitize)

Ulcers: Benzathane Pen G

IgG: blood, cross placenta

IgE: parasitE, mast cEll dEgranulation, immEdiated hypErsEnsitivity

IgA: mucosA, breast milkA

IgM: classical coMplement

CTL: Intracellular endogenous: Critical for viruses

Abs = effective for viruses

DTH (Th1 and 2 from CD4) = Intracellular exogenous, Fungi and parasites

B = Bacteria

CD8 = CTL

CD4 -> Th1 (NK -> IFN gamma, Mphage -> IL-12) -> IL-12 and Ifn-Gamma -> IgG

Th2 (IL-4 from somewhere) -> IL-4 (IgE) and IL-5 -> Eos and Masts (parasites!!!!)

TGF-beta (from MALT) -> IgA

Eos - parasitEs w/IgE

Basos become masts: parasites (w/Eos and IgE)

PMN and Mphage: bacteria and fungi

new OB'S CAN PMS

O: Otitis media in kids
B: Bacteremia
S:

C: Capsule, Choline binding, Choline Containing sufactant, cholin binding + PAF -> change in vascular permeability -> serous -> + WBC = purulent

A: Autolysin, Protein A (Complement interference, autorelease pneumolysin)
N: No lacefield, neuraminidase, pneumolysin (serous edema, lobar pneumonia, favors thrombosis, inflammation, CK cascade, septic shock)

P: Pneumonia
M: Meningitis
S: Sinusitis

R: change transpeptidase for cross links

Ab, Alternate, M phages

G+ Dipplococci lancet shaped

Cat -

alpha hemolytic, optochin sense, ADAPINE, extracellular (not a MILC one), Blood and Chocolate, QUellun rxn

Drugs: FAD

A PROLIFIC LO makes you a BEDPAN CHAMP

A: Phospholipase A

P: Pili
R:RNAse
O: OMP bind C3b, coiling uptake
L: LPS
I: Iron extraction
F: Flagella
I:ICM/DOT type 4 secretion (inhibit phagolysosome fusion of Mphage)

C: Phospholipase C

L: Legionella
O: Oxidative burts (Via Cu-Zn metalloprotease)

B: Bradicardia (relative)
E: Encephalopath
D: Diarrhea
P: Pancreatitis
A: Achy muscles
N: Non-specific sx

C: Chest pain (pleuritic or not)
H: Hypotension
A: Acute renal failure
M: Mental status change
P: Peritonitis

PMN, Phagocytosis, Mphages, monocytes, need some t cell help

Fibrin, less MHC I/II expression, CK stop intracellular growth bvia activating Mphages

R: Penicillins

NO person to person

X ray: asymmetric, long serology, lower lung, BAL > wash, "ground glass", Direct Fl-Ab (fast)

Aerobic, no MAC or blood agar growth, Need AA, Ferric Irons, Acidic conditions, 35-37 degrees to grow

In PAPAS pseudo FABLES

Pseudamonas

Aeruginosa

Pili

Exotoxin A

Exotoxin S

Flagella

Alkaline Protease

Biofilm in CF

LPS -> SHock and fever

Elastase -> Dissemination

S: Extracellular polysacharide slime

BE PSEUDO: Burns, endocarditis, pneumonia, sepsis, external malignant otitis media, UTI, diabetic osteomyelitis

Host: PMN, Phago, Ab's opsonize LPS, antitoxin Ab,

R: via porins and change PBP, transduction and conjugation

Lab: 37-42, minimal nutrients

Erythromycin

Clarithromycin

Azithromycin

50s

Atypicals

R: Efflux, change RBS

C/A = H Flu

Claire + statin = myositis, rhabdomyelitis (skel M breakdown)

Azith = NO DI's

SE: CYP, GI, QT

50's QT Claires G, if shes statin she gets sore and M atrophy, not typical,

Pumps iron and changes clothes alot,

Her and Azi are good for flu