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hypo/hyper thyroidism
hypo/hyper thyroidism
48
Pathology
Undergraduate 2
03/11/2011

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Cards

Term
is hypothyroidism a congenital or aquired defect?
Definition
both!
Term
congenital hypothyroidism
Definition
developes congenitally and presents at birth
Term
can a child with hypothyroidism be mentally challenged?
Definition
yes if it's not caught early they will be severelly mentally retarded
Term
what can cause hypothyroidism in an infant?
Definition
results from a congenital lack of thyroid hormone and deficient TSH
Term
cretinism
Definition
the manifestations of untreated hypothyrodism
Term
what is thyroid hormone essential for?
Definition
normal growth and bran development
Term
Transient congenital hypothyroidism
Definition
high TSH and low or normal thyroid hormones
Term
transient hypothyroidism can be caused by?
Definition
the baby being exposed to iodine, which it is very sensitive to
Term
how do we treat congenital hypothyroidism?
Definition
it is treated with hormone replacement and we have to normalize the T4 levels
Term
hypothyroidism causes?
Definition
a general slowing down of the metabolic prcoess and myxedema
Term
what is myxedema?
Definition
non pitting mucous edema
Term
why do we get the edema?
Definition
due to the accumulation of hydrophilic polysaccharides in the connective tissues
Term
what are the 3 ways that u can get hypothyroidism?
Definition
primary, secondary, and tertiary
Term
primary hypothyroidism
Definition
dsyfunction of thyroid gland. most common. 
Term
what can an iodine defficiency cause?
Definition
goiter and hypothyroidism
Term
what is the most common form of hypothyroidism?
Definition
hashimoto's thyroiditis
Term
hashimoto's
Definition
an autoimmune disorder in which the tyroid gland gets killed, common in women
Term
symptoms of hypothyroidism?
Definition
weakness, fatigue, no weight gain, large appetite, cold intolerance
Term
symptoms continued...
Definition
dry and rough skin, face is puffy, deafness, edema, constipation, bradycardia
Term
what are CNS symptoms of hypothyroidism?
Definition
mental dullness, lathargy, and impaired memory
Term
why is the tongue commonly enlarged in a patient with hypothyroidism?
Definition
due to the extra myxedemous fluid. voice is also husky. 
Term
what are other problems with hypothyroidism?
Definition
muscle stiffness, enlarged heart, deposists on heart, carpal tunnel
Term
hypothyroidism has what lab results?
Definition
a low serum t4 and elevated TSH
Term
secondary hyothyroidism
Definition
impaired pituitary gland
Term
tertiary hypothyroidism
Definition
due to impaired hypothalamic function
Term
thyrotoxicosis
Definition
when the tissues are exposed to high levels of circulating thyroid hormones
Term
what causes thyrotoxicosis?
Definition
hyperthyroidism
Term
graves disease usually has...?
Definition
opthalmopathy and diffuse goiter
Term
what are other common causes of hypertyroidism?
Definition
multinoidular goiter, adenoma of thyroid, or thyroiditis
Term
manifestations of hypertyroidism?
Definition
increase in oxygen consumption and use of metabolic fuels and an increase in sympathetic nervous systems
Term
how does thyroid hormone affect sensations in hyperthyroidism?
Definition
it hieghtens the sensations. 
Term
what are some symptoms of hyperthyroidism?
Definition
nervousness, irritability, fatiguability, weight loss, large appetite, tachycardia
Term
symptoms continued...
Definition
palpitations, heat intolerance, sweating, muscle cramps, muscle tremors
Term
symptoms continued...
Definition
exophthalamos, no blinking, hair and skin are thin
Term
graves disease
Definition
autoimmune disorder with abnormal stimulation of thyroid gland by TSH
Term
why do we get opthalmopathy in graves disease?
Definition
it is the result of cytokine mediated activation of fibroblasts in orbital tissue
Term
the hypothalamus releases ?
Definition
thyroid troping releasing hormone
Term
when the hypothalamus releases TRH, what will the anterior pituitary release?
Definition
it will release TSH
Term
what does TSH bind to?
Definition
the thyroid gland
Term
when TSh binds to the thyroid gland, it signals that the body needs?
Definition
t3 and t4
Term
in order for t3 and t4 to be released we need what?
Definition
iodine
Term
why are t3 and t4 valuable?
Definition
they are responsible for maintaining metablic rate, growth, and protein synthesis
Term
when the body has enough t3 and t4 what will happen?
Definition
the thyroid gland will tell the anterior pituitary to stop releasing TSH
Term
hashimoto's disease destroys?
Definition
the enzyme that produces t3 and t4
Term
thyrotoxicosis
Definition
too much thyroid hormone
Term
if the t3 and t4 get low what will happen?
Definition
it becomes a life threatening situation
Term
in graves disease the thyroid gland releases too much?
Definition
t3 and t4
Term
what is elevated with hyperthyroidism?
Definition
TCSH
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