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Hypertension-Skaer
Flashcards for HTN Quiz 1
46
Pharmacology
Graduate
01/17/2011

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Term
ESSENTIAL HYPERTENSION
Definition
Usually asymptomatic
Diagnosis cannot be made on one high BP
Term
SECONDARY HYPERTENSION
pathophysiolgic causes
Definition
Kidney disease, Cushing's dz, obstructive sleep apnea, parathyroid dz. coarctation of the aorta, primary aldosteronisms
Term
SECONDARY HYPERTENSION
medication causes
Definition
steroids, amphetamines, appetite suppressants, decongestants, erythropoesis agents, NSAIDS
Term
NORMAL BP
Definition
< 120/80
Term
PRE-HYPERTENSION BP
Definition
120-139/80-89
Term
STAGE 1 HYPERTENSION
Definition
140-159/90-99
Term
STAGE 2 HYPERTENSION
Definition
>160/>100
Term
HYPERTENSIVE EMERGENCY
Definition
BP greater than 180/120
Term
Strong risk for _________ even with pre-hypertension.
Definition
Stroke, heart failure, angina, sudden death,kidney failure
Term
Electrolyte risks
Definition
Excess sodium, altered calcium balance, potassium depletion
Term
Age of risk in men and women
Definition
Men 55 or older
Women 65 or older
Term
Risk factors for HTN: disease states
Definition
diabetes, dyslipidemia, obesity,microalbuminemia
Term
Risk factors for hypertension: Lifestyle
Definition
family history of early CV disease, tobacco, physical inactivity, previous BP in HTN category
Term
Labs and diagnostic testing: methods
Definition
Blood glucose (fasting),BUN, serum creatinine, lipids, electrolytes
Patient may have normal values.
Term
Diagnostic testing: methods
Definition
12-lead electrocardiogram, estimated glomerular filtration rate
Term
12-lead Electrocardiogram: definition and purpose
Definition
Electric test to detect left ventricular hypertrophy
Term
Target Organ Damage
Definition
Brain: Stroke, Eyes: Retinopathy, Heart:LVH/remodeling/failure, Kidney: Chronic Kidney Dz, PAD
Term
Treatment Goals: Moat Patients
Definition
Reduce HTN morbidity/mortality
BP under 140/90
Term
Treatment goals: Patients, with kidney dysfunction, heart condition, vessel dz, etc.
Definition
BP under 130/80
Term
Treatment Goals: Patients with left ventricular dysfunction
Definition
BP well under 120/80
Term
Stage 1 HTN therapy, no compelling indications
Definition
Thiazide diuretic
ACEI, ARB, CCB, or combo
Term
Stage 2 HTN therapy, no compelling indications
Definition
Two drug combination
thiazide diuretic + (ACEI/ARB/CCB)
Term
HTN therapy, Left Ventricular Dysfunction
Definition
Standard: Diuretic + ACEI, then add BB
Add-on: ARB or aldosterone antagonist
Term
HTN therapy, post- myocardial infarction
Definition
Standard: BB, then add ACEI/ARB
Add-on: aldosterone antagonist
Term
HTN therapy, Coronary Disease
Definition
Standard: BB then add ACEI/ARB
Add-on: CCB and diuretic
Term
HTN therapy, diabetes mellitus
Definition
Standard: ACEI/ARB
Add-on: Diuretic
Compound: BB
Term
HTN Treatment, Chronic Kidney Disease
Definition
Standard: ACEI or ARB
Term
HTN Therapy, Recurrent Stroke Prevention
Definition
Standard: Diuretic with ACEI or ARB
Term
Thiazides
Definition
Chlorthalidone, HCTZ, Indapamide, Metolazone
Term
Loop Diuretic
Definition
Bumetanide, Furosemide, Torsemide
Term
Potassium Sparing Diuretic
Definition
Amiloride, Triamterine, both plus HCTZ
Term
Aldosterone Antagonists
Definition
Eplerenone, Spironolactone
Dose in AM/afternoon
Term
ACEI
Definition
Anything ending in -pril
May cause dry cough, hyperkalemia. starting dose reduced for elderly/diuretic/volume depleted
Term
ARBs
Definition
Anything ending in -artan
Reduced dose in pts on diuretic/volume deplete/elderly, may cause hyperkalemia
Term
CCBs
Definition
Anything ending in -ipine
Diltiazem, Verapamil
ER preferred, block slow channels, reduce HR
Term
B-Blockers, cardioselective
Definition
Atenolol, Betaxolol, Bisoprolol, Metoprolol
Rebound HTN, benefit atrial tachycardia, may exacerbate asthma
Term
B-Blockers, nonselective
Definition
Nadolol, propranolol, timolol
Rebound HTN, exacerbate asthma, benefit tremor/migraine patients
Term
Mixed a/B blockers
Definition
Carvedilol, Labetalol
More orthostatic hypotension
Rebound HTN
Term
Treatment for African-Americans
Definition
Combination therapy
Thiazide + ACEI/ARB/CCB
More prone to cough/angioedema
Term
HTN Urgency medications
Definition
Captopril, clonidine, labetalol
Term
Hypertension Emergency
Definition
IV: sodium nitroprusside, nicardipine, fenoldopam, nitroglycerin, labetalol, esmolol.
Term
Pregnancy.
Definition
Preferred agents: Methyldopa common, labetalol also
Term
Pre-Eclampsia
Definition
BP> 140/90 after 20 weeks gestation and new onset proteinuria
Term
Eclampsia
Definition
onset of convulsions
Term
Gestational HTN
Definition
new onset HTN with no proteinuria
Term
Chronic HTN
Definition
HTN prior to pregnancy
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