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Hypertension Renin-Angiotensin Aldosterone System Inhibitors
Hypertension Renin-Angiotensin Aldosterone System Inhibitors
37
Pharmacology
Professional
09/09/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
How to ACEI work?
Definition
ACE = angiotensin converting enzyme inhibitors
Term
How to ARBs work?
Definition
ARB = angiotensin receptor blocker
Term
How does Aliskiren work?
Definition
Aliskrien = direct renin inhibitor and prevents conversion of angiotensinogen to AT1
Term

ACEIs, ARBs, and Aliskiren. Which decrase vasoconstriction, decrease aldosterone rlease, and have benefit in renal protection and heart failure?

Definition
All three of them
Term

Some patients are now receiving both ACEI and ARB together as apart of their therapy. What is the side effect of concern in doing this?

Definition

Both incrase potassium levels. And so potassium requires careful monitoring.

 

Term
What is the normal level of potassium?
Definition
3.5 - 5.5 mEq/L
Term
When ae ARBs given are they considered first- line?
Definition

They are considered first line but ARBs are given if patient is intolerant to ACEIs (dry cough) in practice

Term
What reaction must be watched out for in Blacks concerning ACEIs and ARBs?
Definition
Angioedema
Term

Angioedema more likely to occur with ACEIs or ARBs, or is the likelihood equivalent?

Definition

Angioedema is more likely with ACEIs than ARBs.

 

If a person had angioedema with either class of agents, all others are contraindicated since angioedema can quickly be FATAL.

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Term

Which of the ACEIs has more side effects relative to other in the same class and is not considered an optimal agent due to frequent dosing (BID or TID).

Definition

Captopril

 

Note: the others have Q daily or BID dosing

Term
Brand name for Valsartan
Definition
Diovan
Term
Brand name for Losartan
Definition
Cozaar
Term
Brand name for Irbesartan
Definition
Avapro
Term
Brand name for Candesartan
Definition
Atacand
Term
Brand name for Olmesartan
Definition
Benicar
Term
Brand name for Telmisartan
Definition
Micardis
Term
Brand name for Eprosartan
Definition

Teveten

 

Term
Pregnancy cateogory of ARBs
Definition
Pregnancy Category D
Term
What are the side effects of ARBs
Definition

Hyperkalemia and possible angioedema

 

 

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Term
[image]
Definition

Statement. Not a question.

 

Term
Brand name for Benazepril
Definition
Lotensin
Term
Brand name for Captropril
Definition
Capoten
Term
Brand name for Enalapril, Enalaprilat Injection
Definition
Vasotec
Term
Brand name for Fosinopril
Definition
Monopril
Term
Brand name for Lisonopril
Definition
Prinivil, Zestril
Term
Brand name for Quinepril
Definition
Accupril
Term
Brand name for Ramipril
Definition
Mavik
Term
Pregnancy category of ACEIs
Definition

First Trimester: Category C

Second & Third Trimester: Category D

Term
Do not use ACEIs in bilateral _____ ____ stenosis
Definition
renal artery, renal funtion will worsen
Term
Which of the ACEIs has the most side effects?
Definition
Captopril
Term
Which ACEIs can cause cough
Definition
All can cause cough
Term
How does ACEIs affect potassium?
Definition
Hyperkalemia
Term

ACEIs (and ARBs) are contraindicated when what happens?

 

Definition
If angioedema occurs or has occured in past treatment
Term
[image]
Definition
Statement. Not a question.
Term
Brand name for Aliskiren
Definition
Tekturna
Term
[image]
Definition
Statment. Not a question.
Term
How does Aliskiren affect furosemide levels?
Definition

decreases the level of furosemide

 

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