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Hypertension Calcium Channel Blockers
Hypertension Calcium Channel Blockers
21
Pharmacology
Professional
09/10/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
What are the two types of CCBs?
Definition

Dihydropyridines & Non-dihydropyridines

 

Term
How to know which are dihydropyridine CCBs?
Definition
they end in "pine"
Term
What ate the dihydrophyridine CCBs primarily used for?
Definition
HTN and angina
Term
What are the non-dihydropyridines used primarily for?
Definition

(Diltiazem and verapamil) are used primarily for arrhythmias to control/slow HR.

Term
The non-dihydropyridines (verpamil and diltiazem) have what affects on the heart?
Definition

negative inotropes (decrease contraction force) and negative chronotropes (decreased heart rate). The dihydropyridines do not have these properties.

Term
Whcih have significant drug interactions?
Definition

NON-Dihydropyridines

 

Diltiazem and verapamil are CYP 3A4 inhibitors and can have significant drug interactions (can increase other drugs), and they are also 3A4 substrates.

 

Dihydropyridines do not have significant drug interactions

Term
Which CCBs causes the most constipations?
Definition

non-dihydropyridines. Verapamil is the worst

Term
Name another side effect of CCBs
Definition
gingival hyperplasia
Term
Which of the CCBs cause peripheral vasodilation?
Definition

Dihydropyridines cause peripheral vasodilation, which can lead to reflex tachycrdia, headache, flushing, and peripheral edema

 

Amlodipine is used commonly since it dose not commonly cause these problems

Term
Which of the CCBs have capsular shells that can be seen in feces?
Definition

Covera HS

Adalat CC

Sular

Term
Clevidipine is contraindicated in what kind of allergies?
Definition
soy or egg
Term

With CCBs, you need to be careful to check the orange book since there is such a varitety of long - acting formulations - choose a generic that is AB -rated to the brand

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Definition
Statment. Not a question.
Term
Brand name for Amlodipine?
Definition
Norvasc
Term
Brand name for felodipine ER
Definition
Plendill
Term
Brand name for Nifedipine ER
Definition
Adalat CC, Procardia XL
Term
Brand name for Nifedipine IR?
Definition
Procardia
Term
[image]
Definition
Statement. Not a question.
Term
Name the non-dihydropyridines
Definition
Diltiazem & Verapimil
Term
[image]
Definition
Statement. Not a question.
Term
Name an acute care CCB
Definition
Clevidipine
Term
[image]
Definition
Statement. Not a question.
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