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Hypersensitivity
Types and descriptions
7
Nursing
Professional
10/28/2012

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Term
Type I Hypersensitivity
Definition
Rapid HS; acute inflammatory rxn; increase production of IgE; ex) allergic asthma, anaphylaxis, hay fever, allergic rhinits, latex/peanut/iodine/bee venom
Term
Type II Hypersensitivity
Definition
Cytotoxic; Body makes autoantibodies
Hemolytic anemias, thrombocytopenia purpura, hemolytic transfusion reactions
Term
Type III Hypersensitivity
Definition
Immune Complex; Antigens cause immune complex to form in the blood
Lodge in small vessels (kidney, skin, joints,)
Triggers inflammatory response
Ex Rheumoid arthritis, SLE, Serum Sickness
Symptoms: rash, lymphadenopathy, malaise, polyarthritis and nephritis
Self limiting
Term
Type IV Hypersensitivity
Definition
Delayed Hypersensitivity; Reactive cell in the T lymphocyte
Response is delayed
Local lymphocyte and macrophages and macrophages causing edema, induration, ischemia and tissue damage at the site
Example: positive PPD
Term
Type V Hypersensitivity
Definition
Stimulatory; Stimulation of normal cell surface receptor by autoantibody resulting in continuous “turned on” state
Example Graves disease

Autoimmune disorders
Sjogrens Syndrome
Goodpasture Syndrome
Term
Treatment for Type I
Definition
Avoidance, Antihistamines, Corticosteroids, Leukotriene antagonists, Nasal spray beclomethasone, EpiPen
Term
RCIDS
Definition
I-Rapid
II-Cytotoxic
III-Immune Complex
IV-Delayed
V-Stimulatory
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