Term
| Immediate Hypersensitivity (Type 1) |
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Definition
| IgE, vasoactive amines from mast cells, inflammatory cells. Vascular dilation, edema, smooth muscle contraction, mucus production, tissue injury, inflammation. |
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Term
| Antibody-Mediated HS (Type 2) |
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Definition
| IgG, IgM. Phagocytosis, lysis by complement or Fc receptors. C' dependent rxns, ADCC, Ab-mediated cellular dysfunction. |
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Term
| Immune Complex mediated (type 3) |
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Definition
| Ag-Ab-C' complex. Inflammation, necrotizing vasculitis (fibrinoid necrosis). |
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Term
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Definition
Activated T lymphs--> cytokines, mphs
--> T cell mediated cytotoxicity
Perivascular cellular infiltrates, edema, granuloma formation, cell destruction |
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Term
| Type 1 vasodilation- increased vasc perm |
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Definition
Histamine, PAF, LTs C/D/E, PGD
Neutral proteases (C' and kinins) |
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Term
| Type 1 smooth muscle contraction |
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Definition
| Histamine, LTs C/D/E, PAF, PGs. |
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Term
| Type 1 cellular infiltration |
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Definition
| Cytokines, LTB4, ECF/NCF (chemotactic factors) |
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Term
| Autoimmune Hemolytic Anemia |
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Definition
Type 2.
Ag= red cell membrane proteins. Opsonize, phagocytose RBCs. Hemolysis, anemia |
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Term
| Autoimmune Throbocytopenic Purpura (ITP) |
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Definition
Type 2. platelet membrane proteins (GpIIb-GpIIIa integrin).
Opsonize/phago platelets. Bleeding, spontaneous ecchymosis, petechial hemorrhage. |
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Term
| Pemphigus Vulgaris (bullous pemphigoid) |
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Definition
Type 2. Proteins in intercellular junction of epidermal cells (epidermal cadherin).
Ab-mediated activation of proteases, disrupt cellular adhesion. Skin vesicles (bullae). |
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Term
| Vasculitis caused by ANCA (Autoimm Nphil Cytoblastic AutoAb) |
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Definition
Type 2. Nphil granule proteins.
Nphil degranulation and inflamm.
Vasculitis. |
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Term
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Definition
Type 2. Noncollagenous protein in BM of kidney glomeruli and lung alveoli.
C' and Fc receptor mediated inflammation.
Nephritis, Lung hemorrhage. |
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Term
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Definition
Type 2. Streptococcal cell wall Ag. Ab cross-reacts with myocardial Ag.
Inflammation, mphg activation.
Myocarditis, arthritis |
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Term
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Definition
Type 2. Acetylcholine receptor.
Ab inhibits Ach binding, down-modulates receptors.
Muscle weakness, paralysis. |
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Term
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Definition
| Type 2. Ab stimulates TSH receptor. Hyperthyroidism. |
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Term
| Insulin-Resistant Diabetes (Type 2 DM) |
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Definition
| Type 2. Ab against insulin receptor, inhibit binding of insulin. Hyperglycemia, ketoacidosis. |
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Term
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Definition
Type 2. Target Ag is intrinsic factor of parietal cells. Neutralize intrinsic factor, decrease absorption of vit B12.
Abnormal erythropoiesis, anemia. |
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Term
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Definition
| Type 2. complement mediated. |
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Term
| Systemic Lupus Erythrematosus |
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Definition
| Type 3-systemic. DR3. Nuclear Ags. Nephritis, skin lesions, arthritis, etc. |
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Term
| Poststreptococcal Glomerulonephritis |
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Definition
| Type 3-systemic. Streptococcal wall Ags, may be planted in glomerular BM. Nephritis. |
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Term
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Definition
| Type 3. Hepatitis B virus Ags in some cases. Systemic vasculitis. |
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Term
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Definition
| Type 3. Bacterial antigens (ex Yersinia). Acute arthritis |
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Term
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Definition
Type 3-systemic. Various proteins ex foreign serum protein (horse anti-thymocyte).
Arthritis, vasculitis, nephritis. |
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Term
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Definition
| Type 3-local. various foreign proteins. Cutaneous vasculitis leading to necrosis. |
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Term
| Type 1 DM (insulin dependent) |
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Definition
Type 4. T cells attack pancreatic islet B cells (insulin, glutamic acid decarboxylase).
Insulitis (chronic inflamm in islets), destruction of B cells, diabetes. |
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Term
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Definition
| Type 4. T cell attack CNS myelin (myelin basic protein, proteolipid protein), Demyelination in CNS with perivascular inflammation; paralysis, ocular lesions. |
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Term
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Definition
| Type 4. unknown Ag in joint synovium. possible role of Abs. Chronic arthritis with inflammation, destruction of articular cartilage and bone |
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Term
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Definition
| Type 4. unkown Ag, role for commensal bacteria. Chronic intestinal inflammation, obstruction. |
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Term
| Peripheral neuropathy, Guillain-Barre syndrome |
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Definition
| Type 4. protein Ags of peripheral nerve myelin. Neuritis, paralysis. |
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Term
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Definition
| Type 4. environmental Ags (poison ivy, nickel allergy). Skin inflammation with blisters. |
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Term
| Hashimoto thyroiditis, GVHD, PPD Tb test |
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Definition
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