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Human Physiology Lecture Exam 1
CH 1,3,4,5
58
Physiology
Undergraduate 3
02/14/2012

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Term
What is Physiology?
Definition
the function of anatomical structures
Term
Homeostasis
Definition
state of reasonably stable balance between physiological variables
Term
What is the smallest particle, molecule, or substance that is considered to be alive?
Definition
a cell
Term
4 major cell type groups in humans?
Definition
1- muscle
2- nerve
3- epithelium
4- connective
Term
Intracellular fluid is?
Definition
fluid within cells (approx. 67% of fluid in body)
Term
Extracellular fluid is?
Definition
fluid that is found outside of the cell (1/3 of fluid found in body)
Term
Extracellular fluid - plasma = ?
Definition
interstitial fluid
Term
What do homeostatic control systems regulate?
Definition
cells, tissues and organs. a change in the tissues causes a reaction that will "correct" the change
Term
Equilibrium
Definition
staying at constant level without any extra energy added or taken away
Term
Steady state
Definition
constantly adding or taking away (cells use glucose, having to replace them)
Term
Set point
Definition
the level at steady state or at equilibrium there's a normal set point, but at times can change
Term
This feedback system is not common in physiology. It reinforces the change; if high, it gets higher and lower gets lower and lower
Definition
Positive Feedback system
Term
This feedback system is an icrease or decrease in a variable that causes the opposite response (if high, gets low...etc)
Definition
Negative Feedback
Term
Set points
Definition
can be reset. (some examples are: oxygen levels, glucose levels, temperature-fever)
Term
Feed forward regulation
Definition
ex: nerve cells detect change in temperature
-when smell a delicious meal and start to salivate
-fight or flight response
Term
Reflexes
Definition
specific involuntary, unpremeditated, unlearned "built-in" response to a particular stimulus
Term
Reflex arc
Definition
pathway that mediates a reflex
Term
Effectors
Definition
this can be any cell, but muscles and glands are most common
Term
4 types of Intercellular Chemical Messengers
Definition
1- hormones
2 - neurotransmitter
3- paracrine agent
4- autocrine agent
Term
hormones
Definition
chemical released into bloodstream
Term
paracrine agent
Definition
affecting cells right next to it
Term
Adaptation
Definition
due to genetics, happens to an organism over a period of time through evolution (ex: ability to shiver, homeostatic control system)
Term
Acclimization
Definition
improved functioning of an already existing homeostatic system, normally reversible (ex. at beginning of summer you are very warm, at end of summer your body is used to the heat)
Term
Negative Balance w/in body
Definition
loss exceeds gain, so total amount in the body is decreasing
Term
Positive Balance w/in body
Definition
gain exceeds loss, so the total amount in the body is increasing
Term
Homeostasis wants the gain to = the loss, also called...
Definition
Stable Balance
Term
Cell membrane
Definition
regulates what goes in/out of cell. made up of phospholipid bilayer
Term
amphipathic
Definition
anything with polar & nonpolar region
Term
Outer layer of phospholipid bilayer
Definition
hydrophilic "water-loving" heads
Term
Inner layer of phospholipid bilayer
Definition
hydrophobic "water-fearing" tails
Term
Bilayer has fluid movement which makes it a....?
And what other three things does the cell membranes phospholipid bilayer contain?
Definition
Fluid Mosaic Model.

-cholestrol (for movement)
-proteins
-Glycocalyx sugars; how the cell is differentiated
Term
Integral Membrane Protein of cell membrane
Definition
amphipathic.
transmembrane proteins: have things going through them and in them, embedded in cell and can move around within cell
Term
Peripheral Proteins of cell membrane
Definition
polar molecules, on INSIDE of cell, not embedded within nonpolar.
*can interact with transmembrane proteins
Term
Desmosome (membrane cellular junction)
Definition
found in heart, space between cells

contain CADHERINS--protein branches that connect the cells
Term
Tight junctions (membrane cellular junction)
Definition
where plasma membrane meet together, nothing can flow through this space.
Term
Gap junction (membrae cellular junction)
Definition
used for cell communication, ions travel through connecting channels between membrane walls. found in heart
Term
Genes
Definition
pieces of DNA that code for proteins
Term
Genome
Definition
total genetic info in DNA of a cell
Term
Chromosome
Definition
DNA and histones
Term
2-step process of DNA to proteins....
Definition
Transcription, translation
Term
Transcription
Definition
copying of gene, making DNA into RNA
Term
Translation
Definition
process of RNA into proteins
Term
Genetic Mutation
Definition
alteration in nucleotide sequence, mutagens cause genetic mutation

*not always bad--evolution; new adaptations!
Term
Ligand
Definition
binds with protein
Term
For protein and ligand to bond....
Definition
they must be very close to eachother, specificity, when ligand binds to protein it CHANGES FUNCTION of protein!
Term
high affinity binding site

-intermediate affinity binding site
-low affinity binding site
Definition
negatively charged ligand, positively charged protein
Term
Saturation
Definition
percentage of occupied binding sites, concentration of unbound ligands

*to speed up how many proteins bind to ligands, can keep adding more ligands, but will have to stop at 100% saturation
Term
Higher affinity in lower saturation could mean they're all....
Definition
binding
Term
competition
Definition
more than 1 ligand can bind to a site. effects of ligand A may be reduced or diminished by presence of ligand B or C
Term
modulation ligands
Definition
binding to proteins can change the shape of proteins. when you alter the shape of a second binding site, you change the characteristics of that site
Term
Allosteric modulation
Definition
uses modulary molecule to change shape of protein

-charged molecules can change the shape of proteins
phosphate group - phosphorylation
Term
Covalent modulation
Definition
requires energy, uses phosphate group to change molecular charge and change shape of protein
Term
Enzymes are involved in metabolism which is the process of...
Definition
building up and breaking down of organic molecules
Term
Anabolism
Definition
synthesis of organic molecules
Term
Catabolism
Definition
breakdown of organic molecules
Term
Lock and Key enzyme process
Definition
fit together perfect, enzyme-substrate complex
Term
Induced Fit enzyme process
Definition
cause enzyme to fit around them
Term
4 things that affect the rate of chemical reactions
Definition
1- activation energy
2- substrate concentrations
--can increase up to saturation
3- enzyme concentrations
--level off when enzymes all binded
4- enzyme activity
--affinity
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