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HUCM Tricarboxylic Acid Cycle
Broom is killin the competition
27
Medical
Graduate
08/09/2011

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Term
What membrane of mitochondria has Porin - channel forming protein permeable to molecules up to 10,000 daltons
Definition
Outer Membrane
Term
What mitochondrial membrane has Protein complexes of the electron transport chain and oxidative phosphorylation, succinate dehydrogenase, transport proteins
Definition
Inner Membrane (cristae)
Term
What mitochondrial compartment has : Enzymes of TCA cycle except succinate dH, enzymes of urea cycle and fatty acid oxidation, mitochondrial DNA, RNA, enzymes for transcription and protein synthesis
Definition
Mitochondrial Matrix
Term
What is the cofactor for Pyruvate dehydrogenase (decarboxylation)
Definition
TPP
Term
What are the two cofactors for Dihydrolipoyl transacetylase?
Definition
Lipoamide and CoA
Term
What are the two cofactors of Dihydrolipoyl dehydrogenase?
Definition
FAD and NAD+
Term
The five enzymes of the mitochondrial matrix are: Pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase, ? ? ?, and ? ? ?.
Definition
regulatory protein kinase and regulatory protein phosphatase
Term
One part of the TCA cycle is the oxidation of acetyl CoA, production of ? and reduced co-enzymes (NADH, FADH2)
Definition
GTP
Term
The TCA cycle provides ? for biosynthetic pathways.
Definition
intermediates
Term
Another function of TCA cycle is to produce energy through oxidation of NADH, FADH2 by the ? ? ?.
Definition
Electron Transport Chain
Term
TCA cycle is a catabolic energy producing pathway that requires
Definition
oxygen
Term
Tissue specificity high in ?, heart, kidney cortex, liver
Definition
brain
Term
The subcellular location of TCA cycle is mostly in the ? ? except succinate dehydrogenase which is located in the ? ? ?
Definition
mitochondrial matrix
mitochondrial inner membrane
Term
Inner mitochondrial membrane is impermeable to ?, acetyl CoA, Oxaloacetate.
Definition
NADH
Term
End product of TCA cycle is ? ?
Definition
intramitochondrial NADH
Term
? allosterically inhibits isocitrateDH, KetoGluDH
Definition
ATP
Term
? allosterically stimulates isocitrate dehydrogenase
Definition
ADP
Term
? allosterically stimulates isocitrate dehydrogenase
Definition
ADP
Term
The TCA cycle is ? by a high intramitochondrial NAD+/NADH ratio
Definition
STIMULATED
Term
NADH and FADH2 must be re-oxidized by ? ? ? in order to regenerate NAD+ and FAD so that flow through the cycle will continue.
Definition
Electron Transport Chain
Term
The electron transport chain (etc) and cycle only function when ADP, Pi, ? are available.
Definition
O2
Term
Pyruvate dehydrogenase (PDH) is inactivated by phosphorylation of ?
Definition
Serine
Term
ATP, NADH, Acetyl CoA inhibit PDH by promoting PHOSPHORYLATION of
Definition
PDH
Term
Ca++ and Insulin stimulate PDH by promoting
Definition
DEphosphorylation
Term
Inner mitochondrial membrane is impermeable to ?
Definition
oxaloacetate
Term
The end products (NADH, Acetyl CoA, ATP) of the PDH reaction promote the inactivation of PDH via a ?-? ? ?
Definition
non-cAMP regulatory kinase
Term
Ca++ and Insulin promote activation of PDH via the ? ?;this is important in directing excess CHO towards the synthesis of ? ? ?.
Definition
regulatory phosphatase
fat via citrate
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